Abstract
Calciphylaxis is a rare disorder with high mortality, which commonly occurs, but not limited to, patients with end-stage renal disease. We present a successful case in which a patient survived this serious disorder of vasculopathy, highlighting the physical and emotional morbidities associated with this condition and alerting physicians of the key elements in its management. Further understanding of calciphylaxis may advance our knowledge in endotheliopathy and vascular ossification.
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References
Angelis M, Wong LL, Myers SA, Wong LM (1997) Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery 122:1083–1089
Fine A, Zacharias J (2002) Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int 61:2210–2217
Mehta RL, Scott G, Sloand JA, Francis CW (1990) Skin necrosis associated with acquired protein C deficiency in patients with renal failure and calciphylaxis. Am J Med 88:252–257
Wraight PR, Lawrence SM, Campbell DA, Colman PG (2005) Creation of a multidisciplinary, evidence based, clinical guideline for the assessment, investigation and management of acute diabetes related foot complications. Diabet Med 22:127–136
Cowper SE, Robin HS, Steinberg SM, Su LD et al (2000) Scleromyxoedema-like cutaneous diseases in renal-dialysis patients. Lancet 16:1000–1001
Levin A, Mehta RL, Goldstein MB (1993) Mathematical formulation to help identify the patient at risk of ischemic tissue necrosis: a potentially lethal complication of chronic renal failure. Am J Nephrol 13:448–453
Basile C, Montanaro A, Masi M, Pati G, De Maio P, Gismondi A (2002) Hyperbaric oxygen therapy for calcific uremic arteriolopathy: a case series. J Nephrol 15:676–680
Garg AX, Blake PG, Clark WF, Clase CM, Haynes RB, Moist LM (2001) Association between renal insufficiency and malnutrition in older adults: results from the NHANES III. Kidney Int 60:1867–1874
Owen WF Jr, Lew NL, Liu Y, Lowrie EG, Lazarus JM (1993) The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 329:1001–1006
Budisavljevic MN, Cheek D, Ploth DW (1996) Calciphylaxis in chronic renal failure. J Am Soc Nephrol 7:978–982
Arch-Ferrer JE, Beenken SW, Rue LW, Bland KI et al (2003) Therapy for calciphylaxis: an outcome analysis. Surgery 134:941–944
Velasco N, MacGregor MS, Innes A, MacKay IG (2001) Successful treatment of calciphylaxis with cinacalcet: an alternative to parathyroidectomy? Nephrol Dial Transplant 21:1999–2004
Guerra G, Shah RC, Ross EA (2005) Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrol Dial Transplant 20:1260–1262
Monney P, Nguyen QV, Perroud H, Descombes E (2004) Rapid improvement of calciphylaxis after intravenous pamidronate therapy in a patient with chronic renal failure. Nephrol Dial Transplant 19:2130–2132
Hayden MR, Sowers JR, Tyagi SC (2005) The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded. Cardiovasc Diabetol 28:9
Sambrook PN, Chen CJ, March L, Cameron ID et al (2006) High bone turnover is an independent predictor of mortality in the frail elderly. J Bone Miner Res 21:549–555
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Lee, P., Sevastos, J. & Campbell, L.V. Surviving calciphylaxis. J Bone Miner Metab 27, 247–250 (2009). https://doi.org/10.1007/s00774-008-0016-8
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DOI: https://doi.org/10.1007/s00774-008-0016-8