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Potential utility of high preoperative levels of serum type I collagen markers in postmenopausal women with primary hyperparathyroidism with respect to their short-term variations after parathyroidectomy

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Abstract

We evaluated short-term changes in serum amino-terminal procollagen propeptide (P1NP) and cross-linked C-terminal telopeptide (βCTX) of type I collagen after parathyroidectomy (PTX) in 41 postmenopausal women with primary hyperparathyroidism (PHPT). Serum levels of 25-hydroxyvitamin D, intact PTH, calcium, phosphate, albumin, creatinine, P1NP, and βCTX were measured before and 2 days after PTX. Their P1NP and βCTX levels were compared with those measured in 41 normally menstruating and 30 postmenopausal controls. Fifteen of these 41 women had both pre-surgery P1NP and βCTX concentrations above the upper limit noted in our postmenopausal controls [high turnover (HT) subgroup], while βCTX levels were solely above the upper limit lastly mentioned in 11 women [high bone resorption (HBR) subgroup]. In addition, these two markers were within the postmenopausal control range in 12 of them [normal turnover (NT) subgroup]. A more significant decrease in postoperative βCTX levels was observed in the 15 HT compared with the 12 NT PHPT women. The significant postoperative increase in P1NP levels observed in the 15 HT as well as in the 11 HBR was no longer significant in the 12 NT women. In conclusion, higher pre-surgery P1NP and βCTX levels in post-menopausal PHPT women are associated with a preferential activation of bone formation over bone resorption after PTX.

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Authors and Affiliations

  1. Departments of Hormonal Biology and Molecular Oncology, Saint-Louis University Hospital (AP-HP), 1 avenue Claude Vellefaux, 75475, Paris cedex 10, France

    Philippe Boudou & Fidaa Ibrahim

  2. Department of Rhumatology, Hôpital Cochin, Paris, France

    Catherine Cormier

  3. Department of Endocrine Surgery, Hôpital Saint-Louis, Paris, France

    Emile Sarfati

  4. Physiology laboratory, Hôpital Necker-Enfants malades, Assistance Publique, Hôpitaux de Paris (AP-HP), Paris, France

    Jean-Claude Souberbielle

  5. INSERM UMRS 872, Paris VI, France

    Philippe Boudou

Authors
  1. Philippe Boudou
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  3. Catherine Cormier
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  4. Emile Sarfati
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  5. Jean-Claude Souberbielle
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Correspondence to Philippe Boudou.

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Boudou, P., Ibrahim, F., Cormier, C. et al. Potential utility of high preoperative levels of serum type I collagen markers in postmenopausal women with primary hyperparathyroidism with respect to their short-term variations after parathyroidectomy. J Bone Miner Metab 27, 240–246 (2009). https://doi.org/10.1007/s00774-008-0033-7

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  • DOI: https://doi.org/10.1007/s00774-008-0033-7

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