Homogeneity and stability of reference materials
- Cite this article as:
- Linsinger, T., Pauwels, J., van der Veen, A. et al. Accred Qual Assur (2001) 6: 20. doi:10.1007/s007690000261
- 591 Downloads
Homogeneity and stability are two crucial characteristics of any certified reference material (CRM). Utmost care must be taken during preparation to create materials as homogeneous and stable as possible. Degradation can generally be minimised by reducing the water activity of the material to a level between 0.15 and 0.35. However, careful preparation by itself is not enough. Positive demonstration of homogeneity and stability is required from the perspective of implementing uncertainty calculus according to the Guide to the Expression of Uncertainty in Measurement (GUM). In many cases, homogeneity and stability studies fail to give sufficient quantitative information on homogeneity and stability, mainly because of a lack of measurement repeatability and insufficient number of replicates. In this work, some solutions to these problems and their implications are presented.