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Family caregiver burden of patients with osteoporotic fracture in Japan

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Osteoporotic fractures are the most common serious consequence of osteoporosis. Patients who suffer such fractures often require caregiver assistance afterwards. This study characterized the humanistic burden experienced by family caregivers of patients with osteoporotic fractures in Japan.

Materials and methods

Family caregivers were defined as individuals who provided non-professional care to an osteoporotic fracture patient (> 50 years old). Caregivers were asked through an online survey panel about their caregiving situation, health-related quality of life (HRQoL), work impairment, and the health status of their patient. The Zarit Caregiver Burden Interview (ZBI-22), 8-item Short Form Health Survey (SF-8), and Work Productivity and Activity Impairment Caregiver version (WPAI-CG) were used to better understand the impact of osteoporotic fracture caregiving.

Results

Respondents (n = 309) were family caregivers who were employed (81.6%) and cared for a parent (71.5%). Over 75% of caregivers had HRQoL physical and mental component scores below 50 on SF-8. Although most patients received welfare services (78.3%), the mean ZBI-22 score was 42.2 and 57.0% of caregivers perceived their burden to be moderate or severe (ZBI-22 score ≥ 41). Over half of caregivers changed their employment status due to their caregiving responsibilities and experienced 61.4% overall work impairment. The mean productivity loss for caregivers was estimated to be over 43,000 JPY per week.

Conclusion

The substantial humanistic and financial burden of caregiving by family members to osteoporotic fracture patients should be considered when evaluating the impact of fragility fractures, disease management and support systems for osteoporosis.

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Acknowledgements

We would like to thank Hyojin Kim and William Y. H. Kuan of Syneos Health for their contributions in the conduct, analysis, and editorial assistance on this study. This study was sponsored by Amgen K. K. and Astellas Pharma Inc.

Author information

Authors and Affiliations

  1. Soen Orthopaedics, Osteoporosis and Rheumatology Clinic, Kobe, Japan

    Satoshi Soen

  2. Amgen K.K., Tokyo, Japan

    Koyo Usuba & Kenji Adachi

  3. Syneos Health, Tokyo, Japan

    Bruce Crawford

Authors
  1. Satoshi Soen
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  2. Koyo Usuba
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  3. Bruce Crawford
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  4. Kenji Adachi
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Contributions

All authors participated in conceptualizing and designing the study. BC conducted the survey and the analysis and drafted the manuscript. SS, KU and KA provided clinical expertise, and advised on survey design. All authors reviewed and provided revisions to the manuscript and approved the final version for publication.

Corresponding author

Correspondence to Satoshi Soen.

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Conflict of interest

S.S. has received consulting fees, speaking fees, and/or honoraria from Asahi Kasei Pharma, Astellas, Amgen, Daiichi-Sankyo, Eli Lilly Japan, UCB Japan. BC is an employee at Syneos Health. Syneos Health received funding from Amgen K.K. to conduct the data collection, data analysis and manuscript development. KA is an employee of Amgen and owns Amgen stock. KU was an employee of Amgen at the time of the study.

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Supplementary Information

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Supplementary figure 1 (TIF 42 KB) Distribution of ZBI-22 scores by site of fracture(s)

Supplementary figure 2 (TIF 69 KB) SF-8 scores by site of fracture(s). (a) Mean SF-8 in PCS (b) Mean SF-8 in MCS

774_2020_1197_MOESM3_ESM.tif

Supplementary figure 3 (TIF 86 KB) Percentage of caregivers below 50 in each SF-8 domain and summary score by site of fracture(s)

Supplementary figure 4 (TIF 56 KB) Overall work impairment by the site of fracture(s)

Supplementary figure 5 (TIF 53 KB) ZBI-22 scores by LTC insurance level

Supplementary figure 6 (TIF 41 KB) Distribution of ZBI-22 scores by LTC insurance level

Supplementary figure 7 (TIF 72 KB) SF-8 scores by LTC insurance level. (a) Mean SF-8 in PCS (b) Mean SF-8 in MCS

774_2020_1197_MOESM8_ESM.tif

Supplementary figure 8 (TIF 92 KB) Percentage of caregivers below 50 in each SF-8 domain and summary score by LTC insurance level

Supplementary figure 9 (TIF 51 KB) Overall work impairment by LTC insurance level

Supplementary table 1 (DOCX 13 KB) Utilization of care services

Supplementary table 2 (DOCX 13 KB) Productivity impairment of caregivers

774_2020_1197_MOESM12_ESM.docx

Supplementary table 3 (DOCX 20 KB) Caregiver’s perceived burden, work productivity loss per week, HRQoL and perception of caregiving, stratified by site of fracture

774_2020_1197_MOESM13_ESM.docx

Supplementary table 4 (DOCX 20 KB) Caregiver’s perceived burden, work productivity loss per week, HRQoL and perception of caregiving, stratified by LTC insurance level

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Soen, S., Usuba, K., Crawford, B. et al. Family caregiver burden of patients with osteoporotic fracture in Japan. J Bone Miner Metab 39, 612–622 (2021). https://doi.org/10.1007/s00774-020-01197-9

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  • DOI: https://doi.org/10.1007/s00774-020-01197-9

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