Zusammenfassung
Design und Planung eines klinischen Forschungsprojekts bestimmen dessen wissenschaftliche Qualität. Statistische Methoden in Kombination mit Konzepten der klinischen Epidemiologie liefern hierzu wesentliche Beiträge. Regeln zur Darstellung relevanter Informationen bestimmen ebenso die wissenschaftliche Qualität der Veröffentlichung. Diese Regeln werden oft übersehen. Autoren, Editoren, Reviewer und Leser sind sich oft nicht im Klaren, welche wichtigen Informationen kommuniziert werden müssen. Das schlechte Berichten von Ergebnissen schadet unweigerlich anderen Forschern, der klinischen Praxis und letztendlich den Patienten. Eine gute Ergebnisdarstellung macht Evidenz nutzbar. Design und Reporting sind zwei Seiten der gleichen Münze. Die Kenntnis ihrer Grundprinzipien lässt den Leser bewusster die Qualität einer Veröffentlichung bewerten.
Abstract
At one hand, scientific quality of a clinical research project is determined by its design and planning process. Hereunto, statistical methods and concepts of clinical epidemiology give essential input. On the other hand, reporting guidelines provide advice on how to report research methods and findings and are equally relevant to assure the perceived scientific quality. They are mostly ignored by authors, editors, reviewers, and readers. Bad reporting undermines the usability of reported findings and misleads clinicians, researchers, policymakers and, ultimately, patients. A good practice of reporting produces ready to use evidence. It relies on statistical methods and concepts of clinical epidemiology. Results of statistical analyses will be presented to be used in new analyses and simulations which feed systematic reviews or clinical decision models. Therefore, reporting is not only the presentation of a story which is finished. It is also a tool to change the future.
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Mansmann, U. Design und Reporting klinischer Forschung. Gefässchirurgie 14, 329–337 (2009). https://doi.org/10.1007/s00772-009-0701-5
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DOI: https://doi.org/10.1007/s00772-009-0701-5