Skip to main content

Advertisement

SpringerLink
Log in

Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man

  • Case Report
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

For 10 years, a young man was followed for a severe osteoporosis associated with a considerable reduction in height and a massive weight loss. The constant increase of signs of tissue impregnation with thyroid hormones and the molar ratios of α-TSH suggested an inappropriate secretion of thyrotropin. Magnetic resonance imaging finally revealed a thyrotropic microadenoma of the pituitary gland. This case gives some new additional information on thyrotropin-induced osteoporosis. To our knowledge such a case has never been reported in the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Zuniga S, Mendoza V, Espinoza IF, Zarate A, Mason M, Mercado M (1997) A plurihormonal TSH-secreting pituitary microadenoma: report of a case with an atypical clinical presentation and transient response to bromocriptine therapy. Endocr Pathol 8(1):81–86

    Article  PubMed  Google Scholar 

  2. Gurnell M, Rajanayagam O, Barbar I, Jones MK, Chatterjee VK (1998) Reversible pituitary enlargement in the syndrome of resistance to thyroid hormone. Thyroid 8(8):679–682

    Article  PubMed  CAS  Google Scholar 

  3. Sanno N, Teramoto A, Osamura RY (2001) Thyrotropin-secreting pituitary adenomas. Clinical and biological heterogeneity and current treatment. J Neurooncol 54(2):179–186

    Article  PubMed  CAS  Google Scholar 

  4. Bonneville JF (2000) Pituitary adenomas: value of MR imaging. J Radiol 81(9):939–942

    PubMed  CAS  Google Scholar 

  5. Wu YY, Chang HY, Lin JD, Chen KW, Huang YY, Jung SM (2003) Clinical characteristics of patients with thyrotropin-secreting pituitary adenoma. J Formos Med Assoc 102(3):164–171

    PubMed  Google Scholar 

  6. Beck-Peccoz P, Persani L, Mantovani S, Cortelazzi D, Asteria C (1996) Thyrotropin-secreting pituitary adenomas. Metabolism 45(8 suppl 1):75–79

    Article  PubMed  CAS  Google Scholar 

  7. Boni G, Ferdeghini M, Bellina CR, Matteucci F, Castro Lopez E, Parenti G, Canapicchi R, Bianchi R (1995) [111In-DTPA-D-Phe]-octreotide scintigraphy in functioning and non-functioning pituitary adenomas. Q J Nucl Med 39(4 Suppl 1):90–93

    PubMed  CAS  Google Scholar 

  8. Socin HV, Chanson P, Delemer B, Tabarin A, Rohmer V, Mockel J, Stevenaert A, Beckers A (2003) The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. Eur J Endocrinol 148(4):433–442

    Article  PubMed  CAS  Google Scholar 

  9. Sarlis NJ, Gourgiotis L, Koch CA, Skarulis MC, Brucker-Davis F, Doppman JL, Oldfield EH, Patronas NJ (2003) MR imaging features of thyrotropin-secreting pituitary adenomas at initial presentation. AJR Am J Roentgenol 181(2):577–582

    PubMed  Google Scholar 

  10. Pasquini E, Faustini-Fustini M, Sciarretta V, Saggese D, Roncaroli F, Serra D, Frank G (2003) Ectopic TSH-secreting pituitary adenoma of the vomerosphenoidal junction. Eur J Endocrinol 148(2):253–257

    Article  PubMed  CAS  Google Scholar 

  11. Lindboe CF, Unsgard G, Myhr G, Scott H (1993) ACTH and TSH producing ectopic suprasellar pituitary adenoma of the hypothalamic region: case report. Clin Neuropathol 12(3):138–141

    PubMed  CAS  Google Scholar 

  12. Katznelson L, Alexander JM, Klibanski A (1993) Clinical review 45: clinically nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 76(5):1089–1094

    Article  PubMed  CAS  Google Scholar 

  13. Akiyoshi F, Okamura K, Fujikawa M, Sato K, Yoshinari M, Mizokami T, Hattori K, Kuwayama A, Takahashi Y, Fujishima M (1996) Difficulty in differentiating thyrotropin secreting pituitary microadenoma from pituitary-selective thyroid hormone resistance accompanied by pituitary incidentaloma. Thyroid 6(6):619–625

    Article  PubMed  CAS  Google Scholar 

  14. Safer JD, Colan SD, Fraser LM, Wondisford FE (2001) A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma. Thyroid 11(3):281–291

    Article  PubMed  CAS  Google Scholar 

  15. Vlaeminck-Guillem V, Wemeau JL (1999) Thyroid hormone resistance syndromes: clinical aspects. Rev Med Interne 20(12):1114–1122

    Article  PubMed  CAS  Google Scholar 

  16. Glezer A, D’Alva CB, Salgado LR, Musolino NR, Serafini P, Vieira JG, Bronstein MD (2002) Pitfalls in pituitary diagnosis: peculiarities of three cases. Clin Endocrinol (Oxf) 57(1):135–139

    Article  CAS  Google Scholar 

  17. Edmister KA, Sundaram M (2002) Oncogenic osteomalacia. Semin Musculoskelet Radiol 6(3):191–196

    Article  PubMed  Google Scholar 

  18. Prader A, Illig R, Uehlinger E, Stalder G (1959) Rickets following bone tumor. Helv Paediatr Acta 14:554–565

    PubMed  CAS  Google Scholar 

  19. Sahin M, Basoglu T, Albayrak S, Canbaz F, Yapici O (2001) Pentavalent technetium-99 m DMSA uptake in pseudofractures of osteomalacia. Clin Nucl Med 26(1):62–64

    Article  PubMed  CAS  Google Scholar 

  20. Garcia CA, Spencer RP (2002) Bone and In-111 octreotide imaging in oncogenic osteomalacia: a case report. Clin Nucl Med 27(8):582–583

    Article  PubMed  Google Scholar 

  21. Ross DS (1994) Hyperthyroidism, thyroid hormone therapy, and bone. Thyroid 4(3):319–326

    Article  PubMed  CAS  Google Scholar 

  22. Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M (2003) TSH is a negative regulator of skeletal remodeling. Cell 115(2):151–162

    Article  PubMed  CAS  Google Scholar 

  23. Simsek G, Karter Y, Aydin S, Uzun H (2003) Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism. Chin J Physiol 46(4):181–186

    PubMed  CAS  Google Scholar 

Download references

Acknowledgment

We would like particularly to thank Prof. Jean-François BONNEVILLE from the Department of Neuroradiology of the University Hospital of Besancon, France, for his valuable help.

Author information

Authors and Affiliations

  1. Service d’Endocrinologie-Diabétologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, 69003, France

    Alexis de Rougemont & Jean-Paul Riou

  2. Pôle Technique de Biologie, Hôpital du Bocage, CHU de Dijon, Dijon, 21000, France

    Alexis de Rougemont

  3. Service d’Imagerie Médicale, Hôpital du Bocage, CHU de Dijon, Dijon, 21000, France

    Marie-Gabrielle Mourot

  4. Service d’Endocrinologie, pavillon X, Hôpital Edouard Herriot, 5 place d’Arsonval, 69437, Lyon Cedex 03, France

    Alexis de Rougemont

Authors
  1. Alexis de Rougemont
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie-Gabrielle Mourot
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jean-Paul Riou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexis de Rougemont.

About this article

Cite this article

de Rougemont, A., Mourot, MG. & Riou, JP. Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man. J Bone Miner Metab 27, 513–518 (2009). https://doi.org/10.1007/s00774-009-0050-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-009-0050-1

Keywords

Search

Navigation