Vitamin K is a fat-soluble vitamin discovered as an essential factor for blood coagulation. It is suggested that vitamin K can benefit several aging-related diseases, including osteoporosis, osteoarthritis, and dementia. We previously reported the cross-sectional association of vitamin K insufficiency with frailty in community-dwelling older adults.
Materials and methods
In October 2020, a health examination of community-dwelling older adults (The Otassha Study) was performed, including frailty evaluation and blood tests. We used a ucOC and OC ratio (ucOC/OC) to indicate vitamin K insufficiency. One year later, we conducted a follow-up evaluation of frailty on 518 people who were not frail at baseline. The serum ucOC/OC at the baseline examination was divided into quartiles (Q1, Q2, Q3, and Q4). Odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariate binary logistic regression for each quartile of ucOC/OC to determine the risk of incident frailty in the follow-up study, with the lowest quartile (Q1) as the reference.
Among the 518 older adults who were not frail at baseline, 66 people (12.7%) became frail in the follow-up study. In the multivariate binary logistic regression analysis, setting the lowest quartile of ucOC/OC (Q1) as a reference, the OR of the incident frailty in the highest quartile (Q4) was 2.53 (95% CI 1.07, 4.92) which was significantly different from Q1.
The findings of this longitudinal study suggest that vitamin K insufficiency has nutritional importance in predicting the future incidence of frailty in the Japanese older adult population.
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We thank all the participants for The Otassha Study.
This study was funded by TMIG institutional project funding (SASM).
Conflict of interest
All the authors have no conflicts of interest.
This study complied with the current laws regarding ethical standards in Japan and the study protocol was approved by the institutional ethical committee of the Tokyo Metropolitan Institute for Geriatrics and Gerontology (approved number: H18-17, R1-20).
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Azuma, K., Osuka, Y., Kojima, N. et al. Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: The Otassha Study. J Bone Miner Metab 41, 817–821 (2023). https://doi.org/10.1007/s00774-023-01457-4