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Emerging role of m6A modification in osteogenesis of stem cells

  • Review Article
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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

The differentiation of stem cells into osteoblasts is a key link in the treatment of bone defects and other orthopedic diseases. N6-methyladenosine (m6A) modification, an important post-transcriptional modification, is a methylation that occurs at the N6 site of RNA adenylate. The modification plays a regulatory role in the growth and development of biological individuals, the directional differentiation of stem cells and the occurrence of diseases. It is involved in various processes of the fate decision of stem cells. And it regulates the development and constant renewal of bone and keeps bone homeostasis by controlling and maintaining the balance between osteogenesis and adipogenesis. Meanwhile, it also affects the progress of orthopedic-associated diseases such as degenerative osteoporosis and bone tumor. In this review, we mainly summarize the new findings of three key molecules including Writers, Erasers and Readers which regulate m6A modification, and the emerging role of m6A modification in determining the fate and directed differentiation potential of stem cells, especially highlight the regulatory mechanism of osteogenic differentiation, the balance between osteogenesis and adipogenesis and the occurrence and development of bone-related diseases. It may provide some important ideas about finding new strategies to recover from bone defect and degenerative bone disease.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (No. 51935014, 81871498, 82072084, 81871494, 81572577), Jiangxi Provincial Natural Science Foundation of China (20192ACB20005), Innovation for graduate students of Central South University2020 (2020zzts774, 2020zzts223), The Hunan Provincial Innovation Foundation For Postgraduate (CX20210318), Innovation for graduate students of Central South University2021 (2021zzts0915).

Funding

This study was supported by the National Natural Science Foundation of China (No. 51935014, 81871498, 82072084, 81871494, 81572577), Jiangxi Provincial Natural Science Foundation of China (20192ACB20005), Innovation for graduate students of Central South University2020 (2020zzts774, 2020zzts223), the Hunan Provincial Innovation Foundation For Postgraduate (CX20210318), Innovation for graduate students of Central South University2021 (2021zzts0915).

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Authors and Affiliations

  1. NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China

    Zi Zou, Tiantian He, Ying Liu, Leliang Zheng, Yancheng Zhong, Yuqing Mo & Shuping Peng

  2. The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, Hunan, China

    Zi Zou, Tiantian He, Ying Liu, Leliang Zheng, Yancheng Zhong, Yuqing Mo & Shuping Peng

  3. Hunan Key Laboratory of Non Resolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China

    Zi Zou, Tiantian He, Ying Liu, Leliang Zheng, Yancheng Zhong, Yuqing Mo & Shuping Peng

  4. Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang, 330013, China

    Cijun Shuai

  5. State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, 410083, China

    Cijun Shuai

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  1. Zi Zou
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  2. Tiantian He
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  3. Ying Liu
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  4. Leliang Zheng
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  5. Yancheng Zhong
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  6. Yuqing Mo
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  7. Shuping Peng
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  8. Cijun Shuai
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Contributions

The idea for the article: SP and CS; drafted the work: ZZ; revised the work: TH and YL; literature search: LZ and YZ; data analysis: YM.

Corresponding authors

Correspondence to Shuping Peng or Cijun Shuai.

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Zou, Z., He, T., Liu, Y. et al. Emerging role of m6A modification in osteogenesis of stem cells. J Bone Miner Metab 40, 177–188 (2022). https://doi.org/10.1007/s00774-021-01297-0

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