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Review of bleomycin, ethanol and sodium tetradecyl sulfate as sclerosant agents in vascular malformations

Vergleich von Bleomycin, Ethanol und Natriumtetradecylsulfat als sklerosierende Wirkstoffe bei vaskulären Malformationen

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Abstract

Purpose

The aim of this article is to review the published literature on the use of bleomycin, ethanol and sodium tetradecyl sulfate as sclerosing embolic agents in vascular malformation management and contrast and compare them.

Material and methods

Published journal articles on bleomycin, ethanol and sodium tetradecyl sulfate employed in vascular malformation management were reviewed and the results were analyzed.

Results

While efficacy has been described for all the sclerosing embolic agents, absolute ethanol appears to be superior compared to others in that cures were routinely documented.

Conclusion

Absolute ethanol is highly effective in the permanent eradication and permanent ablation of high-flow and low-flow vascular malformations.

Zusammenfassung

Zweck

Das Ziel dieses Beitrags ist es, die publizierte Literatur zur Anwendung von Bleomycin, Ethanol und Natriumtetradecylsulfat als sklerosierende Wirkstoffe zur Behandlung vaskulärer Malformationen gegenüberzustellen und zu vergleichen.

Material und Methoden

Es wurden die Ergebnisse publizierter Beiträge zu Bleomycin, Ethanol und Natriumtetradecylsulfat zur Behandlung vaskulärer Malformationen analysiert.

Ergebnisse

Während die Wirksamkeit für alle sklerosierenden Embolisationswirkstoffe beschrieben wurde, scheint reines Ethanol im Vergleich zu anderen Wirkstoffen überlegen zu sein.

Schlussfolgerung

Reines Ethanol ist hochwirksam für die langfristige Eradikation und permanente Ablation von High-flow- und Low-flow-Gefäßmalformationen.

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Authors and Affiliations

  1. Klinik und Poliklinik für Gefäßmedizin, Universitäres Herzzentrum Hamburg, Klinik und Poliklinik für Gefäßmedizin, Universitätsklinikum Hamburg-Eppendorf, 20246, Hamburg, Germany

    F. Rohlffs

  2. The Yakes Vascular Malformation Center, Englewood, CO, USA

    W. F. Yakes

Authors
  1. F. Rohlffs
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  2. W. F. Yakes
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Corresponding author

Correspondence to F. Rohlffs.

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Conflict of interest

F. E. V. Rohlffs and W. F. J. Yakes declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Rohlffs, F., Yakes, W.F. Review of bleomycin, ethanol and sodium tetradecyl sulfate as sclerosant agents in vascular malformations. Gefässchirurgie 23, 502–506 (2018). https://doi.org/10.1007/s00772-018-0461-1

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  • DOI: https://doi.org/10.1007/s00772-018-0461-1

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