Journal of Bone and Mineral Metabolism

, Volume 30, Issue 2, pp 125–135 | Cite as

Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial ‘human osteoclastology’

  • Shigeru Kotake
  • Toru Yago
  • Manabu Kawamoto
  • Yuki Nanke
Review Article


Many papers have reported that osteoclasts play an important role in the pathogenesis of rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the roles of osteoclasts were not highlighted in RA bone resorption. In recent years, the number of articles on the roles of osteoclasts and interleukin (IL)-17 in the pathogenesis of RA has increased exponentially. In this review article, we describe our articles on the roles of osteoclasts and IL-17 in joint destruction in RA, from 1990 to 2011, and highlight a novel term, ‘human osteoclastology’, which we have used since 2008.


Interleukin-17 (IL-17) Osteoclast Osteoclastology Th17 Rheumatoid arthritis 


Conflict of interest

All authors have no conflicts of interest.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2011

Authors and Affiliations

  • Shigeru Kotake
    • 1
  • Toru Yago
    • 1
  • Manabu Kawamoto
    • 1
  • Yuki Nanke
    • 1
  1. 1.Institute of RheumatologyTokyo Women’s Medical UniversityTokyoJapan

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