Skip to main content
Log in

Pelvic insufficiency fracture associated with severe suppression of bone turnover by alendronate therapy

  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.


  1. JR Tucci RP Tonino RD Emkey CA Peverly U Kher AC Santora Suffix2nd (1996) ArticleTitleEffect of three years of oral alendronate treatment in postmenopausal women with osteoporosis Am J Med 101 488–501 Occurrence Handle8948272 Occurrence Handle10.1016/S0002-9343(96)00282-3 Occurrence Handle1:CAS:528:DyaK28XnsFOmsrg%3D

    Article  PubMed  CAS  Google Scholar 

  2. JP Devogelaer H Broll R Correa-Rotter DC Cumming CN De Deuxchaisnes et al. (1996) ArticleTitleOral alendronate induces progressive increases in bone mass of the spine, hip, and total body over 3 years in postmenopausal women with osteoporosis Bone 18 141–150 Occurrence Handle8833208 Occurrence Handle10.1016/8756-3282(95)00436-X Occurrence Handle1:CAS:528:DyaK28XisVGjsL4%3D

    Article  PubMed  CAS  Google Scholar 

  3. DM Black SR Cummings DB Karpf JA Cauley DE Thompson MC Nevitt DC Bauer HK Genant WL Haskell R Marcus SM Ott JC Torner SA Quandt TF Reiss KE Ensrud (1996) ArticleTitleRandomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group Lancet 348 1535–1541 Occurrence Handle8950879 Occurrence Handle10.1016/S0140-6736(96)07088-2 Occurrence Handle1:CAS:528:DyaK2sXisFCktQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  4. UA Liberman SR Weiss J Broll HW Minne H Quan NH Bell J Rodriguez-Portales RW Downs SuffixJr J Dequeker M Favus E Seeman RR Recker T Capizzi AC Santora SuffixII A Lombardi RY Shah LJ Hirsch DB Karpf (1995) ArticleTitleEffect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group N Engl J Med 333 1437–1443 Occurrence Handle7477143 Occurrence Handle10.1056/NEJM199511303332201 Occurrence Handle1:CAS:528:DyaK28XkslehtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  5. SR Cummings DM Black DE Thompson WB Applegate E Barrett-Connor TA Musliner L Palermo R Prineas SM Rubin JC Scott T Vogt R Wallace AJ Yates AZ LaCroix (1998) ArticleTitleEffect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial Jama 280 2077–2082 Occurrence Handle9875874 Occurrence Handle10.1001/jama.280.24.2077 Occurrence Handle1:CAS:528:DyaK1MXjsVWruw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  6. HA Pols D Felsenberg DA Hanley J Stepan M Munoz-Torres TJ Wilkin G Qin-sheng AM Galich K Vandormael AJ Yates B Stych (1999) ArticleTitleMultinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group Osteoporosis Int 9 461–468 Occurrence Handle10.1007/PL00004171 Occurrence Handle1:CAS:528:DyaK1MXkt1CktrY%3D

    Article  CAS  Google Scholar 

  7. KE Ensrud DM Black L Palermo DC Bauer E Barrett-Connor SA Quandt DE Thompson DB Karpf (1997) ArticleTitleTreatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial Arch Intern Med 157 2617–2624 Occurrence Handle9531231 Occurrence Handle10.1001/archinte.157.22.2617 Occurrence Handle1:CAS:528:DyaK2sXotVCksrg%3D

    Article  PubMed  CAS  Google Scholar 

  8. HG Bone D Hosking JP Devogelaer JR Tucci RD Emkey RP Tonino JA Rodriguez-Portales RW Downs J Gupta AC Santora UA Liberman (2004) ArticleTitleTen years' experience with alendronate for osteoporosis in postmenopausal women N Engl J Med 350 1189–1199 Occurrence Handle15028823 Occurrence Handle10.1056/NEJMoa030897 Occurrence Handle1:CAS:528:DC%2BD2cXit12rsLc%3D

    Article  PubMed  CAS  Google Scholar 

  9. KE Ensrud EL Barrett-Connor A Schwartz AC Santora DC Bauer S Suryawanshi A Feldstein WL Haskell MC Hochberg JC Torner A Lombardi DM Black (2004) ArticleTitleRandomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension J Bone Miner Res 19 1259–1269 Occurrence Handle15231012 Occurrence Handle10.1359/JBMR.040326 Occurrence Handle1:CAS:528:DC%2BD2cXntFGqur0%3D

    Article  PubMed  CAS  Google Scholar 

  10. T Mashiba T Hirano CH Turner MR Forwood CC Johnston DB Burr (2000) ArticleTitleSuppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib J Bone Miner Res 15 613–620 Occurrence Handle10780852 Occurrence Handle10.1359/jbmr.2000.15.4.613 Occurrence Handle1:CAS:528:DC%2BD3cXisFWmtr4%3D

    Article  PubMed  CAS  Google Scholar 

  11. T Mashiba CH Turner T Hirano MR Forwood CC Johnston DB Burr (2001) ArticleTitleEffects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles Bone 28 524–531 Occurrence Handle11344052 Occurrence Handle10.1016/S8756-3282(01)00414-8 Occurrence Handle1:CAS:528:DC%2BD3MXjtlChsLk%3D

    Article  PubMed  CAS  Google Scholar 

  12. SM Ott (2005) ArticleTitleLong-term safety of bisphosphonates J Clin Endocrinol Metab 90 1897–1899 Occurrence Handle15758064 Occurrence Handle10.1210/jc.2005-0057 Occurrence Handle1:CAS:528:DC%2BD2MXisVOhu7w%3D

    Article  PubMed  CAS  Google Scholar 

  13. SM Ott (2001) ArticleTitleFractures after long-term alendronate therapy J Clin Endocrinol Metab 86 1835 Occurrence Handle11297626 Occurrence Handle10.1210/jc.86.4.1835 Occurrence Handle1:CAS:528:DC%2BD3MXivVCksbs%3D

    Article  PubMed  CAS  Google Scholar 

  14. CV Odvina JE Zerwekh DS Rao N Maalouf FA Gottschalk CY Pak (2005) ArticleTitleSeverely suppressed bone turnover: a potential complication of alendronate therapy J Clin Endocrinol Metab 90 1294–1301 Occurrence Handle15598694 Occurrence Handle10.1210/jc.2004-0952 Occurrence Handle1:CAS:528:DC%2BD2MXisVOhsr0%3D

    Article  PubMed  CAS  Google Scholar 

  15. AM Parfitt (2003) ArticleTitleRenal bone disease: a new conceptual framework for the interpretation of bone histomorphometry Curr Opin Nephrol Hypertens 12 387–403 Occurrence Handle12815335 Occurrence Handle10.1097/00041552-200307000-00007

    Article  PubMed  Google Scholar 

  16. JD Currey (1984) ArticleTitleEffects of differences in mineralization on the mechanical properties of bone Phil Trans R Soc London B Biol Sci 304 509–518 Occurrence Handle10.1098/rstb.1984.0042 Occurrence Handle1:STN:280:DyaL2c7ksFWnug%3D%3D

    Article  CAS  Google Scholar 

  17. AA De Smet JR Neff (1985) ArticleTitlePubic and sacral insufficiency fractures: clinical course and radiologic findings Am J Roentgenol 145 601–606 Occurrence Handle1:STN:280:DyaL2M3nsFyltw%3D%3D

    CAS  Google Scholar 

  18. R Schneider J Yacovone B Ghelman (1985) ArticleTitleUnsuspected sacral fractures: detection by radionuclide bone scanning Am J Roentgenol 144 337–341 Occurrence Handle1:STN:280:DyaL2M%2Fptl2jsA%3D%3D

    CAS  Google Scholar 

  19. T Ries (1983) ArticleTitleDetection of osteoporotic sacral fractures with radionuclides Radiology 146 783–785 Occurrence Handle6828693 Occurrence Handle1:STN:280:DyaL3s7ksFWhsA%3D%3D

    PubMed  CAS  Google Scholar 

  20. K Takahara M Kamimura H Nakagawa S Uchiyama (2004) ArticleTitleChanges in biochemical markers of bone in patients with insufficiency fractures J Bone Miner Metab 22 618–625 Occurrence Handle15490274 Occurrence Handle10.1007/s00774-004-0532-0

    Article  PubMed  Google Scholar 

  21. RR Recker DB Kimmel AM Parfitt KM Davies N Keshawartz S Hinders (1988) ArticleTitleStatic and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females J Bone Miner Res 3 133–144 Occurrence Handle3213608 Occurrence Handle1:STN:280:DyaL1M7gt1KrtA%3D%3D Occurrence Handle10.1002/jbmr.5650030203

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kazuhiro Imai.

About this article

Cite this article

Imai, K., Yamamoto, S., Anamizu, Y. et al. Pelvic insufficiency fracture associated with severe suppression of bone turnover by alendronate therapy. J Bone Miner Metab 25, 333–336 (2007).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

Key words