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Serum sclerostin levels in healthy men over 50 years of age

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Abstract

The aim of this study is to evaluate the relationship of serum sclerostin levels with age, cystatin C, bone mineral density (BMD) and biochemical markers of bone turnover in healthy Hungarian men >50 years of age. We determined serum levels of sclerostin and examined its relationship to age, cystatin C, osteocalcin, C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, 25-hydroxyvitamin D, parathyroid hormone, and L1–L4 (LS) and femur neck (FN) BMD data available from 194 randomly selected ambulatory men belonging to the HunMen cohort. In the study population as a whole [n = 194; age (median, range) 59 (51–81) years], statistically significant correlation was found between sclerostin and age (r = 0.211; p = 0.003), cystatin C (r = 0.246; p = 0.001), FN BMD (r = 0.147; p = 0.041) and LS BMD (r = 0.169; p = 0.019). Compared to middle-aged men (age ≤59 years, n = 98), elderly men (age >59 years, n = 96) had significantly higher serum sclerostin levels (67.8 ± 15.9 vs 63.5 ± 14 pmol/L; p = 0.047). Among men with normal (T score >−1.0) FN BMD, the elderly had significantly higher serum sclerostin levels compared to the middle-aged men (70.4 ± 17 vs 63.9 ± 11.5 pmol/L; p = 0.019). Furthermore, among the elderly men cystatin C was the only significant predictor of serum sclerostin levels (standardized regression coefficient (β) = 0.487; p < 0.001). In the studied healthy elderly cohort, this study reports a significant increase in sclerostin levels with increasing age and deteriorating kidney function as determined by plasma cystatin C levels.

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Acknowledgments

This work is supported by the OTKA 105073 Research Grant (HPB) and the TÁMOP 4.2.1./B-09/1/KONV-2010-0007 Project (HPB, JW, EK, RF, AB, PAS), which is implemented through the New Hungary Development Plan, co-financed by the European Social Fund.

Conflict of interest

All authors state that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Medical and Health Science Center, University of Debrecen, Nagyerdei Krt. 98, 4032, Debrecen, Hungary

    Harjit Pal Bhattoa, John Wamwaki, Edit Kalina, Roza Foldesi & Peter Antal-Szalmas

  2. Regional Osteoporosis Center, Department of Obstetrics and Gynecology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

    Harjit Pal Bhattoa & Adam Balogh

Authors
  1. Harjit Pal Bhattoa
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  2. John Wamwaki
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  3. Edit Kalina
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  4. Roza Foldesi
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  6. Peter Antal-Szalmas
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Correspondence to Harjit Pal Bhattoa.

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Bhattoa, H.P., Wamwaki, J., Kalina, E. et al. Serum sclerostin levels in healthy men over 50 years of age. J Bone Miner Metab 31, 579–584 (2013). https://doi.org/10.1007/s00774-013-0451-z

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  • DOI: https://doi.org/10.1007/s00774-013-0451-z

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