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Wirkung niederfrequent gepulster Magnetfelder auf die Mikrozirkulation bei pAVK-Patienten

Randomisierte, placebokontrollierte Einfachblindstudie

Effect of low-frequency pulsating magnetic fields on microcirculation in PAOD patients

A randomized placebo-controlled single-blind trial

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Zusammenfassung

Zur Untersuchung möglicher durchblutungsfördernder Effekte niederfrequent gepulster schwacher Magnetfelder, die bei gestörter Frakturheilung seit Jahrzehnten erfolgreich eingesetzt werden, wurde im placebokontrollierten Experiment bei pAVK-Patienten der Stadien IIb bis IV ein mit 4 Hz gepulstes Magnetfeld mit einer Intensität von 5 μT über eine Ganzkörper-Magnetfeldmatte appliziert. Nachweisen ließ sich in der Verumgruppe (n=30) unter einmaliger einstündiger Anwendung eine signifikante Steigerung des Laser-Doppler-Fluxes um über 50% und des tcpO2 um 17% (Messung am Fußrücken), wobei der Anstieg der Werte umso größer ist, je niedriger die Ausgangswerte sind. Für Puls und Blutdruck sowie cAMP und cGMP (im Venenblut) ließen sich keine Veränderungen feststellen. Es wurden keinerlei unerwünschte Wirkungen beobachtet.

Unter Berücksichtigung bestehender Erklärungsansätze für die Wirkung niederfrequent gepulster Magnetfelder auf den Organismus wird ein Modell entwickelt, das die Vielzahl bekannter Magnetfeldeffekte bei gleichzeitiger Nebenwirkungsfreiheit zurückführt auf die Interaktion des Magnetfeldes mit physiologischen Regulationsprozessen auf der Basis endogener elektromagnetischer Phänomene.

Abstract

To investigate possible beneficial effects on circulation of low-intensity low-frequency pulsating magnetic fields, a 5-µT magnetic field pulsed at 4 Hz was applied to PAOD patients stage IIb-IV in a placebo-controlled study design using a total body applicator. During a single 1-h treatment session in the active treatment group (n=30) there was an increase in laser Doppler flux of more than 50% and in tcpO2 of 17% (foot dorsum) whereas patients with low baseline values achieved the highest increases. No differences were found for pulse, blood pressure, cAMP, or cGMP (venous blood analysis). No adverse effects were noted.

With respect to preexisting explanations of magnetic field effects on living organisms, a theory was evolved that attributes the great variety of known effects in the absence of adverse side effects to the interaction of the magnetic field with physiologically existing regulative processes based on endogenous electromagnetic phenomena.

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Authors and Affiliations

  1. Klinik für Chirurgie, Kantonsspital Obwalden, Sarnen, Schweiz

    M. Brestowsky

  2. International Institute of Biophysics, Neuss

    L. von Klitzing

  3. Klinik für Chirurgie des Universitätsklinikums Schleswig-Holstein, Campus Lübeck

    H.-P. Bruch

  4. Klinik für Chirurgie, Zollernalbkliniken gGmbH, Albstadt

    U. Markert

  5. Kantonsspital Obwalden, Brünigstr. 181, 6060, Sarnen, Schweiz

    M. Brestowsky

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  1. M. Brestowsky
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  2. L. von Klitzing
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  3. H.-P. Bruch
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  4. U. Markert
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Correspondence to M. Brestowsky.

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Brestowsky, M., von Klitzing, L., Bruch, HP. et al. Wirkung niederfrequent gepulster Magnetfelder auf die Mikrozirkulation bei pAVK-Patienten. Gefässchirurgie 9, 111–116 (2004). https://doi.org/10.1007/s00772-004-0337-4

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  • DOI: https://doi.org/10.1007/s00772-004-0337-4

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