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Behandlungsstrategien beim Oropharynxkarzinom

Treatment strategies for oropharyngeal carcinoma

  • Leitthema
  • Published:
Der Onkologe Aims and scope

Abstract

Hintergrund

Das Oropharynxkarzinom (OPSCC) stellt aufgrund seiner weltweiten Inzidenzzunahme und der Assoziation mit dem humanen Papillomavirus HPV-16, aber auch chronischem Tabak‑/Alkoholkonsum eine genetisch heterogene Tumorgruppe mit hoher prognostischer Diversität dar.

Ziel

Die Übersichtsarbeit versucht, die aktuelle Sicht der Therapie und Prävention des OPSCC in Hinblick auf die Assoziation mit HPV16 darzustellen.

Material und Methoden

Die Übersicht erfolgt auf der Basis der aktuellen relevanten Literatur sowie der derzeit laufenden Studien.

Ergebnisse und Diskussion

Das OPSCC stellt sich als sehr komplexe, genetisch heterogene und daher detailliert anzusehende Gruppe von Kopf-Hals-Tumoren dar. Die derzeit widersprüchliche Studienlage, die auf dem Boden retrospektiver Daten aktuelle TNM-Klassifikation („8th Edition“) und die abzuwartenden prospektiven Daten zur Therapiedeintensivierung ermahnen aktuell eher zu einer konservativen Therapiebetrachtung. Durch die aktuellen Impfempfehlungen ist jetzt auch die HPV-Impfung für Jungen analog zu den Mädchen in Deutschland zugelassen.

Abstract

Background

Oropharyngeal squamous cell carcinoma (OPSCC) is a genetically heterogeneous group of tumors with high prognostic diversity due to the worldwide increase in incidence and the association with the human papillomavirus HPV-16 and also chronic tobacco and alcohol consumption.

Objective

The review presents the current view on treatment and prevention of OPSCC with respect to the association with HPV16.

Material and methods

This overview is based on the relevant available literature as well as currently running studies.

Results and discussion

The OPSCC is manifested as a very complex, genetically heterogeneous group of head and neck tumors, which should therefore be considered in detail. The currently contradictory study situation, the current TNM classification (8th edition) on the basis of retrospective data and the expected prospective patient data on the deintensification of treatment are currently more likely to encourage conservative treatment. Due to the current recommendations, the HPV vaccination for boys is now also approved in Germany analogously to girls.

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  1. HNO-Universitätsklinik Leipzig, Liebigstr. 10–14, 04103, Leipzig, Deutschland

    Andreas Dietz

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A. Dietz gibt folgende Interessenkonflikte an: Honorar für wissenschaftliche Vorträge und beratende Gremien: Merck Serono, Roche, Astra Zeneca, MSD, BMS, Sanofi; Forschungsförderung: Roche, Merck Serono, MSD.

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An der Erstellung des Manuskripts waren Frau Prof. Dr. Susanne Wiegand und Herr Dr. Gunnar Wichmann, HNO-Universitätsklinik Leipzig, beteiligt.

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Dietz, A. Behandlungsstrategien beim Oropharynxkarzinom. Onkologe 25, 210–223 (2019). https://doi.org/10.1007/s00761-018-0514-9

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