Good laboratory practice-compliant bio-efficacy testing of repellent products against Aedes aegypti


The Medical Entomology Unit of the Institute for Medical Research, Kuala Lumpur, is a laboratory that was certified in 2019 to conduct evaluation of vector control products in compliance to the Organisation for Economic Co-operation and Development principles of good laboratory practice (GLP) laboratory. To ensure the product evaluation practice complies with the GLP principles and corrections are made for improving test procedures, internal inspections by the Quality Assurance team play a crucial role. Before commencing GLP-compliant studies, study plans are developed according to the study objectives and critically examined to ensure they are performed in accordance with the GLP principles. We described the quality of test system, test item and test method used for evaluation of repellent effect of topically applied repellent products in accordance to the GLP test requirements.

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  1. Malaysian Standards (2007) Household Insecticide Products—Personal Mosquito Repellent—Evaluation Method for Biological Efficacy (First Revision). MS 1497:2007, 13

  2. OECD (1998) Series on principles of good laboratory practice and compliance monitoring no. 1: OECD principles of good laboratory practice (as revised in 1997). ENV/MC/CHEM (98)17

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Grateful thanks to the Director General of Health Malaysia, the Director of Institute for Medical Research, for permission to publish this paper. Special appreciation is extended to the WHO Department of Control of Neglected Tropical Disease for its support throughout our journey through the Malaysian GLP programme.

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Correspondence to R. Rosilawati.

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Rosilawati, R., Ruziyatul Aznieda, A., Roziah, A. et al. Good laboratory practice-compliant bio-efficacy testing of repellent products against Aedes aegypti. Accred Qual Assur 26, 23–26 (2021).

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  • Good laboratory practice
  • Repellency test
  • Mosquito
  • Aedes aegypti
  • Test item
  • Test system
  • Test method