Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women


Populations of East Asian countries have been known to have low calcium intakes and low serum 25(OH)D concentrations, suggesting that Ca and vitamin D (VitD)-deficiencies are commonly observed. These nutritional imbalances may lead to low peak bone mass (PBM). The low PBM seen in Ca/VitD-deficient individuals may lead to osteoporosis, as well as an increased risk of fracture. A survey was conducted in young Japanese women (n = 296, 21.2 ± 2.3 years old) on their Ca/VitD intakes and serum 25(OH)D levels, which demonstrated a significant positive correlation between VitD intake and serum 25(OH)D levels (R 2 = 0.020, P = 0.016), and the proportion with serum 25(OH)D over 20 ng/mL was significantly increased with VitD intake (P = 0.013). Serum 25(OH)D was negatively correlated to serum intact parathyroid hormone (R 2 = 0.053, P < 0.001). On receiver operating characteristic curve analysis, the VitD intake threshold for maintaining 25(OH)D levels at 20 ng/mL or higher was 11.6 μg/day or greater. It was suggested that the recommended VitD intake allowance, defined in the Adequate Intakes as 5.5 μg/day, may not be sufficient to maintain serum 25(OH)D levels for bone health.

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The authors would like to express their sincere acknowledgement to the people who voluntarily participated in the present study. This study was financially supported by a grant from the Japan Osteoporosis Foundation.

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Correspondence to Hiroaki Ohta.

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Conflict of interest

H.O. received lecture fees from Pfizer. M.S. received consulting fees from Asahi Kasei Pharma and Teijin Pharma. T.K. is an employee of Asahi Kasei Corporation. N.T., Y.O., and T.O. have no conflicts of interest.

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Ohta, H., Kuroda, T., Tsugawa, N. et al. Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women. J Bone Miner Metab 36, 620–625 (2018). https://doi.org/10.1007/s00774-017-0879-7

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  • Vitamin D intake
  • 25-Hydroxyvitamin D
  • Insufficiency
  • Young Japanese women