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Epidemiologie akuter Leukämien in Deutschland

Epidemiology of acute leukemia in Germany

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Zusammenfassung

Der Beitrag gibt einen Überblick über die Epidemiologie akuter Leukämien in Deutschland, basierend auf den Daten aus 8 deutschen epidemiologischen Krebsregistern und dem deutschen Kinderkrebsregister. Von den gut 1000 jährlichen Neuerkrankungen an akuter lymphatischer Leukämie (ALL) betreffen etwa 45 % Kinder unter 15 Jahren, während die jährlich rund 4100 Erkrankungen an akuter myeloischer Leukämie (AML) vor allem im höheren Lebensalter auftreten; das mediane Erkrankungsalter liegt bei 72 Jahren. In den letzten 10 Jahren zeigten sich insgesamt keine wesentlichen Veränderungen der Inzidenzraten. Die Fünfjahresüberlebenswahrscheinlichkeiten liegen im Kindesalter bei etwa 92 % (ALL) bzw. 74 % (AML), gehen aber mit steigendem Diagnosealter deutlich zurück. Die altersstandardisierten Inzidenzraten für Deutschland sind mit Ergebnissen aus Europa, den USA und Australien vergleichbar, während die entsprechenden Überlebenswahrscheinlichkeiten innerhalb Europas im oberen Bereich und auch höher als in den USA liegen.

Abstract

We present an overview of the epidemiology of acute leukemia in Germany, based on the data from eight German population-based cancer registries and the German childhood cancer registry. Of the more than 1000 annual cases of acute lymphoblastic leukemia (ALL) in Germany, about 45% of the children are below the age of 15 years, while 4100 annual cases of acute myeloid leukemia (AML) mostly occur in higher age groups, with a median age of 72 years at onset. During the last decade, the incidence rates have remained stable. The 5‑year survival is high for children (92% for ALL and 74% for AML) but survival decreases significantly with increasing age at onset. Age-standardized incidence rates are comparable to those reported for Europe, the USA, and Australia, while survival in Germany seems to be relatively high within Europe and also higher compared to the USA.

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Correspondence to Klaus Kraywinkel.

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K. Kraywinkel und C. Spix geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Kraywinkel, K., Spix, C. Epidemiologie akuter Leukämien in Deutschland. Onkologe 23, 499–503 (2017). https://doi.org/10.1007/s00761-017-0249-z

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  • DOI: https://doi.org/10.1007/s00761-017-0249-z

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