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Negative autoregulation of RANKL and c-Src signaling in osteoclasts

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References

  1. DM Anderson E Maraskovsky WL Billingsley WC Dougall ME Tometsko ER Roux MC Teepe RF DuBose D Cosman L Galibert (1997) ArticleTitleA homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Nature (Lond) 390 175–179 Occurrence Handle10.1038/36593 Occurrence Handle1:CAS:528:DyaK2sXnsVOgurY%3D

    Article  CAS  Google Scholar 

  2. BG Darnay V Haridas J Ni PA Moore BB Aggarwal (1998) ArticleTitleCharacterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase J Biol Chem 273 20551–20555 Occurrence Handle9685412 Occurrence Handle10.1074/jbc.273.32.20551 Occurrence Handle1:CAS:528:DyaK1cXlsVWgu7w%3D

    Article  PubMed  CAS  Google Scholar 

  3. BR Wong R Josien SY Lee M Vologodskaia RM Steinman Y Choi (1998) ArticleTitleThe TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor J Biol Chem 273 28355–28359 Occurrence Handle9774460 Occurrence Handle10.1074/jbc.273.43.28355 Occurrence Handle1:CAS:528:DyaK1cXntVClsL4%3D

    Article  PubMed  CAS  Google Scholar 

  4. N Kim PR Odgren DK Kim SC Marks SuffixJr Y Choi (2000) ArticleTitleDiverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene Proc Natl Acad Sci U S A 97 10905–10910 Occurrence Handle10984520 Occurrence Handle10.1073/pnas.200294797 Occurrence Handle1:CAS:528:DC%2BD3cXnt1ahsLw%3D

    Article  PubMed  CAS  Google Scholar 

  5. J Li I Sarosi XQ Yan S Morony C Capparelli et al. (2000) ArticleTitleRANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism Proc Natl Acad Sci U S A 97 1566–1571 Occurrence Handle10677500 Occurrence Handle10.1073/pnas.97.4.1566 Occurrence Handle1:CAS:528:DC%2BD3cXhsFCrsL4%3D

    Article  PubMed  CAS  Google Scholar 

  6. A Naito S Azuma S Tanaka T Miyazaki S Takaki K Takatsu K Nakao K Nakamura M Katsuki T Yamamoto J Inoue (1999) ArticleTitleSevere osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice Genes Cells 4 353–362 Occurrence Handle10421844 Occurrence Handle10.1046/j.1365-2443.1999.00265.x Occurrence Handle1:CAS:528:DyaK1MXltlekt7s%3D

    Article  PubMed  CAS  Google Scholar 

  7. MA Lomaga WC Yeh I Sarosi GS Duncan C Furlonger et al. (1999) ArticleTitleTRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling Genes Dev 13 1015–1024 Occurrence Handle10215628 Occurrence Handle1:CAS:528:DyaK1MXivFGkurY%3D

    PubMed  CAS  Google Scholar 

  8. SL Teitelbaum FP Ross (2003) ArticleTitleGenetic regulation of osteoclast development and function Nat Rev Genet 4 638–649 Occurrence Handle12897775 Occurrence Handle10.1038/nrg1122 Occurrence Handle1:CAS:528:DC%2BD3sXlvFaqtrY%3D

    Article  PubMed  CAS  Google Scholar 

  9. N Bucay I Sarosi CR Dunstan S Morony J Tarpley C Capparelli S Scully HL Tan W Xu DL Lacey WJ Boyle WS Simonet (1998) ArticleTitleOsteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification Genes Dev 12 1260–1268 Occurrence Handle9573043 Occurrence Handle1:CAS:528:DyaK1cXjtVejsrs%3D

    PubMed  CAS  Google Scholar 

  10. T Wada T Nakashima N Hiroshi JM Penninger (2006) ArticleTitleRANKL-RANK signaling in osteoclastogenesis and bone disease Trends Mol Med 12 17–25 Occurrence Handle16356770 Occurrence Handle10.1016/j.molmed.2005.11.007 Occurrence Handle1:CAS:528:DC%2BD28XmsVykug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. HC Blair LJ Robinson M Zaidi (2005) ArticleTitleOsteoclast signalling pathways Biochem Biophys Res Commun 328 728–738 Occurrence Handle15694407 Occurrence Handle10.1016/j.bbrc.2004.11.077 Occurrence Handle1:CAS:528:DC%2BD2MXhtVKhtrs%3D

    Article  PubMed  CAS  Google Scholar 

  12. S Tanaka I Nakamura J Inoue H Oda K Nakamura (2003) ArticleTitleSignal transduction pathways regulating osteoclast differentiation and function J Bone Miner Metab 21 123–133 Occurrence Handle12720046 Occurrence Handle10.1007/s007740300021

    Article  PubMed  Google Scholar 

  13. N Ishida K Hayashi M Hoshijima T Ogawa S Koga Y Miyatake M Kumegawa T Kimura T Takeya (2002) ArticleTitleLarge scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator J Biol Chem 277 41147–41156 Occurrence Handle12171919 Occurrence Handle10.1074/jbc.M205063200 Occurrence Handle1:CAS:528:DC%2BD38XnvFymsL0%3D

    Article  PubMed  CAS  Google Scholar 

  14. H Takayanagi S Kim T Koga H Nishina M Isshiki H Yoshida A Saiura M Isobe T Yokochi J Inoue EF Wagner TW Mak T Kodama T Taniguchi (2002) ArticleTitleInduction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts Dev Cell 3 889–901 Occurrence Handle12479813 Occurrence Handle10.1016/S1534-5807(02)00369-6 Occurrence Handle1:CAS:528:DC%2BD38XpslClsL8%3D

    Article  PubMed  CAS  Google Scholar 

  15. N Ishida K Hayashi A Hattori K Yogo T Kimura T Takeya (2006) ArticleTitleCCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration J Bone Miner Res 21 48–57 Occurrence Handle16355273 Occurrence Handle10.1359/JBMR.051001 Occurrence Handle1:CAS:528:DC%2BD28Xpt1SntQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. M Asagiri K Sato T Usami S Ochi H Nishina H Yoshida I Morita EF Wagner TW Mak E Serfling H Takayanagi (2005) ArticleTitleAutoamplification of NFATc1 expression determines its essential role in bone homeostasis J Exp Med 202 1261–1269 Occurrence Handle16275763 Occurrence Handle10.1084/jem.20051150 Occurrence Handle1:CAS:528:DC%2BD2MXht1Sntr%2FE

    Article  PubMed  CAS  Google Scholar 

  17. TN Crotti M Flannery NC Walsh JD Fleming SR Goldring KP McHugh (2006) ArticleTitleNFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation Gene (Amst) 372 92–102 Occurrence Handle1:CAS:528:DC%2BD28Xjslyjsro%3D

    CAS  Google Scholar 

  18. M Matsumoto M Kogawa S Wada H Takayanagi M Tsujimoto S Katayama K Hisatake Y Nogi (2004) ArticleTitleEssential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1 J Biol Chem 279 45969–45979 Occurrence Handle15304486 Occurrence Handle10.1074/jbc.M408795200 Occurrence Handle1:CAS:528:DC%2BD2cXovVCnt7s%3D

    Article  PubMed  CAS  Google Scholar 

  19. Y Kim K Sato M Asagiri I Morita K Soma H Takayanagi (2005) ArticleTitleContribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis J Biol Chem 280 32905–32913 Occurrence Handle16046394 Occurrence Handle10.1074/jbc.M505820200 Occurrence Handle1:CAS:528:DC%2BD2MXhtVWiurrM

    Article  PubMed  CAS  Google Scholar 

  20. K Matsuo DL Galson C Zhao L Peng C Laplace KZQ Wang MA Bachler H Amano H Aburatani H Ishikawa EF Wagner (2004) ArticleTitleNuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos J Biol Chem 279 26475–26480 Occurrence Handle15073183 Occurrence Handle10.1074/jbc.M313973200 Occurrence Handle1:CAS:528:DC%2BD2cXkvVWgtr4%3D

    Article  PubMed  CAS  Google Scholar 

  21. K Kim JH Kim J Lee HM Jin SH Lee DE Fisher H Kook KK Kim Y Choi N Kim (2005) ArticleTitleNuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis J Biol Chem 280 35209–35216 Occurrence Handle16109714 Occurrence Handle10.1074/jbc.M505815200 Occurrence Handle1:CAS:528:DC%2BD2MXhtFWmtbnM

    Article  PubMed  CAS  Google Scholar 

  22. F Ikeda R Nishimura T Matsubara S Tanaka J Inoue SV Reddy K Hata K Yamashita T Hiraga T Watanabe T Kukita K Yoshioka A Rao T Yoneda (2004) ArticleTitleCritical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation J Clin Invest 114 475–484 Occurrence Handle15314684 Occurrence Handle10.1172/JCI200419657 Occurrence Handle1:CAS:528:DC%2BD2cXmvVemu7Y%3D

    Article  PubMed  CAS  Google Scholar 

  23. S Umeda WG Beamer K Takagi M Naito S Hayashi H Yonemitsu T Yi LD Shultz (1999) ArticleTitleDeficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density Am J Pathol 155 223–233 Occurrence Handle10393854 Occurrence Handle1:CAS:528:DyaK1MXkslegtbw%3D

    PubMed  CAS  Google Scholar 

  24. K Aoki E Didomenico NA Sims K Mukhopadhyay L Neff A Houghton M Amling JB Levy WC Horne R Baron (1999) ArticleTitleThe tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice Bone (NY) 25 261–267 Occurrence Handle1:CAS:528:DyaK1MXls1WiurY%3D

    CAS  Google Scholar 

  25. HE Chen S Chang T Trub BG Neel (1996) ArticleTitleRegulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1 Mol Cell Biol 16 3685–3697 Occurrence Handle8668185 Occurrence Handle1:CAS:528:DyaK28XjvVWntbY%3D

    PubMed  CAS  Google Scholar 

  26. Z Zhang E Jimi AL Bothwell (2003) ArticleTitleReceptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis J Immunol 171 3620–3626 Occurrence Handle14500659 Occurrence Handle1:CAS:528:DC%2BD3sXnvFSrtLk%3D

    PubMed  CAS  Google Scholar 

  27. DB Stetson R Medzhitov (2006) ArticleTitleType I interferons in host defense Immunity 25 373–381 Occurrence Handle16979569 Occurrence Handle10.1016/j.immuni.2006.08.007 Occurrence Handle1:CAS:528:DC%2BD28XhtVOjtL%2FI

    Article  PubMed  CAS  Google Scholar 

  28. H Takayanagi S Kim K Matsuo H Suzuki T Suzuki K Sato T Yokochi H Oda K Nakamura N Ida EF Wagner T Taniguchi (2002) ArticleTitleRANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta Nature (Lond) 416 744–749 Occurrence Handle10.1038/416744a Occurrence Handle1:CAS:528:DC%2BD38XjtVKksLo%3D

    Article  CAS  Google Scholar 

  29. LF Coelho G Magno de Freitas Almeida FJ Mennechet A Blangy G Uze (2005) ArticleTitleInterferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression Proc Natl Acad Sci U S A 102 11917–11922 Occurrence Handle16081539 Occurrence Handle10.1073/pnas.0502188102 Occurrence Handle1:CAS:528:DC%2BD2MXpsFGgurc%3D

    Article  PubMed  CAS  Google Scholar 

  30. H Zheng X Yu P Collin-Osdoby P Osdoby (2006) ArticleTitleRANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone resorption J Biol Chem 281 15809–15820 Occurrence Handle16613848 Occurrence Handle10.1074/jbc.M513225200 Occurrence Handle1:CAS:528:DC%2BD28Xlt1CktLo%3D

    Article  PubMed  CAS  Google Scholar 

  31. T Hayashi T Kaneda Y Toyama M Kumegawa Y Hakeda (2002) ArticleTitleRegulation of receptor activator of NF-kappa B ligand-induced osteoclastogenesis by endogenous interferon-beta (INF-beta) and suppressors of cytokine signaling (SOCS). The possible counteracting role of SOCSs- in IFN-beta-inhibited osteoclast formation J Biol Chem 277 27880–27886 Occurrence Handle12023971 Occurrence Handle10.1074/jbc.M203836200 Occurrence Handle1:CAS:528:DC%2BD38XlvFKgt78%3D

    Article  PubMed  CAS  Google Scholar 

  32. Becker KL, Müller B, Nylén ES, Cohen R, White JC, Snider RH Jr (2002) Calcitonin gene family of peptides: structure, molecular biology, and effects. In: vol 1, Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology, Academic Press, San Diego, pp 619–639

  33. JP Woodrow CJ Sharpe NJ Fudge AO Hoff RF Gagel CS Kovacs (2006) ArticleTitleCalcitonin plays a critical role in regulating skeletal mineral metabolism during lactation Endocrinology 147 4010–4021 Occurrence Handle16675524 Occurrence Handle10.1210/en.2005-1616 Occurrence Handle1:CAS:528:DC%2BD28Xpt1Sjt78%3D

    Article  PubMed  CAS  Google Scholar 

  34. P Jurdic F Saltel A Chabadel O Destaing (2006) ArticleTitlePodosome and sealing zone: specificity of the osteoclast model Eur J Cell Biol 85 195–202 Occurrence Handle16546562 Occurrence Handle10.1016/j.ejcb.2005.09.008 Occurrence Handle1:CAS:528:DC%2BD28Xkt1Olurw%3D

    Article  PubMed  CAS  Google Scholar 

  35. L Spinardi PC Marchisio (2006) ArticleTitlePodosomes as smart regulators of cellular adhesion Eur J Cell Biol 85 191–194 Occurrence Handle16546561 Occurrence Handle10.1016/j.ejcb.2005.08.005 Occurrence Handle1:CAS:528:DC%2BD28Xkt1Olur8%3D

    Article  PubMed  CAS  Google Scholar 

  36. SM Thomas JS Brugge (1997) ArticleTitleCellular functions regulated by Src family kinases Annu Rev Cell Dev Biol 13 513–609 Occurrence Handle9442882 Occurrence Handle10.1146/annurev.cellbio.13.1.513 Occurrence Handle1:CAS:528:DyaK1cXisFSrsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  37. N Kumagai K Ohno R Tameshige M Hoshijima K Yogo N Ishida T Takeya (2004) ArticleTitleInduction of mouse c-src in RAW264 cells is dependent on AP-1 and NF-kappaB and important for progression to multinucleated cell formation Biochem Biophys Res Commun 325 758–768 Occurrence Handle15541355 Occurrence Handle10.1016/j.bbrc.2004.10.094 Occurrence Handle1:CAS:528:DC%2BD2cXpslKgu78%3D

    Article  PubMed  CAS  Google Scholar 

  38. P Soriano C Montgomery R Geske A Bradley (1991) ArticleTitleTargeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice Cell 64 693–702 Occurrence Handle1997203 Occurrence Handle10.1016/0092-8674(91)90499-O Occurrence Handle1:CAS:528:DyaK3MXhtlOht7g%3D

    Article  PubMed  CAS  Google Scholar 

  39. C Lowe T Yoneda BF Boyce H Chen GR Mundy P Soriano (1993) ArticleTitleOsteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts Proc Natl Acad Sci U S A 90 4485–4489 Occurrence Handle7685105 Occurrence Handle10.1073/pnas.90.10.4485 Occurrence Handle1:CAS:528:DyaK3sXmt1egtb0%3D

    Article  PubMed  CAS  Google Scholar 

  40. BF Boyce T Yoneda C Lowe P Soriano GR Mundy (1992) ArticleTitleRequirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice J Clin Invest 90 1622–1627 Occurrence Handle1383278 Occurrence Handle1:CAS:528:DyaK38XmtlWjt78%3D

    PubMed  CAS  Google Scholar 

  41. PT Lakkakorpi I Nakamura M Young L Lipfert GA Rodan LT Duong (2001) ArticleTitleAbnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts J Cell Sci 114 149–160 Occurrence Handle11112699 Occurrence Handle1:CAS:528:DC%2BD3MXhtVSgsLs%3D

    PubMed  CAS  Google Scholar 

  42. S Tanaka M Amling L Neff A Peyman E Uhlmann JB Levy R Baron (1996) ArticleTitlec-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption Nature (Lond) 383 528–531 Occurrence Handle10.1038/383528a0 Occurrence Handle1:CAS:528:DyaK28Xmt1Gku7k%3D

    Article  CAS  Google Scholar 

  43. LT Duong PT Lakkakorpi I Nakamura M Machwate RM Nagy GA Rodan (1998) ArticleTitlePYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase J Clin Invest 102 881–892 Occurrence Handle9727056 Occurrence Handle1:CAS:528:DyaK1cXlvVCqt70%3D Occurrence Handle10.1172/JCI3212

    Article  PubMed  CAS  Google Scholar 

  44. I Nakamura E Jimi LT Duong T Sasaki N Takahashi GA Rodan T Suda (1998) ArticleTitleTyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts J Biol Chem 273 11144–11149 Occurrence Handle9556601 Occurrence Handle10.1074/jbc.273.18.11144 Occurrence Handle1:CAS:528:DyaK1cXjtFGkurY%3D

    Article  PubMed  CAS  Google Scholar 

  45. A Sanjay A Houghton L Neff E DiDomenico C Bardelay E Antoine J Levy J Gailit D Bowtell WC Horne R Baron (2001) ArticleTitleCbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility J Cell Biol 152 181–195 Occurrence Handle11149930 Occurrence Handle10.1083/jcb.152.1.181 Occurrence Handle1:CAS:528:DC%2BD3MXjslyhsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  46. T Miyazaki A Sanjay L Neff S Tanaka WC Horne R Baron (2004) ArticleTitleSrc kinase activity is essential for osteoclast function J Biol Chem 279 17660–17666 Occurrence Handle14739300 Occurrence Handle10.1074/jbc.M311032200 Occurrence Handle1:CAS:528:DC%2BD2cXjt1Gntbo%3D

    Article  PubMed  CAS  Google Scholar 

  47. S Koga K Yogo K Yoshikawa H Samori M Goto T Uchida N Ishida T Takeya (2005) ArticleTitlePhysical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro J Biol Chem 280 31564–31571 Occurrence Handle16020549 Occurrence Handle10.1074/jbc.M502703200 Occurrence Handle1:CAS:528:DC%2BD2MXpslaqu7k%3D

    Article  PubMed  CAS  Google Scholar 

  48. M Chellaiah C Fitzgerald U Alvarez K Hruska (1998) ArticleTitlec-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase J Biol Chem 273 11908–11916 Occurrence Handle9565618 Occurrence Handle10.1074/jbc.273.19.11908 Occurrence Handle1:CAS:528:DyaK1cXjt1ahtLc%3D

    Article  PubMed  CAS  Google Scholar 

  49. MA Chellaiah RS Biswas D Yuen UM Alvarez KA Hruska (2001) ArticleTitlePhosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin J Biol Chem 276 47434–47444 Occurrence Handle11577104 Occurrence Handle10.1074/jbc.M107494200 Occurrence Handle1:CAS:528:DC%2BD3MXpt1GmsbY%3D

    Article  PubMed  CAS  Google Scholar 

  50. PT Lakkakorpi G Wesolowski Z Zimolo GA Rodan SB Rodan (1997) ArticleTitlePhosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading Exp Cell Res 237 296–306 Occurrence Handle9434625 Occurrence Handle10.1006/excr.1997.3797 Occurrence Handle1:CAS:528:DyaK1cXjt1GgsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  51. JE Damen L Liu P Rosten RK Humphries AB Jefferson PW Majerus G Krystal (1996) ArticleTitleThe 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase Proc Natl Acad Sci U S A 93 1689–1693 Occurrence Handle8643691 Occurrence Handle10.1073/pnas.93.4.1689 Occurrence Handle1:CAS:528:DyaK28Xht1entLw%3D

    Article  PubMed  CAS  Google Scholar 

  52. MN Lioubin PA Algate S Tsai K Carlberg A Aebersold LR Rohrschneider (1996) ArticleTitlep150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity Genes Dev 10 1084–1095 Occurrence Handle8654924 Occurrence Handle10.1101/gad.10.9.1084 Occurrence Handle1:CAS:528:DyaK28XjtFajtbk%3D

    Article  PubMed  CAS  Google Scholar 

  53. LH Golden KL Insogna (2004) ArticleTitleThe expanding role of PI3-kinase in bone Bone (NY) 34 3–12 Occurrence Handle1:CAS:528:DC%2BD2cXnvVeqsA%3D%3D

    CAS  Google Scholar 

  54. S Takeshita N Namba JJ Zhao Y Jiang HK Genant MJ Silva MD Brodt CD Helgason J Kalesnikoff MJ Rauh RK Humphries G Krystal SL Teitelbaum FP Ross (2002) ArticleTitleSHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts Nat Med 8 943–949 Occurrence Handle12161749 Occurrence Handle10.1038/nm752 Occurrence Handle1:CAS:528:DC%2BD38Xms1ait70%3D

    Article  PubMed  CAS  Google Scholar 

  55. T Sugatani U Alvarez KA Hruska (2003) ArticleTitlePTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility J Biol Chem 278 5001–5008 Occurrence Handle12460992 Occurrence Handle10.1074/jbc.M209299200 Occurrence Handle1:CAS:528:DC%2BD3sXhtVKltrs%3D

    Article  PubMed  CAS  Google Scholar 

  56. K Yogo M Mizutamari K Mishima H Takenouchi N Ishida-Kitagawa T Sasaki T Takeya (2006) ArticleTitleSrc homology 2 (SH2)-containing 5′-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts Endocrinology 147 3307–3317 Occurrence Handle16601135 Occurrence Handle10.1210/en.2005-1309 Occurrence Handle1:CAS:528:DC%2BD28XmtlOrsrc%3D

    Article  PubMed  CAS  Google Scholar 

  57. WC Horne A Sanjay A Bruzzaniti R Baron (2005) ArticleTitleThe role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function Immunol Rev 208 106–125 Occurrence Handle16313344 Occurrence Handle10.1111/j.0105-2896.2005.00335.x Occurrence Handle1:CAS:528:DC%2BD28Xks1eitg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  58. WS Simonet DL Lacey CR Dunstan M Kelley MS Chang et al. (1997) ArticleTitleOsteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 309–319 Occurrence Handle9108485 Occurrence Handle10.1016/S0092-8674(00)80209-3 Occurrence Handle1:CAS:528:DyaK2sXislCgtLc%3D

    Article  PubMed  CAS  Google Scholar 

  59. E Tsuda M Goto S Mochizuki K Yano F Kobayashi T Morinaga K Higashio (1997) ArticleTitleIsolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis Biochem Biophys Res Commun 234 137–142 Occurrence Handle9168977 Occurrence Handle10.1006/bbrc.1997.6603 Occurrence Handle1:CAS:528:DyaK2sXjt1ynsLw%3D

    Article  PubMed  CAS  Google Scholar 

  60. H Yasuda N Shima N Nakagawa SI Mochizuki K Yano N Fujise Y Sato M Goto K Yamaguchi M Kuriyama T Kanno A Murakami E Tsuda T Morinaga K Higashio (1998) ArticleTitleIdentity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro Endocrinology 139 1329–1337 Occurrence Handle9492069 Occurrence Handle10.1210/en.139.3.1329

    Article  PubMed  Google Scholar 

  61. H Takayanagi K Ogasawara S Hida T Chiba S Murata K Sato A Takaoka T Yokochi H Oda K Tanaka K Nakamura T Taniguchi (2000) ArticleTitleT-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma Nature (Lond) 408 600–605 Occurrence Handle10.1038/35046102 Occurrence Handle1:CAS:528:DC%2BD3cXovFajs7c%3D

    Article  CAS  Google Scholar 

  62. JL Moreno M Kaczmarek AD Keegan M Tondravi (2003) ArticleTitleIL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL Blood 102 1078–1086 Occurrence Handle12689929 Occurrence Handle10.1182/blood-2002-11-3437 Occurrence Handle1:CAS:528:DC%2BD3sXlvFCmtLw%3D

    Article  PubMed  CAS  Google Scholar 

  63. E Abe RC Marians W Yu XB Wu T Ando Y Li J Iqbal L Eldeiry G Rajendren HC Blair TF Davies M Zaidi (2003) ArticleTitleTSH is a negative regulator of skeletal remodeling Cell 115 151–162 Occurrence Handle14567913 Occurrence Handle10.1016/S0092-8674(03)00771-2 Occurrence Handle1:CAS:528:DC%2BD3sXosFCqsL4%3D

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Keiichiro Yogo.

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Yogo, K., Ishida-Kitagawa, N. & Takeya, T. Negative autoregulation of RANKL and c-Src signaling in osteoclasts. J Bone Miner Metab 25, 205–210 (2007). https://doi.org/10.1007/s00774-007-0751-2

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