Skip to main content

Advertisement

SpringerLink
Log in

Toll-like-Rezeptor 2/6 Signaling bei vaskulärer Regeneration und Adaptation

Toll-like receptor 2/6 signaling in vascular regeneration and adaptation

  • Netzwerk Grundlagenforschung
  • Published:
Gefässchirurgie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Anderson KV, Jürgens G, Nüsslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42:779–789

    Article  CAS  PubMed  Google Scholar 

  2. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394–397

    Article  CAS  PubMed  Google Scholar 

  3. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085–2088

    Article  CAS  PubMed  Google Scholar 

  4. O’Neill LA, Golenbock D, Bowie AG (2013) The history of Toll-like receptors—redefining innate immunity. Nat Rev Immunol 13:453–460

    Article  CAS  PubMed  Google Scholar 

  5. Seki E, Brenner DA (2008) Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 48:322–335

    Article  CAS  PubMed  Google Scholar 

  6. Falck-Hansen M, Kassiteridi C, Monaco C (2013) Toll-like receptors in atherosclerosis. Int J Mol Sci 14:14008–14023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. de Groot D, Hoefer IE, Grundmann S, Schoneveld A, Haverslag RT, van Keulen JK, Bot PT, Timmers L, Piek JJ, Pasterkamp G, de Kleijn DP (2011) Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. J Mol Cell Cardiol 50:25–32

    Article  CAS  PubMed  Google Scholar 

  8. Gibson FC, Hong C, Chou H‑H, Yumoto H, Chen J, Lien E, Wong J, Attardo Genco C (2004) Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E‑deficient mice. Circulation 109:2801–2806

    Article  CAS  PubMed  Google Scholar 

  9. Mühlradt PF, Kiess M, Meyer H, Süssmuth R, Jung G (1997) Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med 185:1951–1958

    Article  PubMed  Google Scholar 

  10. Grote K, Schuett H, Salguero G, Grothusen C, Jagielska J, Drexler H, Mühlradt PF, Schieffer B (2010) Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration. Blood 115:2543–2552

    Article  CAS  PubMed  Google Scholar 

  11. Grote K, Sonnenschein K, Kapopara PR, Hillmer A, Grothusen C, Salguero G, Kotlarz D, Schuett H, Bavendiek U, Schieffer B (2013) Toll-like receptor 2/6 agonist macrophage-activating lipopeptide-2 promotes reendothelialization and inhibits neointima formation after vascular injury. Arterioscler Thromb Vasc Biol 33:2097–2104

    Article  CAS  PubMed  Google Scholar 

  12. Grote K, Petri M, Liu C, Jehn P, Spalthoff S, Kokemüller H, Luchtefeld M, Tschernig T, Krettek C, Haasper C, Jagodzinski M (2013) Toll-like receptor 2/6-dependent stimulation of mesenchymal stem cells promotes angiogenesis by paracrine factors. Eur Cell Mater 11:66–79

    Article  Google Scholar 

  13. Curtiss LK, Black AS, Bonnet DJ, Tobias PS (2012) Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists. J Lipid Res 53:2126–2132

    Article  CAS  PubMed  Google Scholar 

  14. Cho ML, Ju JH, Kim HR, Oh HJ, Kang CM, Jhun JY, Lee SY, Park MK, Min JK, Park SH, Lee SH, Kim HY (2007) Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunol Lett 108:121–128

    Article  CAS  PubMed  Google Scholar 

  15. Wang W, Xu GL, Jia WD, Ma JL, Li JS, Ge YS, Ren WH, Yu JH, Liu WB (2009) Ligation of TLR2 by versican: a link between inflammation and metastasis. Arch Med Res 40:321–323

    Article  CAS  PubMed  Google Scholar 

  16. West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, Borden EC, Podrez EA, Salomon RG, Byzova TV (2010) Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467:972–976

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kardiologie und Angiologie, Philipps-Universität Marburg, Hans-Meerwein-Straße 2, 35043, Marburg, Deutschland

    K. Grote

Authors
  1. K. Grote
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Grote.

Ethics declarations

Interessenkonflikt

K. Grote gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren neu durchgeführten Studien an Menschen oder Tieren. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Bei den veröffentlichten eigenen Arbeiten wurden alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren eingehalten und die notwendigen Zustimmungen der zuständigen Behörden liegen vor.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grote, K. Toll-like-Rezeptor 2/6 Signaling bei vaskulärer Regeneration und Adaptation. Gefässchirurgie 24, 422–424 (2019). https://doi.org/10.1007/s00772-019-0544-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00772-019-0544-7

Search

Navigation