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Positive association of fasting plasma glucose with bone mineral density in non-diabetic elderly females

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Abstract

Introduction

Previous studies involving diabetics have shown different associations between fasting plasma glucose (FPG) and bone mineral density (BMD). The different effects of FPG on BMD are due to varying effects of antidiabetic drugs, glycemic control and diabetic complications in the diabetic patients. It is necessary to identify the association in subjects without diabetes.

Materials and methods

A total of 2367 females over 65 were included in this cross-sectional study. Subjects were grouped by FPG quartile. BMD and the prevalence of osteoporosis were compared among different FPG quartiles. Multiple logistic regression was used to analyze the independent contribution of FPG to osteoporosis.

Results

Subjects in lower FPG quartile had lower BMD (P < 0.05). Subjects with osteoporosis had a lower FPG than the subjects of osteopenia, and both were lower than subjects with normal bone mass (P < 0.001 for all). Compared with the lowest FPG quartile, subjects in the 3rd and the 4th quartiles have a lower risk of osteoporosis in the lumbar spine (OR 0.77, 95% CI 0.59–0.98; OR 0.76, 95% CI 0.56–0.99, respectively), the total hip (OR 0.72, 95% CI 0.56–0.96; OR 0.75, 95% CI 0.53–0.99, respectively), and the femoral neck (OR 0.73, 95% CI 0.50–0.97; OR 0.71, 95% CI 0.54–0.92, respectively) after adjustment for age, BMI, education, physical activity and menopausal age.

Conclusion

FPG was positively associated with BMD in non-diabetic elderly females. Low FPG may increase the risk of osteoporosis in the non-diabetic elderly females in China.

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Acknowledgements

The study was supported by the Doctor Start-up Fund of Nantong University (135420617022), and the Science and Technology Project from Nantong University (13180083).

Funding

The study was supported by the Doctor Start-up Fund of Nantong University, 135420617022, Yi-Hua Lu, Science and Technology Project from Nantong University, 13180083, Yi-Hua Lu

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Authors and Affiliations

  1. Department of Epidemiology and Health Statistics, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, People’s Republic of China

    Yi-Hua Lu

  2. Department of Cardio Thoracic, Nantong University Affiliated Nantong Rich Hospital, Nantong, Jiangsu, 226010, People’s Republic of China

    Liang Gu & Yun Jiang

Authors
  1. Yi-Hua Lu
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  2. Liang Gu
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  3. Yun Jiang
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Contributions

YHL: substantial contributions to design, data analysis and drafting the article. LG: acquisition and interpretation of data. YJ: conception, and revising critically for important intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yun Jiang.

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Conflict of interest:

All authors have no conflicts of interest.

Ethics approval and consent to participate

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Each participant signed an informed consent document before entering the study.

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Lu, YH., Gu, L. & Jiang, Y. Positive association of fasting plasma glucose with bone mineral density in non-diabetic elderly females. J Bone Miner Metab 40, 755–762 (2022). https://doi.org/10.1007/s00774-022-01341-7

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  • DOI: https://doi.org/10.1007/s00774-022-01341-7

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