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Mausmodelle der tiefen Venenthrombose

Mouse models of deep vein thrombosis

  • Translationale Forschung
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Gefässchirurgie Aims and scope Submit manuscript

Zusammenfassung

Noch immer ist die Pathogenese des venösen Thromboembolismus (VTE) nicht bis ins Detail geklärt. Experimentaltiere, in denen eine tiefe Venenthrombose generiert wird, sind hilfreich bei der Erforschung der VTE-Pathogenese. Neben der Verfügbarkeit von transgenen bzw. genetisch modifizierten Mäusen spielt die Verwendung von Hochfrequenzultraschall und Intravitalmikroskopie bei der Darstellung thrombotischer Prozesse im Mausmodell eine große Rolle. Der Beitrag gibt einen Überblick über die Verwendung neuer Technologien sowie über bestehende Modelle und stellt den Einfluss von venösen Seitenästen auf die tiefe Venenthrombose im Mausmodell dar.

Abstract

The pathogenesis of venous thromboembolism (VTE) is still not completely understood. Experimental animals in which human deep vein thrombosis can be modeled are useful tools to investigate the pathogenesis of VTE. Besides the availability of transgenic and genetically modified mice, the use of high frequency ultrasound and intravital microscopy plays an important role in identifying thrombotic processes in mouse models. In this article, an overview about the application of various new technologies and existing mouse models is provided, and the impact of venous side branches on deep vein thrombosis in the mouse model is discussed.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. P. Wenzel, T. Schönfelder und S. Jäckel geben an, dass kein Interessenkonflikt besteht. Alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren wurden eingehalten. Die notwendigen Zustimmungen der zuständigen Behörden liegen vor.

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Authors and Affiliations

  1. Centrum für Thrombose und Hämostase, Universitätsmedizin Mainz, Mainz, Deutschland

    T. Schönfelder, S. Jäckel &  P. Wenzel

  2. 2. Medizinische Klinik, Universitätsmedizin, Johannes-Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland

    P. Wenzel

Authors
  1. T. Schönfelder
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  2. S. Jäckel
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  3. P. Wenzel
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Corresponding author

Correspondence to P. Wenzel.

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The English full-text version of this article is available at SpringerLink (under „Supplemental“).

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Schönfelder, T., Jäckel, S. & Wenzel, P. Mausmodelle der tiefen Venenthrombose. Gefässchirurgie 19, 257–262 (2014). https://doi.org/10.1007/s00772-013-1277-7

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  • DOI: https://doi.org/10.1007/s00772-013-1277-7

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