Literatur
Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM (2017) Vascular cells in blood vessel wall development and disease. Adv Pharmacol 78:323–350
Ashino T, Yamamoto M, Numazawa S (2016) Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep 6:26291
Siasos G, Mourouzis K, Oikonomou E, Tsalamandris S, Tsigkou V, Vlasis K, Vavuranakis M, Zografos T, Dimitropoulos S, Papaioannou TG, Kalampogias A, Stefanadis C, Papavassiliou AG, Tousoulis D (2015) The role of Endothelial dysfunction in aortic aneurysms. Curr Pharm Des 21:4016–4034
Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840–844
Hofmann A, Brunssen C, Morawietz H (2017) Contribution of lectin-like oxidized low-density lipoprotein receptor‑1 and LOX‑1 modulating compounds to vascular diseases. Vascular Pharmacology S1537-1891(17)30171-4
Davis FM, Rateri DL, Daugherty A (2015) Abdominal aortic aneurysm: novel mechanisms and therapies. Curr Opin Cardiol 30:566–573
Sun J, Deng H, Zhou Z, Xiong X, Gao L (2018) Endothelium as a potential target for treatment of abdominal aortic aneurysm. Oxid Med Cell Longev 2018:6306542
Grote K, Flach I, Luchtefeld M, Akin E, Holland SM, Drexler H, Schieffer B (2003) Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase‑2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species. Circ Res 92:e80–e86
Shin MH, Moon YJ, Seo JE, Lee Y, Kim KH, Chung JH (2008) Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP‑1 and MMP‑9 expression. Free Radic Biol Med 44:635–645
Chen Q, Wang Q, Zhu J, Xiao Q, Zhang L (2017) Reactive oxygen species: key regulators in vascular health and diseases. Br J Pharmacol 175(8):1279–1292
Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A, American Heart Association Council on Basic Cardiovascular S. (2016) Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American Heart Association. Circ Res 119:e39–e75
Brown DI, Griendling KK (2015) Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circ Res 116:531–549
Drummond GR, Sobey CG (2014) Endothelial NADPH oxidases: which NOX to target in vascular disease? Trends Endocrinol Metab 25:452–463
Miller FJ Jr., Sharp WJ, Fang X, Oberley LW, Oberley TD, Weintraub NL (2002) Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. arterioscler Thromb Vasc Biol 22:560–565
Emeto TI, Moxon JV, Au M, Golledge J (2016) Oxidative stress and abdominal aortic aneurysm: potential treatment targets. Clin Sci 130:301–315
Guzik B, Sagan A, Ludew D, Mrowiecki W, Chwala M, Bujak-Gizycka B, Filip G, Grudzien G, Kapelak B, Zmudka K, Mrowiecki T, Sadowski J, Korbut R, Guzik TJ (2013) Mechanisms of oxidative stress in human aortic aneurysms—association with clinical risk factors for atherosclerosis and disease severity. Int J Cardiol 168:2389–2396
McCormick ML, Gavrila D, Weintraub NL (2007) Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 27:461–469
Rivera J, Sobey CG, Walduck AK, Drummond GR (2010) Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. redox Rep 15:50–63
Murdoch CE, Alom-Ruiz SP, Wang M, Zhang M, Walker S, Yu B, Brewer A, Shah AM (2011) Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol 106:527–538
Lassegue B, Griendling KK (2010) NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol 30:653–661
Jung O, Schreiber JG, Geiger H, Pedrazzini T, Busse R, Brandes RP (2004) gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation 109:1795–1801
Schurmann C, Rezende F, Kruse C, Yasar Y, Lowe O, Fork C, van de Sluis B, Bremer R, Weissmann N, Shah AM, Jo H, Brandes RP, Schroder K (2015) The NADPH oxidase Nox4 has anti-atherosclerotic functions. Eur Heart J 36:3447–3456
Langbein H, Brunssen C, Hofmann A, Cimalla P, Brux M, Bornstein SR, Deussen A, Koch E, Morawietz H (2016) NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice. Eur Heart J 37:1753–1761
Sies H (2017) Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress. Redox Biol 11:613–619
Wang Y, Krishna S, Walker PJ, Norman P, Golledge J (2013) Transforming growth factor-beta and abdominal aortic aneurysms. Cardiovasc Pathol 22:126–132
Guzik TJ, Sadowski J, Kapelak B, Jopek A, Rudzinski P, Pillai R, Korbut R, Channon KM (2004) Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins. Arterioscler Thromb Vasc Biol 24:1614–1620
Kigawa Y, Miyazaki T, Lei XF, Nakamachi T, Oguchi T, Kim-Kaneyama JR, Taniyama M, Tsunawaki S, Shioda S, Miyazaki A (2014) NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol 34:2413–2420
Siu KL, Li Q, Zhang Y, Guo J, Youn JY, Du J, Cai H (2017) NOX isoforms in the development of abdominal aortic aneurysm. Redox Biol 11:118–125
Lu WW, Jia LX, Ni XQ, Zhao L, Chang JR, Zhang JS, Hou YL, Zhu Y, Guan YF, Yu YR, Du J, Tang CS, Qi YF (2016) Intermedin1-53 attenuates abdominal aortic aneurysm by inhibiting oxidative stress. arterioscler Thromb Vasc Biol 36:2176–2190
Jimenez-Altayo F, Meirelles T, Crosas-Molist E, Sorolla MA, Del Blanco DG, Lopez-Luque J, Mas-Stachurska A, Siegert AM, Bonorino F, Barbera L, Garcia C, Condom E, Sitges M, Rodriguez-Pascual F, Laurindo F, Schroder K, Ros J, Fabregat I, Egea G (2018) Redox stress in Marfan syndrome: dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm. Free Radic Biol Med 118:44–58
Gavazzi G, Deffert C, Trocme C, Schappi M, Herrmann FR, Krause KH (2007) NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension 50:189–196
Sies H, Berndt C, Jones DP (2017) Oxidative stress. Annu Rev Biochem 86:715–748
Alfieri A, Srivastava S, Siow RC, Modo M, Fraser PA, Mann GE (2011) Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke. J Physiol 589:4125–4136
Tomczyk M, Kraszewska I, Dulak J, Jazwa-Kusior A (2019) Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase‑1. Vasc Pharmacol 112:79–90
Calay D, Mason JC (2014) The multifunctional role and therapeutic potential of HO‑1 in the vascular endothelium. Antioxidants & Redox Signaling 20:1789–1809
Kaneda H, Ohno M, Taguchi J, Togo M, Hashimoto H, Ogasawara K, Aizawa T, Ishizaka N, Nagai R (2002) Heme oxygenase‑1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Arterioscler Thromb Vasc Biol 22:1680–1685
Otterbein LE, Foresti R, Motterlini R (2016) Heme Oxygenase‑1 and carbon monoxide in the heart: the balancing act between danger signaling and pro-survival. circ Res 118:1940–1959
Ishikawa K, Sugawara D, Goto J, Watanabe Y, Kawamura K, Shiomi M, Itabe H, Maruyama Y (2001) Heme oxygenase‑1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits. Circulation 104:1831–1836
Ishikawa K, Sugawara D, Wang X, Suzuki K, Itabe H, Maruyama Y, Lusis AJ (2001) Heme oxygenase‑1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ Res 88:506–512
Nakayama M, Takahashi K, Komaru T, Fukuchi M, Shioiri H, Sato K, Kitamuro T, Shirato K, Yamaguchi T, Suematsu M, Shibahara S (2001) Increased expression of heme oxygenase‑1 and bilirubin accumulation in foam cells of rabbit atherosclerotic lesions. Arterioscler Thromb Vasc Biol 21:1373–1377
Wang LJ, Lee TS, Lee FY, Pai RC, Chau LY (1998) Expression of heme oxygenase‑1 in atherosclerotic lesions. Am J Pathol 152:711–720
Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ, Araujo JA (2007) Heme oxygenase‑1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res 100:1703–1711
Schillinger M, Exner M, Mlekusch W, Domanovits H, Huber K, Mannhalter C, Wagner O, Minar E (2002) Heme oxygenase‑1 gene promoter polymorphism is associated with abdominal aortic aneurysm. Thromb Res 106:131–136
Ho YC, Wu ML, Gung PY, Chen CH, Kuo CC, Yet SF (2016) Heme oxygenase‑1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice. Oncotarget 7:67760–67776
Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, Ghezzi P, Leon R, Lopez MG, Oliva B, Pajares M, Rojo AI, Robledinos-Anton N, Valverde AM, Guney E, Schmidt H (2018) Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach. Pharmacol Rev 70:348–383
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A. Hofmann, S. Wolk, M. Müglich, S. Tietze und C. Reeps geben an, dass kein Interessenkonflikt besteht.
Alle beschriebenen Untersuchungen am Menschen (Abbildung 1a, Abbildung 1b) wurden mit Zustimmung der zuständigen Ethik-Kommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.
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Hofmann, A., Wolk, S., Müglich, M. et al. Oxidative und antioxidative Prozesse in abdominellen Aortenaneurysmen. Gefässchirurgie 25, 124–128 (2020). https://doi.org/10.1007/s00772-020-00614-7
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DOI: https://doi.org/10.1007/s00772-020-00614-7