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The protective effect of lycopene intake on bone loss in ovariectomized rats

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Abstract

Antioxidant lycopene supplementation has been shown to decrease oxidative stress and have beneficial effects on bone health. However, it remains unclear whether lycopene exerts its beneficial effect on bone metabolism through mitigation of oxidative stress in vivo. The aim of this study was to investigate whether lycopene intake protects against bone loss by reducing oxidative stress in ovariectomized rats. Female Sprague–Dawley 6-week-old rats were ovariectomized and randomly divided into four groups according to the lycopene content of their diet: 0, 50, 100, and 200 ppm. The tibial bone mineral density (BMD) in the 50, 100, and 200 ppm groups was significantly higher than that in the 0 ppm group. Serum and urinary bone resorption marker levels were significantly lower in the 50, 100, and 200 ppm groups than in the 0 ppm group. There was no significant difference in systemic oxidative stress markers among all groups. However, systemic oxidative stress levels were inversely correlated with the tibial BMD. Our findings suggest that lycopene intake significantly inhibits bone loss by suppressing bone resorption in ovariectomized rats. Further studies are necessary to clarify the effect of lycopene on oxidative stress in local tissues such as bone tissue.

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Acknowledgments

The authors would like to thank Kyoritsu Bussan Co., Ltd., Japan, for supplying the lycopene samples.

Conflict of interest

All authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan

    Yuki Iimura, Umon Agata, Satoko Takeda, Yuki Kobayashi & Naomi Omi

  2. Department of Life Science and Bioengineering, Graduate School of Life and Environmental Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8572, Japan

    Shigeki Yoshida

  3. Department of Food and Nutrition, School of Home-Economics, Japan Women’s University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo, 112-8681, Japan

    Ikuko Ezawa

  4. Health, Physical Education and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan

    Naomi Omi

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  1. Yuki Iimura
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  2. Umon Agata
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Correspondence to Naomi Omi.

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Iimura, Y., Agata, U., Takeda, S. et al. The protective effect of lycopene intake on bone loss in ovariectomized rats. J Bone Miner Metab 33, 270–278 (2015). https://doi.org/10.1007/s00774-014-0596-4

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  • DOI: https://doi.org/10.1007/s00774-014-0596-4

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