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Evaluation of aortic calcification using a three-dimensional volume-rendering method in patients with end-stage kidney disease

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Very few studies have been performed to evaluate both the severity and site of aortic calcification (AC) in both end-stage kidney disease (ESKD) and diabetes mellitus (DM). The purpose of our study was to examine the utility of a newly developed three-dimensional (3D) visualization and quantification method compared with other methods to evaluate vascular calcification in ESKD patients with and without DM.

Materials and methods

Fifty patients with ESKD before initiating hemodialysis at our hospital were included in the present study. They were divided into the two groups, depending on the presence or absence of DM: Control group (n = 31) and DM group (n = 19). The volume and site of AC were evaluated via computed tomography (CT) scan using a 3D visualization and quantification method.

Results

Total calcification volume was significantly greater in the DM group than in the Control group. Calcification volume in the descending and abdominal aortas was greater in the DM group compared to the Control group. There were no significant differences in calcification volume in the aortic root, ascending aorta, and aortic arch. Calcification volume of the whole aorta, the descending aorta, and the abdominal aorta were each significantly correlated with age, diastolic blood pressure and pulse pressure.

Conclusion

This study using a 3D visualization and quantification method demonstrated that AC was more severe and occurred more frequently in the abdominal aorta in ESKD patients with DM compared to those without DM. This method would enable us to precisely evaluate the volume and distribution of AC.

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Funding

This study was partly supported by grants from Bayer Yakuhin Co. and Kidney Foundation (Japan, JKFB11-30). The funders had no roles in study design, data collection, data analysis, data interpretation, or preparation of this manuscript.

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Authors and Affiliations

  1. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Hideki Fujii, Keiji Kono, Kentaro Watanabe, Shunsuke Goto & Shinichi Nishi

  2. Division of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

    Tatsuya Nishii & Atsushi Kono

Authors
  1. Hideki Fujii
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  2. Keiji Kono
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  3. Kentaro Watanabe
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  4. Shunsuke Goto
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  5. Tatsuya Nishii
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  6. Atsushi Kono
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  7. Shinichi Nishi
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Correspondence to Hideki Fujii.

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Fujii, H., Kono, K., Watanabe, K. et al. Evaluation of aortic calcification using a three-dimensional volume-rendering method in patients with end-stage kidney disease. J Bone Miner Metab 39, 439–445 (2021). https://doi.org/10.1007/s00774-020-01172-4

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  • DOI: https://doi.org/10.1007/s00774-020-01172-4

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