Literatur
Carmel R (2008) How I treat cobalamin (vitamin B12) deficiency. Blood 112(6):2214–2221. https://doi.org/10.1182/blood-2008-03-040253
Langan RC, Goodbred AJ (2017) Vitamin B12 deficiency: recognition and management. Am Fam Physician 96(6):384–389
Jarquin Campos A, Risch L, Nydegger U, Wiesner J, Vazquez Van Dyck M, Renz H et al (2020) Diagnostic accuracy of holotranscobalamin, vitamin B12, Methylmalonic acid, and homocysteine in detecting B12 deficiency in a large, mixed patient population. Dis Markers. https://doi.org/10.1155/2020/7468506
Bjørke Monsen AL, Ueland PM (2003) Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. Am J Clin Nutr 78(1):7–21. https://doi.org/10.1093/ajcn/78.1.7
Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J (2018) Harrison’s Principles of Internal Medicine, 20. Aufl. Bd. 1, 2. McGraw-Hill,
Bensky MJ, Ayalon-Dangur I, Ayalon-Dangur R, Naamany E, Gafter-Gvili A, Koren G et al (2019) Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency. Drug Deliv Transl Res 9(3):625–630. https://doi.org/10.1007/s13346-018-00613-y
Chaudhuri BP, Ceyssens F, Celen S, Bormans G, Kraft M, Puers R (2019) In-vivo intradermal delivery of co-57 labeled vitamin B‑12, and subsequent comparison with standard subcutaneous administration(). Annu Int Conf IEEE Eng Med Biol Soc, S 1670–1673 https://doi.org/10.1109/embc.2019.8857543
Masucci L, Goeree R (2013) Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis. Ont Health Technol Assess Ser 13(24):1–24
Sezer RG, Akoğlu HA, Bozaykut A, Özdemir GN (2018) Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children. Hematology 23(9):653–657. https://doi.org/10.1080/10245332.2018.1456023
Tillemans MPH, Donders EMVJ, Verweij SL, Van der Hoeven RTM, Kalisvaart KJ (2014) Effect of administration route on the pharmacokinetics of cobalamin in elderly patients: a randomized controlled trial. Curr Ther Res Clin Exp 76:21–25. https://doi.org/10.1016/j.curtheres.2014.01.001
Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A et al (2005) Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004655.pub2
Tefferi A, Pruthi RK (1994) The biochemical basis of cobalamin deficiency. Mayo Clin Proc 69(2):181–186. https://doi.org/10.1016/s0025-6196(12)61046-5
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
J. Weller und W. Bethge geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Der Verlauf der Kasuistik und die Laborparameter sind bewusst leicht abgeändert worden, sodass eine Identifikation der/des betroffenen Patient*in nicht möglich ist.
The supplement containing this article is not sponsored by industry.
Additional information
Redaktion
M. Christopeit, Tübingen
Ch. Oing, Hamburg
K. Hoeffken, Jena
Rights and permissions
About this article
Cite this article
Weller, J.F., Bethge, W. 76/w mit subakuter Gangstörung und gelblicher Blässe. Onkologe 27 (Suppl 1), 18–26 (2021). https://doi.org/10.1007/s00761-021-00922-x
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00761-021-00922-x