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Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover

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Abstract

Control of phosphate is important in the management of chronic kidney disease with mineral and bone disorder (CKD-MBD), for which lanthanum carbonate, a non-calcium phosphate-binding agent, has recently been introduced; however, it remains to be determined whether it has any beneficial or deleterious effect on bone remodeling. In the present study, the effects of lanthanum carbonate were examined in an animal model that mimics low turnover bone disease in CKD, i.e., thyroparathyroidectomized (TPTX) and 5/6 nephrectomized (NX) rats undergoing a constant infusion of parathyroid hormone (PTH) and thyroxine injections (TPTX-PTH-5/6NX). Bone histomorphometry at the second lumbar vertebra and tibial metaphysis revealed that both bone formation and resorption were markedly suppressed in the TPTX-PTH-5/6NX model compared with the sham-operated control group, and treatment with lanthanum carbonate was associated with the stimulation of bone formation but not an acceleration of bone resorption. Lanthanum treatment caused a robust stimulation of bone formation with an activation of osteoblasts on the endosteal surface of femoral diaphysis, leading to an increase in cortical bone volume. Thus, lanthanum carbonate has the potential to stimulate bone formation in cases of CKD-MBD with suppressed bone turnover.

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Acknowledgments

We thank members of our Department (NCGG) for discussion and Mr. Tsuyoshi Makino, Hisashi Uchiyama and Yasuhide Kanada, and Ms. Hatsumi Ikuma (Japan SLC Inc., Shizuoka, Japan) for the surgical procedures. Pacific Edit reviewed the manuscript before submission.

Conflict of interest

This study was carried out with a research Grant from Bayer Yakuhin Ltd (Osaka, Japan).

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Authors and Affiliations

  1. Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi, 474-8511, Japan

    Toshio Fumoto & Kyoji Ikeda

  2. Medical Work-Life-Balance Center, Nagasaki University Hospital, Nagasaki, 852-8501, Japan

    Masako Ito

Authors
  1. Toshio Fumoto
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  2. Masako Ito
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  3. Kyoji Ikeda
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Correspondence to Kyoji Ikeda.

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Fumoto, T., Ito, M. & Ikeda, K. Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover. J Bone Miner Metab 32, 484–493 (2014). https://doi.org/10.1007/s00774-013-0521-2

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  • DOI: https://doi.org/10.1007/s00774-013-0521-2

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