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Is Helicobacter pylori infection associated with osteoporosis? a systematic review and meta-analysis

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Abstract

Introduction

This study used systematic review and meta-analysis to evaluate the association between Helicobacter pylori infection and osteoporosis.

Materials and methods

PubMed, Ovid and Web of Science were searched to include observational studies published in English comparing bone mineral density changes between Helicobacter pylori-positive and -negative participants. The quality of the included literature was assessed using the Newcastle–Ottawa Quality Assessment Scale (NOS). R software was used for meta-analysis, and odds ratio (OR) and 95% confidence interval (CI) were calculated to evaluate the relationship between Helicobacter pylori infection and osteoporosis.

Results

Twenty-two studies involving 24,176 participants were included in the study. Our meta-analysis showed that Helicobacter pylori infection was significantly associated with the risk of osteoporosis (OR: 1.12, 95%CI: 1.03, 1.22). Participants infected with the CagA-positive Helicobacter pylori strain were more likely to develop osteoporosis (OR = 1.42, 95%CI: 1.09; 1.85).

Conclusion

Infection with Helicobacter pylori, particularly the CagA-positive strain, has been associated with an increased risk of osteoporosis. The bone health of Helicobacter pylori-positive patients deserves more attention.

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Data availability

Data to support the findings of this study are available on request from the corresponding authors.

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Funding

This work was supported by the National Natural Science Foundation of China (81873998).

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Author notes

  1. Chuang Xiong and Runhan Zhao have contributed equally to this work.

Authors and Affiliations

  1. Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing, 400016, People’s Republic of China

    Chuang Xiong, Runhan Zhao, Jingtao Xu, Hao Liang, Jun Zhang, Yanran Huang & Xiaoji Luo

  2. Orthopedic Laboratory of Chongqing Medical University, Chongqing, People’s Republic of China

    Xiaoji Luo

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  1. Chuang Xiong
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  2. Runhan Zhao
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  5. Jun Zhang
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Contributions

Study design: CX, XL; Data collection: CX, RZ, Data statistical analysis: CX, RZ, HL, JZ, JX, YH; Data analysis and interpretation: CX, XL, RZ, HL, JZ, JX, YH; Manuscript drafting: CX; Review and revise manuscripts: XL. XL is the guarantor of full responsibility for the entire work, including the study design, data access, and the decision to submit and publish the manuscript. All authors have approved the submitted manuscript.

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Correspondence to Xiaoji Luo.

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Xiong, C., Zhao, R., Xu, J. et al. Is Helicobacter pylori infection associated with osteoporosis? a systematic review and meta-analysis. J Bone Miner Metab 41, 74–87 (2023). https://doi.org/10.1007/s00774-022-01379-7

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  • DOI: https://doi.org/10.1007/s00774-022-01379-7

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