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Effects of pubertal development, height, weight, and grip strength on the bone mineral density of the lumbar spine and hip in peripubertal Japanese children: Kyoto kids increase density in the skeleton study (Kyoto KIDS study)

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Abstract

The effects of growth and pubertal development on the bone mineral density (BMD) of the lumbar spine and hip in peripubertal Japanese children were studied as a basis for evaluating the effects of modifiable factors on bone mass gain. The study comprised bone mass measurements in the lumbar spine (L2–4), femoral neck, and total hip using dual-energy X-ray absorptiometry as well as body size measurements and detailed interviews on medical history and pubertal status. The subjects were 404 first-grade students in three junior high schools (129 boys and 275 girls, mean age 12.8 ± 0.3 years) with no diseases or medication that would affect bone metabolism. BMD at each site showed an increasing trend with physical growth and sexual maturity. Significant positive correlations were observed between BMD at every skeletal site and height, weight, and grip strength in pre- and postpubertal boys and girls. In multiple regression analyses, pubertal development had a significant positive independent effect on BMD at every skeletal site in girls, but not in boys. Physical and pubertal development showed major effects on BMD, but the magnitude of these effects differed in boys and girls, even if they were of the same age. We conclude that confounding factors due to physical and pubertal development should be taken into consideration in different ways for boys and girls in investigations on the effects of environmental or behavioral factors on bone mass acquisition in peripubertal children.

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References

  1. SR Cummings JL Kelsey MC Nevitt KJ O'Dowd (1985) ArticleTitleEpidemiology of osteoporosis and osteoporotic fractures Epidemiol Rev 7 178–208 Occurrence Handle3902494

    PubMed  Google Scholar 

  2. JL Kelsey WS Browner DG Seeley MC Nevitt SR Cummings (1992) ArticleTitleRisk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group Am J Epidemiol 135 477–489 Occurrence Handle1570814

    PubMed  Google Scholar 

  3. SR Cummings D Black (1995) ArticleTitleBone mass measurements and risk of fracture in Caucasian women: a review of findings from prospective studies Am J Med 98 S24–S28 Occurrence Handle10.1016/S0002-9343(05)80041-5

    Article  Google Scholar 

  4. JP Bonjour G Theintz B Buchs D Slosman R Rizzoli (1991) ArticleTitleCritical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence J Clin Endocrinol Metab 73 555–563 Occurrence Handle1874933

    PubMed  Google Scholar 

  5. MA Hansen K Overgaard BJ Riis C Christiansen (1991) ArticleTitleRole of peak bone mass and bone loss in postmenopausal osteoporosis: 12-year study BMJ 303 961–964 Occurrence Handle1954420

    PubMed  Google Scholar 

  6. Y Takahashi K Minamitani Y Kobayashi M Minagawa T Yasuda H Niimi (1996) ArticleTitleSpinal and femoral bone mass accumulation during normal adolescence: comparison with female patients with sexual precocity and with hypogonadism J Clin Endocrinol Metab 81 1248–1253 Occurrence Handle10.1210/jc.81.3.1248 Occurrence Handle8772607

    Article  PubMed  Google Scholar 

  7. JP Sabatier G Guaydier-Souquieres A Benmalek C Marcelli (1999) ArticleTitleEvolution of lumbar bone mineral content during adolescence and adulthood: a longitudinal study in 395 healthy females 10–24 years of age and 206 premenopausal women Osteoporos Int 9 476–482 Occurrence Handle10.1007/s001980050173 Occurrence Handle10624453

    Article  PubMed  Google Scholar 

  8. R Eastell H Lambert (2002) ArticleTitleDiet and healthy bones Calcif Tissue Int 70 400–404 Occurrence Handle10.1007/s00223-001-0047-9 Occurrence Handle11960202

    Article  PubMed  Google Scholar 

  9. R Rizzoli JP Bonjour (1999) ArticleTitleDeterminants of peak bone mass and mechanisms of bone loss Osteoporos Int 9 Suppl 2 S17–S23 Occurrence Handle10525721

    PubMed  Google Scholar 

  10. RP Heaney S Abrams B Dawson-Hughes A Looker R Marcus V Matkovic C Weaver (2000) ArticleTitlePeak bone mass Osteoporos Int 11 985–1009 Occurrence Handle10.1007/s001980070020 Occurrence Handle11256898

    Article  PubMed  Google Scholar 

  11. JP Bonjour R Rizzoli (2001) Bone acquisition in adolescence R Marcus D Feldman J Kelsey (Eds) Osteoporosis EditionNumber2nd ed. Academic Press San Diego 621–638

    Google Scholar 

  12. LA Rubin GA Hawker VD Peltekova LJ Fielding R Ridout DE Cole (1999) ArticleTitleDeterminants of peak bone mass: clinical and genetic analyses in a young female Canadian cohort J Bone Miner Res 14 633–643 Occurrence Handle10234586

    PubMed  Google Scholar 

  13. J De Schepper MP Derde M Van den Broeck A Piepsz MH Jonckheer (1991) ArticleTitleNormative data for lumbar spine bone mineral content in children: influence of age, height, weight, and pubertal stage J Nucl Med 32 216–220 Occurrence Handle1992021

    PubMed  Google Scholar 

  14. SK Grimston K Morrison JA Harder DA Hanley (1992) ArticleTitleBone mineral density during puberty in western Canadian children Bone Miner 19 85–96 Occurrence Handle10.1016/0169-6009(92)90846-6 Occurrence Handle1422308

    Article  PubMed  Google Scholar 

  15. G Theintz B Buchs R Rizzoli D Slosman H Clavien PC Sizonenko JP Bonjour (1992) ArticleTitleLongitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects J Clin Endocrinol Metab 75 1060–1065 Occurrence Handle10.1210/jc.75.4.1060 Occurrence Handle1400871

    Article  PubMed  Google Scholar 

  16. H Kroger A Kotaniemi L Kroger E Alhava (1993) ArticleTitleDevelopment of bone mass and bone density of the spine and femoral neck – a prospective study of 65 children and adolescents Bone Miner 23 171–182 Occurrence Handle8148662

    PubMed  Google Scholar 

  17. K Rubin V Schirduan P Gendreau M Sarfarazi R Mendola G Dalsky (1993) ArticleTitlePredictors of axial and peripheral bone mineral density in healthy children and adolescents, with special attention to the role of puberty J Pediatr 123 863–870 Occurrence Handle8229518

    PubMed  Google Scholar 

  18. L del Rio A Carrascosa F Pons M Gusinye D Yeste FM Domenech (1994) ArticleTitleBone mineral density of the lumbar spine in white Mediterranean Spanish children and adolescents: changes related to age, sex, and puberty Pediatr Res 35 362–366 Occurrence Handle8190528

    PubMed  Google Scholar 

  19. PW Lu JN Briody GD Ogle K Morley IR Humphries J Allen R Howman-Giles D Sillence CT Cowell (1994) ArticleTitleBone mineral density of total body, spine, and femoral neck in children and young adults: a cross-sectional and longitudinal study J Bone Miner Res 9 1451–1458 Occurrence Handle7817830

    PubMed  Google Scholar 

  20. AM Boot MA de Ridder HA Pols EP Krenning SM de Muinck Keizer-Schrama (1997) ArticleTitleBone mineral density in children and adolescents: relation to puberty, calcium intake, and physical activity J Clin Endocrinol Metab 82 57–62 Occurrence Handle10.1210/jc.82.1.57 Occurrence Handle8989233

    Article  PubMed  Google Scholar 

  21. JC Cheng N Maffulli SS Leung WT Lee JT Lau KM Chan (1999) ArticleTitleAxial and peripheral bone mineral acquisition: a 3-year longitudinal study in Chinese adolescents Eur J Pediatr 158 506–512 Occurrence Handle10.1007/s004310051131 Occurrence Handle10378402

    Article  PubMed  Google Scholar 

  22. M Iki S Kagamimori Y Kagawa T Matsuzaki H Yoneshima F Marumo (2001) ArticleTitleBone mineral density of the spine, hip and distal forearm in representative samples of the Japanese female population: Japanese Population-Based Osteoporosis (JPOS) Study Osteoporos Int 12 529–537 Occurrence Handle10.1007/s001980170073 Occurrence Handle11527049

    Article  PubMed  Google Scholar 

  23. JrCC Johnston JZ Miller CW Slemenda TK Reister S Hui JC Christian M Peacock (1992) ArticleTitleCalcium supplementation and increases in bone mineral density in children N Engl J Med 327 82–87 Occurrence Handle1603140

    PubMed  Google Scholar 

  24. MJ Merrilees EJ Smart NL Gilchrist C Frampton JG Turner E Hooke RL March P Maguire (2000) ArticleTitleEffects of dairy food supplements on bone mineral density in teenage girls Eur J Nutr 39 256–262 Occurrence Handle10.1007/s003940070004 Occurrence Handle11395985

    Article  PubMed  Google Scholar 

  25. JP Bonjour T Chevalley P Ammann D Slosman R Rizzoli (2001) ArticleTitleGain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study Lancet 358 1208–1212 Occurrence Handle10.1016/S0140-6736(01)06342-5 Occurrence Handle11675056

    Article  PubMed  Google Scholar 

  26. DC Welten HC Kemper GB Post W Van Mechelen J Twisk P Lips GJ Teule (1994) ArticleTitleWeight-bearing activity during youth is a more important factor for peak bone mass than calcium intake J Bone Miner Res 9 1089–1096 Occurrence Handle7942156

    PubMed  Google Scholar 

  27. NK Henderson RI Price JH Cole DH Gutteridge CI Bhagat (1995) ArticleTitleBone density in young women is associated with body weight and muscle strength but not dietary intakes J Bone Miner Res 10 384–393 Occurrence Handle7785459

    PubMed  Google Scholar 

  28. P Nordstrom G Nordstrom R Lorentzon (1997) ArticleTitleCorrelation of bone density to strength and physical activity in young men with a low or moderate level of physical activity Calcif Tissue Int 60 332–337 Occurrence Handle10.1007/s002239900238 Occurrence Handle9075628

    Article  PubMed  Google Scholar 

  29. KA Witzke CM Snow (1999) ArticleTitleLean body mass and leg power best predict bone mineral density in adolescent girls Med Sci Sports Exerc 31 1558–1563 Occurrence Handle10.1097/00005768-199911000-00010 Occurrence Handle10589857

    Article  PubMed  Google Scholar 

  30. HA McKay DA Bailey RL Mirwald KS Davison RA Faulkner (1998) ArticleTitlePeak bone mineral accrual and age at menarche in adolescent girls: a 6-year longitudinal study J Pediatr 133 682–687 Occurrence Handle9821429

    PubMed  Google Scholar 

  31. PE Fournier R Rizzoli DO Slosman G Theintz JP Bonjour (1997) ArticleTitleAsynchrony between the rates of standing height gain and bone mass accumulation during puberty Osteoporos Int 7 525–532 Occurrence Handle10.1007/BF01623779 Occurrence Handle9604047

    Article  PubMed  Google Scholar 

  32. DA Bailey HA McKay RL Mirwald PR Crocker RA Faulkner (1999) ArticleTitleA six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the University of Saskatchewan Bone Mineral Accrual Study J Bone Miner Res 14 1672–1679 Occurrence Handle10491214

    PubMed  Google Scholar 

  33. National Stadium and School Health Center of Japan (2002) Diseases and Injuries at School: Basic Statistics (in Japanese). National Stadium and School Health Center of Japan, Tokyo

  34. M Matsueda K Takahashi Y Seino (2001) ArticleTitleThe effects of growth, maturation and life-style on acquiring bone strength during adolescence – a comparison between males and females (in Japanese) Jpn J School Health 43 199–210

    Google Scholar 

  35. Ministry of Education, Culture, Sports, Science and Technology (MEXT), Sports and Youth Bureau (2001) Report on Physical and Motor Ability survey in Fiscal Year 2000 (in Japanese). p 1–55

  36. M Hiroi (1997) ArticleTitleReport by the Subcommittee of Obesity and Sexual Function Among Japanese Adolescent Girls in Fiscal Year 1995–1996: interrelationships physique, menstrual cycle, change of body weight and ideal body weight among Japanese adolescent girls, by way of a questionnaire (in Japanese) Acta Obstet Gynaec Jpn 49 367–377

    Google Scholar 

  37. V Gilsanz (1998) ArticleTitleBone density in children: a review of the available techniques and indications Eur J Radiol 26 177–182 Occurrence Handle10.1016/S0720-048X(97)00093-4 Occurrence Handle9518226

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Kyoto University of Education, 1 Fukakusa Fujinomori, Fushimi-ku, Kyoto, 612-8522, Japan

    Hiroshi Naka

  2. Department of Public Health, Kinki University School of Medicine, Osaka-Sayama, Japan

    Masayuki Iki, Akemi Morita & Yukihiro Ikeda

Authors
  1. Hiroshi Naka
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  2. Masayuki Iki
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  3. Akemi Morita
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  4. Yukihiro Ikeda
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Correspondence to Hiroshi Naka.

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Naka, H., Iki, M., Morita, A. et al. Effects of pubertal development, height, weight, and grip strength on the bone mineral density of the lumbar spine and hip in peripubertal Japanese children: Kyoto kids increase density in the skeleton study (Kyoto KIDS study). J Bone Miner Metab 23, 463–469 (2005). https://doi.org/10.1007/s00774-005-0629-0

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  • DOI: https://doi.org/10.1007/s00774-005-0629-0

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