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Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism

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Abstract

The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka, Osaka, 545-8585, Japan

    Yuuki Imai & Kunio Takaoka

  2. Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan

    Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto & Shigeaki Kato

  3. ERATO, Japan Science and Technology Agency, Tokyo, Japan

    Takashi Nakamura, Takahiro Matsumoto & Shigeaki Kato

Authors
  1. Yuuki Imai
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  2. Takashi Nakamura
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  3. Takahiro Matsumoto
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  4. Kunio Takaoka
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  5. Shigeaki Kato
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Corresponding author

Correspondence to Yuuki Imai.

Additional information

Y. Imai is a recipient of the 2007 JSBMR Research Encouragement Award.

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Imai, Y., Nakamura, T., Matsumoto, T. et al. Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism. J Bone Miner Metab 27, 127–130 (2009). https://doi.org/10.1007/s00774-008-0021-y

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  • DOI: https://doi.org/10.1007/s00774-008-0021-y

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