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Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005–2015

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

This study aimed to clarify the trends in the prevalence of osteoporosis among general inhabitants using population-based cohort data of the baseline and the survey 10 years later.

Materials and Methods

The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted in 2005–2007; 1690 participants (596 men, 1094 women, mean age 65.2 years) completed all examinations of osteoporosis, including a questionnaire of medical information in the present/past and bone mineral density measurement using dual-energy absorptiometry. The fourth survey was performed in 2015–2016; 1906 individuals (637 men, 1269 women, 65.0 years) completed assessments identical to those at the baseline survey. Osteoporosis was defined using the World Health Organization criteria.

Results

The prevalence of lumbar spine (L2–L4) osteoporosis at the baseline survey was 13.6% (men, 3.4%; women, 19.2%) and that at the fourth survey was 9.7% (men, 1.4%; women, 13.9%), which decreased significantly (p < 0.01), while that of the femoral neck was not significantly different between the baseline and fourth surveys. Regarding the prevalence of osteoporosis of L2–L4 or the femoral neck, the prevalence of osteoporosis in women aged ≥ 70 was 38.8% at the fourth survey and 48.9% at the baseline study; thus, the prevalence at the fourth survey was significantly lower than that at the baseline survey (p < 0.01).

Conclusions

In the population-based survey with a 10-year interval, the prevalence of osteoporosis at lumbar spine tended to decrease significantly. This preferable change in osteoporosis could contribute to the decrease in the occurrence of osteoporotic fracture in the future.

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Acknowledgements

The authors wish to thank Dr Naoki Hirabayashi of Kawakami Clinic, Hidakagawa Town; Mrs Tomoko Takijiri, Mrs Rie Takiguchi, Mrs Kyoko Maeda, Ms Ikuyo Ueyama, Mrs Michiko Mori, Mrs Hisayo Sugimoto, and other members of the public office in Hidakagawa Town; and Mrs Tamako Tsutsumi, Mrs Kanami Maeda, Mrs Megumi Takino, Mrs Shuko Okada, Mrs Kazuyo Setoh, Mrs Chise Ryouno, Mrs Miki Shimosaki, Mrs Chika Yamaguchi, Mrs Yuki Shimoji, and other members of the public office in Taiji Town for their assistance in locating and scheduling the participants for examinations. We would also like to thank Mrs Kyoko Hattori, Mrs Toki Sakurai, Mrs Saeko Sahara, and Mr Noriyuki Oe for their assistance with data reduction and administration.

Funding

This work was supported by a Grant-in-Aid funding from the Ministry of Health, Labour and Welfare: H17-Men-eki-009 (Director, Kozo Nakamura), H20-Choujyu-009 (Director, Noriko Yoshimura), H23-Choujyu-002 (Director, Toru Akune), H25-Choujyu-007 (Director, Noriko Yoshimura), H25-Nanchitou (Men)-005 (Director, Sakae Tanaka), 19FA1401 (Director, Sakae Tanaka), 19FA1007, 20JA1001 (Director, Hiroyuki Oka), 19FA1017 (Director, Etsuo Chosa), 19FB1001 (Director, Yutaka Osuga), 21FA1006 (Director, Hiroshi Yamada), and 22FA1009 (Director, Sakae Tanaka). The study was also supported by Scientific Research grants B19H03895, B26293139, B23390172, and B20390182, and Challenging Exploratory Research grants 21K19631, 18K18447, 15K15219, and 24659317 to Noriko Yoshimura; Scientific Research grants B26293331, B23390356, and C20591774 and Challenging Exploratory Research grants 26670307 and 23659580 to Shigeyuki Muraki; Challenging Exploratory Research grants 24659666 and 21659349 and Young Scientists A18689031 to Hiroyuki Oka; Scientific Research grants B26293329, B23390357, and C20591737 and Challenging Exploratory Research grant 25670293 to Toru Akune; Scientific Research grant S50282661 to Sakae Tanaka; Scientific Research grant B18H03164 to Yosuke Yamada; Challenging Exploratory Research grant C18K09122 to Harumoto Yamada; and by Collaborating Research with NSF from the Ministry of Education, Culture, Sports, Science and Technology in Japan 08033011–00262 (Director, Noriko Yoshimura). The study was partly supported by grants from the Japan Agency for Medical Research and Development (17dk0110028h0001, Director, Noriko Yoshimura; 17gk0210007h0003, 19gk0210018h0002, and 22gk0210034h0001, Director, Sakae Tanaka; 22dk0110047h0001, Director, Kanae Mure). Further, the study was partly supported by grants from the Japan Osteoporosis Society (Noriko Yoshimura, Chiaki Horii, Shigeyuki Muraki, Hiroyuki Oka, and Toru Akune) and Japan Osteoporosis Foundation (2015, Noriko Yoshimura) and research aids from the Japanese Orthopaedic Association (JOA-Subsidized Science Project Research 2006-1 and 2010-2, Director, Hiroshi Kawaguchi; and 2014-1, Director, Kozo Nakamura), the Japanese Society for Musculoskeletal Medicine (2015, Director, Shigeyuki Muraki; and 2017, Director, Noriko Yoshimura), Mitsui Sumitomo Insurance Welfare Foundation (2016, Director, Noriko Yoshimura), and Japan Dairy Association (2017, Director, Noriko Yoshimura).

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Authors and Affiliations

  1. Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan

    Noriko Yoshimura, Toshiko Iidaka & Shigeyuki Muraki

  2. Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan

    Chiaki Horii & Sakae Tanaka

  3. Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan

    Hiroyuki Oka

  4. Tokyo Neurological Center, Tokyo, 105-0001, Japan

    Hiroshi Kawaguchi

  5. Towa Hospital, Tokyo, 120-0003, Japan

    Kozo Nakamura

  6. National Rehabilitation Center for Persons with Disabilities, Saitama, 359-0042, Japan

    Toru Akune

Authors
  1. Noriko Yoshimura
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  2. Toshiko Iidaka
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  3. Chiaki Horii
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  4. Shigeyuki Muraki
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  5. Hiroyuki Oka
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  6. Hiroshi Kawaguchi
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  7. Kozo Nakamura
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  8. Toru Akune
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  9. Sakae Tanaka
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Contributions

NY made substantial contributions to the study concept, design, and protocol, data collection and screening, statistical analyses, data interpretation, and drafting of the paper or revising it critically for important intellectual content. TS and CH made substantial contributions to the study design and protocol, data collection and screening, and revising the draft critically for important intellectual content. SM and HO made substantial contributions to the study design and protocol, data collection and screening, statistical analyses, and data interpretation. HK, KZ, TA, and ST made substantial contributions to the study concept, design, and protocol, data interpretation, drafting of the paper or revising it critically for important intellectual content. All authors had full access to all study data and had final responsibility in the decision to submit for publication.

Corresponding author

Correspondence to Noriko Yoshimura.

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Conflict of interest

All authors have no conflicts of interest.

Ethics approval

The study was conducted with the approval of the ethics committees of the University of Tokyo (No. 1264 and No. 1326) and the University of Wakayama Medical University (No. 373).

Consent to participate

All participants provided written informed consent.

Consent for publication

All participants gave informed consent for publication of the results of the ROAD study, without any personal information.

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Yoshimura, N., Iidaka, T., Horii, C. et al. Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005–2015. J Bone Miner Metab 40, 829–838 (2022). https://doi.org/10.1007/s00774-022-01352-4

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  • DOI: https://doi.org/10.1007/s00774-022-01352-4

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