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Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Little is known about whether substances inducing tissue protein degeneration in the oral cavity are associated with the number of teeth present in postmenopausal women. We sought to investigate the association of urinary pentosidine and serum homocysteine levels with the number of teeth and subsequent tooth loss in Japanese postmenopausal women.

Materials and methods

Among participants in the Nagano Cohort Study, 785 postmenopausal women (mean age, 68.1 years) participated in the present study. The number of teeth was re-counted at the time of follow-up in 610 women. Poisson regression analysis was used to investigate differences in the number of teeth among quartiles of pentosidine or homocysteine, adjusting for covariates that correlated with the number of teeth. A Cox proportional hazard model was used to evaluate the association of subsequent tooth loss with pentosidine or homocysteine levels.

Results

Pentosidine quartiles were not associated with the number of teeth at baseline. Participants in the highest homocysteine quartile had significantly fewer teeth at baseline than those in the third and lowest quartiles (p < 0.001 for both). Those in the second quartile had fewer teeth than those in the third (p = 0.001) and lowest (p < 0.001) quartiles. An increased risk of tooth loss during follow-up was significantly associated with higher urinary pentosidine (hazard ratio = 1.073 for 10 pmol/mgCre; p = 0.001).

Conclusion

Postmenopausal women with higher homocysteine levels had fewer teeth at baseline. A higher pentosidine concentration increased the risk of subsequent tooth loss. High pentosidine or homocysteine concentrations may be associated with tooth loss in postmenopausal women.

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Acknowledgements

The Nagano Cohort Study was funded by the Budget of Research Institute and Practice for Involutional Diseases, Japan. We thank Analisa Avila, MPH, ELS, of Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri, Nagano, 399-0781, Japan

    Akira Taguchi

  2. Department of Orthopaedic Surgery, Jikei University School of Medicine, 3-19-18 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8471, Japan

    Mitsuru Saito

  3. Department of Internal Medicine, Research Institute and Practice for Involutional Diseases, 1610-1 Meisei, Misato, Azumino, Nagano, 399-8101, Japan

    Masataka Shiraki

  4. Department of Hard Tissue Research, Graduate School of Oral Medicine, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri, Nagano, 399-0781, Japan

    Akira Taguchi

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Contributions

Conception and design: AT, MS, and MS. Analysis and interpretation of the data: AT and MS. Drafting of the article: AT, MS, and MS. Critical revision of the article for important intellectual content: MS and MS. Final approval of the article: all the authors.

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Correspondence to Akira Taguchi.

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Conflict of interest

A Taguchi, M Saito, and M Shiraki declare that they have no conflicts of interest.

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All the procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol of this investigation was approved by the ethics committee of the Research Institute and Practice for Involutional Diseases, Japan.

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Informed consent was obtained from all the individual participants included in the study.

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Taguchi, A., Saito, M. & Shiraki, M. Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women. J Bone Miner Metab 40, 773–781 (2022). https://doi.org/10.1007/s00774-022-01343-5

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  • DOI: https://doi.org/10.1007/s00774-022-01343-5

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