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Papillary thyroid carcinoma is a risk factor for severe osteoporosis

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Thyroid-stimulating hormone (TSH)-suppressive therapy is recommended after surgical treatment in high-risk papillary thyroid carcinoma (PTC) patients. TSH-suppressive therapy is a known risk factor for osteoporosis and fractures. However, whether patients with PTC themselves are at a higher risk of osteoporosis than healthy individuals remains unclear. This study aimed to clarify whether PTC is a risk factor for osteoporosis.

Materials and methods

Serum and urinary biochemical parameters, bone mineral density (BMD), and presence of vertebral fractures (VFs) and non-VFs were evaluated in 35 PTC patients and 35 age- and sex-matched healthy individuals. We compared the parameters between PTC and control subjects and performed multiple logistic regression analyses after adjustments for variables.

Results

Patients with PTC had higher body mass index (BMI) and hemoglobin (Hb)A1c, as well as lower eGFR and intact PTH than controls (p < 0.05, each). There were no significant differences in the prevalence of osteoporosis and VFs and non-VFs between patients with PTC and controls. However, the prevalence of severe osteoporosis diagnosed according to WHO criteria was significantly higher in PTC subjects (34.3%) than in controls (11.4%, p < 0.05). Multivariate logistic regression analyses adjusted for age, BMI, eGFR and HbA1c identified PTC as being associated with the presence of severe osteoporosis (odds ratio, 4.20; 95% confidence interval, 1.05–16.8; p < 0.05).

Conclusions

We identified PTC as a risk factor for severe osteoporosis, independent of BMI, renal function and glucose profile.

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Acknowledgements

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Authors and Affiliations

  1. Department of Internal Medicine 1, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan

    Masakazu Notsu, Mika Yamauchi, Miwa Morita & Toshitsugu Sugimoto

  2. Health and Nutrition, The University of Shimane, Matsue, Shimane, Japan

    Kiyoko Nawata

Authors
  1. Masakazu Notsu
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  2. Mika Yamauchi
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  3. Miwa Morita
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  4. Kiyoko Nawata
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  5. Toshitsugu Sugimoto
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Contributions

MN was responsible for designing and conducting the study. MN and KN performed the data collection. MN and MM and analyzed the data. MY and TS contributed equipment/materials. MN and MY wrote the paper. All authors approved the final version.

Corresponding author

Correspondence to Masakazu Notsu.

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Conflict of interest

Masakazu Notsu, Mika Yamauchi, Miwa Morita, Kiyoko Nawata a nd Toshitsugu Sugimoto declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Cite this article

Notsu, M., Yamauchi, M., Morita, M. et al. Papillary thyroid carcinoma is a risk factor for severe osteoporosis. J Bone Miner Metab 38, 264–270 (2020). https://doi.org/10.1007/s00774-019-01053-5

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  • DOI: https://doi.org/10.1007/s00774-019-01053-5

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