Skip to main content

Advertisement

SpringerLink
Log in

Urinary levels of cross-linked N-terminal telopeptide of type I collagen and nutritional status in Japanese professional baseball players

  • Original Article
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

The objective of the present study was to investigate the nutritional status from the aspect of bone metabolism in Japanese elite male athletes with increased bone resorption. Urinary levels of a bone resorption marker, cross-linked N-terminal telopeptide of type 1 collagen (NTX), were measured in 71 professional baseball players (age, 18–39 years); the mean urinary NTX level was 65.6 (range, 17.5–269.0) nM BCE/mM Cr. Of 71 athletes, 9 with high levels of urinary NTX (greater than mean + 1 SD) were examined by measuring serum biochemical markers and nutritional assessment (simple food frequency questionnaire). Serum biochemical marker analysis showed that 7 of these 9 athletes had vitamin D insufficiency, as indicated by low serum levels of 25-hydroxyvitamin D, and that all 9 athletes showed vitamin K insufficiency as indicated by low levels of vitamins K1 and K2. Nutritional assessment revealed high intakes of protein and low intakes of calcium and vitamin D based on adequate intake (AI). However, daily vitamin K intake achieved the AI. These results suggest that there exist elite male athletes who show increased bone resorption and calcium and vitamin D insufficiency. However, there was a discrepancy between vitamin K intake and serum levels of vitamins K1 and K2. The present study raised an issue regarding the nutritional status from the point of view of bone metabolism in elite male athletes such as professional baseball players.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sahota O (2000) Osteoporosis and the role of vitamin D and calcium-vitamin D deficiency, vitamin D insufficiency and vitamin D sufficiency. Age Ageing 29:301–304

    Article  CAS  PubMed  Google Scholar 

  2. Chapuy MC, Pamphile R, Paris E, Kempf C, Schlichting M, Arnaud S, Garnero P, Meunier PJ (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7:439–443

    Article  CAS  PubMed  Google Scholar 

  3. Jesudason D, Need AG, Horowitz M, O’Loughlin PD, Morris HA, Nordin BE (2002) Relationship between serum 25-hydroxyvitamin D and bone resorption markers in vitamin D insufficiency. Bone (NY) 31:626–630

    CAS  Google Scholar 

  4. Nakamura K (2006) Vitamin D insufficiency in Japanese populations: from the viewpoint of the prevention of osteoporosis. J Bone Miner Metab 24:1–6

    Article  CAS  PubMed  Google Scholar 

  5. Nakamura K, Nashimoto M, Matsuyama S, Yamamoto M (2001) Low serum concentrations of 25-hydroxyvitamin D in young adult Japanese women: a cross-sectional study. Nutrition 17:921–925

    Article  CAS  PubMed  Google Scholar 

  6. Willis KS, Peterson NJ, Larson-Meyer DE (2008) Should we be concerned about the vitamin D status of athletes? Int J Sport Nutr Exerc Metab 18:204–224

    CAS  PubMed  Google Scholar 

  7. Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K (2008) Calcium and vitamin D supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res 23:741–749

    Article  CAS  PubMed  Google Scholar 

  8. Okano T, Shimomura Y, Yamane M, Suhara Y, Kamao M, Sugiura M, Nakagawa K (2008) Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice. J Biol Chem 283:11270–11279

    Article  CAS  PubMed  Google Scholar 

  9. Suhara Y, Wada A, Okano T (2009) Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells. Bioorg Med Chem Lett 19:1054–1057

    Article  CAS  PubMed  Google Scholar 

  10. Hauschka PV, Lian JB, Cole DEC, Gundberg CM (1989) Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 69:990–1047

    CAS  PubMed  Google Scholar 

  11. Koshihara Y, Hoshi K (1997) Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. J Bone Miner Res 12:431–438

    Article  CAS  PubMed  Google Scholar 

  12. Shearer MJ (1995) Vitamin K. Lancet 345:229–234

    Article  CAS  PubMed  Google Scholar 

  13. Vermeer C, Jie KSG, Knapen MHJ (1995) Role of vitamin K in bone metabolism. Annu Rev Nutr 15:1–22

    Article  CAS  PubMed  Google Scholar 

  14. Tabb MM, Sun A, Zhou C, Grun F, Errandi J, Romero K, Pham H, Inoue S, Mallick S, Lin M, Forman BM, Blumberg B (2003) Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. J Biol Chem 278:43919–43927

    Article  CAS  PubMed  Google Scholar 

  15. Hara K, Akiyama Y, Nakamura T, Murota S, Morita I (1995) The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone (NY) 16:179–184

    CAS  Google Scholar 

  16. Iwamoto J, Takeda T, Sato Y (2004) Effects of vitamin K2 on osteoporosis. Curr Pharm Des 10:2557–2576

    Article  CAS  PubMed  Google Scholar 

  17. Iwamoto J, Takeda T, Sato Y (2006) Effects of vitamin K2 on the development of osteopenia in rats as the models of osteoporosis. Yonsei Med J 47:157–166

    Article  CAS  PubMed  Google Scholar 

  18. Kalkwarf HJ, Khoury JC, Bean J, Elliot JG (2004) Vitamin K, bone turnover, and bone mass in girls. Am J Clin Nutr 80:1075–1080

    CAS  PubMed  Google Scholar 

  19. Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PD (1997) Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82:719–724

    Article  CAS  PubMed  Google Scholar 

  20. Tsugawa N, Shiraki M, Suhara Y, Kamao M, Ozaki R, Tanaka K, Okano T (2008) Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab 26:79–85

    Article  CAS  PubMed  Google Scholar 

  21. Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T (2006) Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr 83:380–386

    CAS  PubMed  Google Scholar 

  22. Kuwabara A, Tanaka K, Tsugawa N, Nakase H, Tsuji H, Shide K, Kamao M, Chiba T, Inagaki N, Okano T, Kido S (2009) High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int 20:935–942

    Article  CAS  PubMed  Google Scholar 

  23. Uenishi K, Ishida H, Nakamura K (2008) Development of a simple food frequency questionnaire to estimate intakes of calcium and other nutrients for the prevention and management of osteoporosis. J Nutr Sci Vitaminol (Tokyo) 54:25–29

    Article  CAS  Google Scholar 

  24. Orimo H (ed) (2006) Japanese guidelines for the prevention and treatment of osteoporosis, 2006 edition. Life Sciences Publishing, Tokyo

  25. Sasaki S (2008) Dietary reference intakes (DRIs) in Japan. Asia Pac J Clin Nutr 17(Suppl 2):420–444

    PubMed  Google Scholar 

  26. Nishizawa Y, Nakamura T, Ohta H, Kushida K, Gorai I, Shiraki M, Fukunaga M, Hosoi T, Miki T, Chaki O, Ichimura S, Nakatsuka K, Miura M (2005) Committee on the Guidelines for the Use of Biochemical Markers of Bone Turnover in Osteoporosis of the Japan Osteoporosis Society: guidelines for the use of biochemical markers of bone turnover in osteoporosis (2004). J Bone Miner Metab 23:97–104

    Article  PubMed  Google Scholar 

  27. Karlsson KM, Karlsson C, Ahlborg HG, Valdimarsson O, Ljunghall S, Obrant KJ (2003) Bone turnover responses to changed physical activity. Calcif Tissue Int 72:675–680

    Article  CAS  PubMed  Google Scholar 

  28. Karlsson KM, Karlsson C, Ahlborg HG, Valdimarsson O, Ljunghall S (2003) The duration of exercise as a regulator of bone turnover. Calcif Tissue Int 73:350–355

    Article  CAS  PubMed  Google Scholar 

  29. Herrmann M, Herrmann W (2004) The assessment of bone metabolism in female elite endurance athletes by biochemical bone markers. Clin Chem Lab Med 42:1384–1389

    Article  CAS  PubMed  Google Scholar 

  30. Maimoun L, Mariano-Goulart D, Couret I, Manetta J, Peruchon E, Micallef JP, Verdier R, Rossi M, Leroux JL (2004) Effects of physical activities that induce moderate external loading on bone metabolism in male athletes. J Sports Sci 22:875–883

    Article  CAS  PubMed  Google Scholar 

  31. Martin RB (2007) Targeted bone remodeling involves BMU steering as well as activation. Bone (NY) 40:1574–1580

    CAS  Google Scholar 

  32. Heino TJ, Kurata K, Higaki H, Väänänen HK (2009) Evidence for the role of osteocytes in the initiation of targeted remodeling. Technol Health Care 17:49–56

    PubMed  Google Scholar 

  33. Frost HM (1994) Wolff’s law and bone’s structural adaptations to mechanical usage: an overview for clinicians. Angle Orthod 64:175–188

    CAS  PubMed  Google Scholar 

  34. Bolton-Smith C, McMurdo ME, Paterson CR, Mole PA, Harvey JM, Fenton ST, Prynne CJ, Mishra GD, Shearer MJ (2007) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res 22:509–519

    Article  CAS  PubMed  Google Scholar 

  35. Nattiv A, Loucks AB, Manore MM, Sanborn CF, Sundgot-Borgen J, Warren MP, American College of Sports Medicine (2007) American College of Sports Medicine position stand. The female athlete triad. Med Sci Sports Exerc 39:1867–1882

    Article  PubMed  Google Scholar 

  36. Manore MM, Kam LC, Loucks AB, International Association of Athletics Federations (2007) The female athlete triad: components, nutrition issues, and health consequences. J Sports Sci 25(Suppl 1):S61–S71

    Article  PubMed  Google Scholar 

Download references

Conflict of interest statement

We have no conflict of interest.

Author information

Authors and Affiliations

  1. Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Jun Iwamoto, Tsuyoshi Takeda & Hideo Matsumoto

  2. Laboratory of Physiological Nutrition, Kagawa Nutrition University, Saitama, Japan

    Kazuhiro Uenishi

  3. Laboratory of Administrative Dietetics, Kagawa Nutrition University, Saitama, Japan

    Hiromi Ishida

  4. Department of Neurology, Mitate Hospital, Fukuoka, Japan

    Yoshihiro Sato

Authors
  1. Jun Iwamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tsuyoshi Takeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazuhiro Uenishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hiromi Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshihiro Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hideo Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun Iwamoto.

About this article

Cite this article

Iwamoto, J., Takeda, T., Uenishi, K. et al. Urinary levels of cross-linked N-terminal telopeptide of type I collagen and nutritional status in Japanese professional baseball players. J Bone Miner Metab 28, 540–546 (2010). https://doi.org/10.1007/s00774-010-0158-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-010-0158-3

Keywords

Search

Navigation