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Cortical thickness mapping at segmented regions in the distal radius using HR-pQCT

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

An advanced method of analyzing the cortical bone microarchitecture of the distal radius using high-resolution peripheral quantitative computed tomography (HR-pQCT) was developed.

Materials and methods

The subjects were 60 women (20: aged 30–49, 20: aged 50–69, and 20: aged 70–89 years). The distal radius was scanned by HR-pQCT, and its cortical volumetric bone mineral density (Ct.vBMD), cortical porosity (Ct.Po), and cortical thickness (Ct.Th) were measured. The cortical bone was also divided into three areas according to whether its thickness was < 0.5 mm, 0.5–1.0 mm, or > 1.0 mm, and the percentage of each surface area in the total surface area of cortical bone was calculated (Ct.Th (<0.5), Ct.Th (0.5–1.0), Ct.Th (>1.0), respectively). The cortical bone at the distal radius was further segmented into dorsal, palmar, radial, and ulnar sides, and the above-described parameters were measured in these regions.

Results

Integral analysis showed that Ct.vBMD and Ct.Th decreased and Ct.Po increased with age (R = − 0.62, − 0.55, and 0.54). Ct.Th (< 0.5) expanded with age (R = 0.49), with the rate of change between those aged 30–49 years and those aged 50–69 years being 106.7%. On regional analysis, the expansion of Ct.Th (< 0.5) with age was particularly marked on the dorsal and palmar side (R = 0.51 and 0.49), where the rate of change between those aged 30–49 years and those aged 50–69 years was the highest, at 196.1 and 149.6%.

Conclusion

The method to identify areas of cortical bone thinning in the segmented regions of the dorsal, palmar, radial, and ulnar sides of the distal radius using HR-pQCT may offer a sensitive assessment of age-related deterioration of cortical bone.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Shingo Ota, Ko Chiba, Narihiro Okazaki, Akihiko Yonekura, Masato Tomita & Makoto Osaki

Authors
  1. Shingo Ota
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  2. Ko Chiba
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  3. Narihiro Okazaki
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  4. Akihiko Yonekura
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  5. Masato Tomita
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  6. Makoto Osaki
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Contributions

Study design: KC; data acquisition: SO and NO; data analysis: SO and KC; data management: SO; statistical analysis: SO; data interpretation: SO, KC, AY, MT, and MO; drafting of the manuscript: SO and KC; revision of the manuscript content: KC and MO; approval of the final version of the manuscript: SO, KC, NO, AY, MT, and MO.

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Correspondence to Ko Chiba.

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Nagasaki University Hospital Clinical Research Ethics Committee (registration numbers: 15083105).

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Ota, S., Chiba, K., Okazaki, N. et al. Cortical thickness mapping at segmented regions in the distal radius using HR-pQCT. J Bone Miner Metab 40, 1021–1032 (2022). https://doi.org/10.1007/s00774-022-01370-2

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  • DOI: https://doi.org/10.1007/s00774-022-01370-2

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