Abstract
We analyzed the relationship between the level of type-I collagen N-telopeptide (NTx) in urine (U-NTx) and bone mineral density (BMD) in patients with rheumatoid arthritis (RA). The subjects were 62 female patients with RA who had experienced the menopause 5 years or more before the study commenced, and who had not been treated for osteoporosis. The mean age of the subjects was 61.6 years and the mean disease duration was 13.3 years. They were classified for global functional status (classes I to IV), and then grouped based on the presence or absence of corticosteroid administration. Bone mineral density (BMD) and U-NTx levels were measured. In the presence of corticosteroid administration (CS group; n = 40), the mean level of U-NTx/creatinine (Cr) was 88.8 nM and the percent young adult mean (%YAM) for BMD was 71.2%. In the no corticosteroid (nCS group; n = 22), the values were 72.1 nM and 78.2%, respectively. The U-NTx/Cr value and %YAM were not significantly different between the CS group and the nCS group. A negative correlation was observed between the U-NTx/Cr value and %YAM in both groups (P = 0.005 and P = 0.0265). No significant difference was observed for the U-NTx/Cr value or %YAM between the CS and nCS groups, in any class. In the CS group, a positive correlation was observed between the U-NTx/Cr value and the total dose of corticosteroid (P = 0.001), and a negative correlation was observed between the %YAM and the total dose of corticosteroid (P = 0.003). These results suggested that preventive medical treatment for osteoporosis is required for RA patients in class III, irrespective of whether they have had corticosteroid administration.
Similar content being viewed by others
References
G Haugeberg T Uhlig JA Falch JI Halse TE Kvin (2000) ArticleTitleBone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo Country Rheumatoid Arthritis Register. Arthritis Rheum 43 522–530 Occurrence Handle1:STN:280:DC%2BD3c7ptFSrug%3D%3D
R Ramsey-Goldman JE Dunn CF Huang D Dunlop JE Rairie S Fitzgerald (1999) ArticleTitleFrequency of fractures in women with systemic lupus erythematosus: comparison with United States population data. Arthritis Rheum 42 882–890 Occurrence Handle1:STN:280:DyaK1M3lsFShsA%3D%3D
JD Adachi (1997) ArticleTitleCorticosteriod induced osteoporosis. Am J Med Sci 313 41–48 Occurrence Handle1:STN:280:ByiC2MvksVM%3D
J Dequeker K Maenau J Verwilghen (1995) ArticleTitleOsteoporosis in rheumatoid arthritis Clin Exp Rheumatol 133 21–26
InstitutionalAuthorNameAmerican College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis (2001) ArticleTitleRecommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 update Arthritis Rheum 44 1496–1503
D Bikle (1997) ArticleTitleBiochemical markers in the assessment of bone disease Am J Med 103 427–436 Occurrence Handle10.1016/S0002-9343(97)00137-X Occurrence Handle1:CAS:528:DyaK2sXnslyjsLY%3D Occurrence Handle9375712
R Swaminathan (2001) ArticleTitleBiochemical markers of bone turnover Clin Chim Acta 313 95–101 Occurrence Handle10.1016/S0009-8981(01)00656-8 Occurrence Handle1:CAS:528:DC%2BD3MXnvFGqtbs%3D Occurrence Handle11694245
AM al-Awadhi SO Olusi N al-Zaid (1998) ArticleTitleUrine levels of type I collagen cross-linked N-telopeptides and deoxypyridinoline correlate with disease activity in rheumatoid arthritis Clin Exp Rheumatol 16 569–572 Occurrence Handle1:STN:280:DyaK1cvlt1ensg%3D%3D Occurrence Handle9779304
FC Arnett SM Edworthy DA Bloch DJ McShane JF Freies NS Cooper (1988) ArticleTitleThe American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31 315–324 Occurrence Handle1:STN:280:BieC1M3nt1Q%3D
O Steinbrocker CH Traeger RC Batterman (1949) ArticleTitleTherapeutic criteria in rheumatoid arthritis JAMA 140 659–662
JR Kirwann (1995) ArticleTitleThe effect of glucocorticoids on joint destruction in rheumatoid arthritis N Engl J Med 333 142–146 Occurrence Handle10.1056/NEJM199507203330302 Occurrence Handle7791815
DL Conn (2001) ArticleTitleLow-dose prednisone is indicated as a standard treatment in patients with rheumatoid arthritis Arthritis Rheum 45 462–467 Occurrence Handle10.1002/1529-0131(200110)45:5<462::AID-ART366>3.0.CO;2-V Occurrence Handle1:CAS:528:DC%2BD3MXpt12lsb0%3D Occurrence Handle11642646
AA van Everdingen JW Jacobs Van Siewertsz DR Reesema JW Bijlsma (2002) ArticleTitleLow-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-smodifying properties, and side effects. A randomized, double-blind, placebo controlled clinical trial. Ann Intern Med 136 1–12 Occurrence Handle1:CAS:528:DC%2BD38XmtVajtQ%3D%3D
AA van Everdingen DR Siewertsz van Reesema JW Jacobs JW Bijlsma (2003) ArticleTitleLow-dose glucocorticoids in early rheumatoid arthritis: discordant effects on bone mineral density and fractures? Clin Exp Rheumatol 21 155–160 Occurrence Handle1:STN:280:DC%2BD3s3is1Wgug%3D%3D Occurrence Handle12747268
S Goemaere J Adachi F Hawkins N Lane P Poubelle K Saag (1996) ArticleTitleNonvertebral fracture and bone density in glucocorticoid-treated patients Arthritis Rheum 39 IssueIDs1 S88–98
NE Lane B Lukert (1998) ArticleTitleThe science and therapy of glucocorticoid–induced bone loss Endocrinol Metab Clin North Am 27 465–483 Occurrence Handle10.1016/S0889-8529(05)70017-7 Occurrence Handle1:CAS:528:DyaK1cXktl2murw%3D Occurrence Handle9669150
J Dequeker K Maenaut J Verwilghen R Westhovens (1995) ArticleTitleOsteoporosis in rheumatoid arthritis Clin Exp Rheumatol 13 IssueIDs12 S21–26 Occurrence Handle8846540
L Sinigaglia A Nervetti Q Mela G Bianchi A Del Puente O Di Munno B Frediani F Cantatore R Pellerito S Bartolone G La Montagna S Adami (2000) ArticleTitleA multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian study group on bone mass in rheumatoid arthritis J Rheumatol 27 2582–2589 Occurrence Handle1:STN:280:DC%2BD3M7otVOksg%3D%3D Occurrence Handle11093437
E Jimi I Nakamura LT Duong T Ikebe N Takahashi GA Rodan T Suda (1999) ArticleTitleInterleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts stromal cells. Exp Cell Res 247 84–93 Occurrence Handle10.1006/excr.1998.4320 Occurrence Handle1:CAS:528:DyaK1MXht12ku7w%3D
K Kobayashi N Takahashi E Jimi N Udagawa M Takami S Kotake N Nakagawa M Kinosaki K Yamaguchi N Shima H Yasuda T Morinaga K Higashio TJ Martin T Suda (2000) ArticleTitleTumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL RANK interaction. J Exp Med 191 275–286 Occurrence Handle1:CAS:528:DC%2BD3cXntFenug%3D%3D
KN Saidenbergie N Bessis SM Cohen MC De Vernejoul BM Christophe (2002) ArticleTitleOsteoprotegerin and inflammation Eur Cytokine Netw 13 144–153 Occurrence Handle12101070
R Eastell DM Reid J Compston C Cooper I Fogelman RM Francis DJ Hosking DW Purdie SH Ralston J Reeve RG Russell JC Stevenson DJ Torgerson (1998) ArticleTitleA UK Consensus Group on management of glucocorticoid-induced osteoporosis: an update. J Intern Med 244 271–292 Occurrence Handle1:CAS:528:DyaK1cXntFCit7w%3D
S Sohen M Kamiya H Kikuchi T Nonaka M Ueno H Fukuoka C Hamanishi (2001) ArticleTitleAnalysis of diagnostic criteria of generalized osteoporosis in patients with rheumatoid arthritis Clin Rheumatol Related Res 13 190–195
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Nonaka, T., Nishisaka, F., Fukuda, K. et al. Relationship between bone mineral density and urine level of NTx in rheumatoid arthritis. J Bone Miner Metab 23, 314–317 (2005). https://doi.org/10.1007/s00774-004-0605-0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00774-004-0605-0