Journal of Bone and Mineral Metabolism

, Volume 31, Issue 2, pp 144–152 | Cite as

Dissimilarity of femur aging in men and women from a Nationwide Survey in Korea (KNHANES IV)

  • Kyoung Min Kim
  • Jung Soo Lim
  • Kwang Joon Kim
  • Han Seok Choi
  • Yumie Rhee
  • Han Jin Oh
  • Hoon Choi
  • Woong Hwan Choi
  • Jung Gu Kim
  • Sung-Kil LimEmail author
Original article


In light of the differences in hip fracture rates between men and women of different ages, age-related changes in bone structure that lead to bone fragility might differ depending on both age and gender. To investigate age-related bone loss and geometric deterioration of the femur, hip scans of 1,504 men and 2,076 women aged 19–92 years acquired during the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV) using dual-energy X-ray absorptiometry (DXA) were analyzed with a structural analysis program. Cross-sectional area and cortical thickness with bone mineral density in men started to decline from the third decade and continued to decline at a constant rate. However, in women, these parameters remained nearly constant until the fifth decade and then declined at a more rapid rate than that seen in men. Consequently, changes in the buckling ratio, earlier onset, and continuation of increase over the lifetime were observed in men. A relatively later onset with a greater acceleration with aging was observed in women. Taken together, there were obvious gender and age differences in structural trends with age. Bone aging, i.e., bone loss and geometric deterioration, actually begins at a young age, especially in men, and osteoporosis prevention strategies should target not only the elderly but also younger individuals.


Aging Bone mineral density Fracture Osteoporosis 



This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MEST) (No. 20110001024). We also express our heartfelt thanks to the Korean Osteoporosis Society.

Conflict of interest

The authors disclose that they have no conflicting interests in this work.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan 2012

Authors and Affiliations

  • Kyoung Min Kim
    • 1
  • Jung Soo Lim
    • 1
  • Kwang Joon Kim
    • 1
  • Han Seok Choi
    • 2
  • Yumie Rhee
    • 1
  • Han Jin Oh
    • 3
  • Hoon Choi
    • 4
  • Woong Hwan Choi
    • 5
  • Jung Gu Kim
    • 6
  • Sung-Kil Lim
    • 1
    Email author
  1. 1.Division of Endocrinology, Department of Internal Medicine, Institute of Endocrine ResearchYonsei University College of MedicineSeoulKorea
  2. 2.Division of Endocrinology and Metabolism, Department of Internal MedicineDongguk University Ilsan HospitalGoyangKorea
  3. 3.Department of Family Medicine, College of MedicineKwandong UniversityGangneungKorea
  4. 4.Department of Obstetrics and Gynecology, College of MedicineInje University Sanggye Paik HospitalSeoulKorea
  5. 5.Division of Endocrinology and Metabolism, Department of Internal MedicineHanyang University College of MedicineSeoulKorea
  6. 6.Department of Obstetrics and Gynecology, College of MedicineSeoul National UniversitySeoulKorea

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