Skip to main content
SpringerLink
Log in

Das biologische Verhalten von Homografts zum arteriellen Gefäßersatz

The biological behavior of homografts for arterial replacement

  • Leitthema
  • Published:
Gefässchirurgie Aims and scope Submit manuscript

Zusammenfassung

Wenn geeignetes autologes Venenmaterial zur peripheren arteriellen Revaskularisation fehlt, kann der Einsatz von Homografts erwogen werden. Die aktuelle Literatur sowie eigene Erfahrungen werden anhand des Gefäßmaterials, der Konservierungsmethode, der Antikoagulation sowie einer eventuell erforderlichen Immunsuppression dargestellt.

Abstract

In cases where suitable autologous veins for peripheral arterial reconstruction are lacking, the use of homografts can be considered. The current literature as well as the authors own experience are presented according to the vessel material, the method of conservation, the anticoagulation and the necessity for immunosuppression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Aalders GJ, Vroonhoven TJ van (1992) Polytetrafluoroethylene versus human umbilical vein in above-knee femoropopliteal bypass: six-year results of a randomized clinical trial. J Vasc Surg 16:816–823

    Article  CAS  PubMed  Google Scholar 

  2. Albertini JN, Barral X, Branchereau A et al (2000) Long-term results of arterial allograft below-knee bypass grafts for limb salvage: a retrospective multicenter study. J Vasc Surg 31:426–435

    Article  CAS  PubMed  Google Scholar 

  3. Ali AT, Modrall JG, Hocking J et al (2009) Long-term results of the treatment of aortic graft infection by in situ replacement with femoral popliteal vein grafts. J Vasc Surg 50:30–39

    Article  PubMed  Google Scholar 

  4. Bahnini A, Ruotolo C, Koskas F, Kieffer E (1991) In situ fresh allograft replacement of an infected aortic prosthetic graft: eighteen months‘ follow-up. J Vasc Surg 14:98–102

    Article  CAS  PubMed  Google Scholar 

  5. Balzer KM, Luther B, Sandmann W, Wassmuth R (2004) Donor-specific sensitization by cadaveric venous allografts used for arterial reconstruction in peripheral arterial occlusive vascular disease. Tissue Antigens 64(1):13–17

    Article  CAS  PubMed  Google Scholar 

  6. Bannazadeh M, Sarac TP, Bena J et al (2009) Reoperative lower extremity revascularization with cadaver vein for limb salvage. Ann Vasc Surg 23:24–31

    Article  PubMed  Google Scholar 

  7. Bellon JM, Gimeno MY, Pascual GI, Garcia-Honduvilla N (1999) Arterial damage induced by cyropreservation is irreversible following organ culture. Eur J Vasc Surg 17:136–143

    Article  CAS  Google Scholar 

  8. Buckley CJ, Abernathy S, Lee SD et al (2000) Suggested treatment protocol for improving patency of femoral-infrapopliteal crypreserved saphenous vein allografts. J Vasc Surg 32:731–738

    Article  CAS  PubMed  Google Scholar 

  9. Cacciatore R, Inderbitzi R, Stirnemann P (1992) Five years experience with infra-inguinal arterial reconstruction: a comparison of venous with PTFE bypass. VASA 21(2):171–176

    CAS  PubMed  Google Scholar 

  10. Carpenter JP, Tomaszewski JE (1997) Immunosuppression for human saphenous vein allograft bypass surgery: a prospective randomized trial. J Vasc Surg 26:32–42

    Article  CAS  PubMed  Google Scholar 

  11. Carrel A (1908) Results of the transplantation of blood vessels, organs and limbs. JAMA 51:1662

    Google Scholar 

  12. Castier Y, Francis F, Cerceau P et al (2005) Cryopreserved arterial allograft reconstruction for peripheral graft infection. J Vasc Surg 41:30–37

    Article  PubMed  Google Scholar 

  13. Castier Y, Lesèche G, Palombi T et al (1999) Early experience with cryopreserved arterial allografts in below-knee revascularization for limb salvage. Am J Surg 177:197–202

    Article  CAS  PubMed  Google Scholar 

  14. Dye WS, Julian OC (1956) Two to four years behavior of vein grafts in the lower extremities. Arch Surg 72:64–68

    CAS  Google Scholar 

  15. Ellis P, Müller-Schweinitzer E (1991) Maintenance of functional activity of human pulmonary arteries after cryopreservation. Br J Pharmacol 103:1377–1380

    CAS  PubMed  Google Scholar 

  16. Evans LE, Webster MW, Brooks DH, Bahnson HT (1981) Expanded polytetrafluoroethylene femoropopliteal grafts: forty-eight- month follow-up. Surgery 89(1):16–22

    CAS  PubMed  Google Scholar 

  17. Fahner PJ, Idu MM, Gulik TM van, Legemate DA (2006) Systematic review of preservation methods and clinical outcome of infrainguinal vascular allografts. J Casc Surg 44:518–524

    Article  Google Scholar 

  18. Farber A, Major K, Wagner WH et al (2003) Cryopreserved saphenous vein allografts in infrainguinal revascularization: analysis of 240 grafts. J Vasc Surg 38:15–21

    Article  PubMed  Google Scholar 

  19. Galambos B, Csönge L, Olah A et al (2005) Preservation of fresh vein homografts viability during long-term storage. Eur Surg Res 37:60–66

    Article  CAS  PubMed  Google Scholar 

  20. Galambos B, Oláh A, Banga P et al (2009) Successful human vascular reconstruction with long-term refrigerated venous homografts. Eur Surg Res 43:256–261

    Article  PubMed  Google Scholar 

  21. Gournier JP, Favre JP, Gay JL, Barral X (1995) Cryopreserved arterial allografts for limb salvage in the absence of suitable saphenous vein: two-year results in 20 cases. Ann Vasc Surg 9(Suppl):S7–S14

    Article  PubMed  Google Scholar 

  22. Guthrie CC (1908) Structural changes and survival of cells in transplanted blood vessels. JAMA 50:1035–1036

    Google Scholar 

  23. Harris L, O‚Brien-Irr M, Ricotta JJ (2001) Long-term assessment of cryopreserved vein bypass grafting success. J Vasc Surg 33:528–532

    Article  CAS  PubMed  Google Scholar 

  24. Harris RW, Schneider PA, Andros G et al (1993) Allograft vein bypass: is it an acceptable alternative for infrapopliteal revascularization? J Vasc Surg 18:553–559

    Article  CAS  PubMed  Google Scholar 

  25. Kieffer E, Gomes D, Chiche L et al (2004) Allograft replacement for infrarenal aortic graft infection: early and late results in 170 patients. J Vasc Surg 39:1009–1017

    Article  PubMed  Google Scholar 

  26. Linton RR (1955) Some practical considerations in the surgery of blood vessel grafts. Surgery 38:817–834

    CAS  PubMed  Google Scholar 

  27. Litvan GG (1972) Mechanism of cryoinjury in biological systems. Cryobiology 9:182–191

    Article  CAS  PubMed  Google Scholar 

  28. Lopez-Cepero M, Sanders CE, Buggs J, Bowers V (2002) Sensitization of renal transplant candidates by cryopreserved cadaveric venous or arterial allografts. Transplantation 73:817–819

    Article  PubMed  Google Scholar 

  29. Losi P, Lombardi S, Briganti E, Soldani G (2004) Luminal surface microgeometry affects platelet adhesion in small-diameter synthetic grafts. Biomaterials 25:4447-4455

    Article  CAS  PubMed  Google Scholar 

  30. Magne JL, Farah I, Roux JJ et al (1997) Below-knee bypass using fresh arterial allografts for limb salvage: early results. Ann Vasc Surg 11:237–241

    Article  CAS  PubMed  Google Scholar 

  31. Martin RS 3rd, Edwards WH, Mulherin JL Jr et al (1994) Cryopreserved saphenous vein allografts for below-knee lower extremity revascularization. Ann Surg 219:664–672

    Article  PubMed  Google Scholar 

  32. McAuley CE, Steed DL, Webster MW (1984) Seven-year follow-up of expanded polytetrafluoroethylene (PTFE) femoropopliteal bypass grafts. Ann Surg 199(1):57–60

    Article  CAS  PubMed  Google Scholar 

  33. Ochsner JL, Lawson JD, Eskind JD et al (1984) Homologous veins as an arterial substitute: Long-term results. J Vasc Surg 1:306–313

    Article  CAS  PubMed  Google Scholar 

  34. Perloff LJ, Reckard C1, Rowlands DT, Barker CF (1972) The venous homograft: an immunological question. Surgery 72:961–970

    CAS  PubMed  Google Scholar 

  35. Prager M, Hölzenbein T, Aslim E et al (2002) Fresh arterial homograft transplantation: a novel concept for critical limb ischaemia. Eur J Vasc Endovasc Surg 24:314–321

    Article  CAS  PubMed  Google Scholar 

  36. Prendiville EJ, Yeager A, O’Donnell TF Jr et al (1990) Long-term results with the above-knee popliteal expanded polytetrafluoroethylene graft. J Vasc Surg 11(4):517–524

    Article  CAS  PubMed  Google Scholar 

  37. Quinones-Baldrich WJ, Prego AA, Ucelay-Gomez R et al (1992) Long-term results of infrainguinal revascularization with polytetrafluoroethylene: a ten-year experience. J Vasc Surg 16(2):209–217

    Article  CAS  PubMed  Google Scholar 

  38. Sandmann W, Zumfelde L, Lenz W et al (1979) Die Behandlung von femoropoplitealen Rezidivverschlüssen mit homologer Vene. In: Wagner O, Kubiena K (Hrsg) Der Rezidivverschluss nach Gefäßrekonstruktion an der unteren Extremität. Egermann, Wien, S 157–161

  39. Schoeffter P, Müller-Schweinitzer E (1990) The preservation of functional activity of smooth muscle and endothelium in pig coronary arteries after storage at –190°C. J Pharm Pharmacol 42:646–651

    CAS  PubMed  Google Scholar 

  40. Streinchenberger R, Barjoud H, Adeleine P et al (2000) Venous allografts preserved at 4 degrees C for infrainguinal bypass: long-term results from 170 procedures. Ann Vasc Surg 14:553–560

    Article  CAS  PubMed  Google Scholar 

  41. The Dutch Bypass Oral anticoagulants or aspirin (BOA) Study group (2000) Efficacy of oral anticoagulants compared with aspirin after infrainguinal bypass surgery (the Dutch Bypass Oral anticoagulants or Aspirin study): a randomised trial. Lancet 355:346–351

    Article  Google Scholar 

  42. Veith FJ, Gupta SK, Ascer E et al (1986) Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions. J Vasc Surg 3(1):104–114

    Article  CAS  PubMed  Google Scholar 

  43. Walker PJ, Mitchell RS, Mc Fadden PM et al (1993) Early experiences with cryopreserved saphenous vein allografts as a conduit for complex limb salvage procedures. J Vasc Surg 18:561–568

    Article  CAS  PubMed  Google Scholar 

  44. Weisel RD, Johnson KW, Baird RJ et al (1981) Comparison of conduits for leg revascularization. Surgery 89:8–15

    CAS  PubMed  Google Scholar 

Download references

Danksagung

Der korrespondierende Autor K.M. Balzer möchte Herrn em.-Prof. Dr. med. Dr. h.c. Wilhelm Sandmann für die exzellente chirurgische, klinische und wissenschaftliche Ausbildung danken.

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Klinik für Gefäßchirurgie und Nierentransplantation, Universitätsklinik Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    K.M. Balzer & W. Sandmann

Authors
  1. K.M. Balzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Sandmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K.M. Balzer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Balzer, K., Sandmann, W. Das biologische Verhalten von Homografts zum arteriellen Gefäßersatz. Gefässchirurgie 15, 101–107 (2010). https://doi.org/10.1007/s00772-009-0729-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00772-009-0729-6

Schlüsselwörter

Keywords

Search

Navigation