Skip to main content
SpringerLink
Log in

Pathomorphologie von Knochensarkomen

Pathomorphology of bone sarcoma

  • Leitthema
  • Published:
Der Onkologe Aims and scope

Zusammenfassung

Hintergrund

Knochensarkome sind seltene Erkrankungen mit Häufigkeitsgipfeln im Kindes- und jungen Erwachsenenalter bzw. höheren Erwachsenenalter.

Schlussfolgerung

Die Diagnostik dieser Tumoren basiert auf einer interdisziplinären Beurteilung unter Einbeziehung klinischer, radiologischer und pathomorphologischer Kriterien. Aufgrund der Seltenheit der Tumoren und teilweise schwierigen differenzialdiagnostischen Abgrenzung empfiehlt sich eine Untersuchung in einem auf Knochentumoren spezialisierten Zentrum.

Abstract

Background

Sarcomas of the bone are rare entities with a first peak of incidence during childhood and adolescence and a second peak in old age.

Conclusion

Diagnostic evaluation of these tumors is based on correlation of clinical, radiological and pathomorphological findings. Due to the rareness of these tumors and the difficult differential diagnosis, evaluation in specialized centers is highly recommended.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Dahlin DC (1978) Bone tumors. 3. Aufl. Thomas, Springfield

  2. Fletcher C, Bridge J, Hogendoorn P, Mertens F (2013) WHO classification of tumours of soft tissue and bone. 4. edn. WHO, Lyon

  3. Gurney JG, Davis S, Severson RK et al (1996) Trends in cancer incidence among children in the U.S. Cancer 78(3):532–541

    Article  PubMed  CAS  Google Scholar 

  4. Kyriakos M (2011) Benign notochordal lesions of the axial skeleton: a review and current appraisal. Skeletal Radiol 40(9):1141–1152

    Article  PubMed  Google Scholar 

  5. Mendenhall WM, Zlotecki RA, Scarborough MT et al (2006) Giant cell tumor of bone. Am J Clin Oncol 29(1):96–99

    Article  PubMed  Google Scholar 

  6. Most MJ, Sim FH, Inwards CY (2010) Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg 18(6):358–366

    PubMed  Google Scholar 

  7. Mukherjee D, Chaichana KL, Gokaslan ZL et al (2011) Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. J Neurosurg Spine 14(2):143–150

    Article  PubMed  Google Scholar 

  8. Nakashima Y, Unni KK, Shives TC et al (1986) Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. Cancer 57(12):2444–2453

    Article  PubMed  CAS  Google Scholar 

  9. Nakajima H, Sim FH, Bond JR et al (1997) Small cell osteosarcoma of bone. Review of 72 cases. Cancer 79(11):2095–2106

    Article  PubMed  CAS  Google Scholar 

  10. Nojima T, Unni KK, McLeod RA, Pritchard DJ (1985) Periosteal chondroma and periosteal chondrosarcoma. Am J Surg Pathol 9(9):666–677

    Article  PubMed  CAS  Google Scholar 

  11. Okada K, Frassica FJ, Sim FH et al (1994) Parosteal osteosarcoma. A clinicopathological study. J Bone Joint Surg Am 76(3):366–378

    PubMed  CAS  Google Scholar 

  12. Okada K, Unni KK, Swee RG et al (1999) High grade surface osteosarcoma: a clinicopathologic study of 46 cases. Cancer 85(5):1044–1054

    Article  PubMed  CAS  Google Scholar 

  13. Ottaviani G, Jaffe N (2009) The epidemiology of osteosarcoma. Cancer Treat Res 152:3–13

    Article  PubMed  Google Scholar 

  14. Parkin DM, Whelan SL, Ferlay J et al (1997) Cancer incidence in five continents. IARC Press, Lyon

  15. Present D, Bacchini P, Pignatti G (1991) Clear cell chondrosarcoma of bone. A report of 8 cases. Skeletal Radiol 20(3):187–191

    Article  PubMed  CAS  Google Scholar 

  16. Salzer-Kuntschik M, Delling G, Brand G (1983) Bestimmung des morphologischen Regressionsgrades nach Chemotherapie bei malignen Kochentumoren. Pathologe 4:135

    PubMed  CAS  Google Scholar 

  17. Schajowicz F (1981, 1994) Tumors and tumorlike lesions of bone and joints. Springer, Berlin

  18. Staals EL, Bacchini P, Bertoni F (2006) Dedifferentiated central chondrosarcoma. Cancer 106(12):2682–2691

    Article  PubMed  Google Scholar 

  19. Turc-Carel C, Aurias A, Mugneret F et al (1988) Chromosomes in Ewing’s sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet 32(2):229–238

    Article  PubMed  CAS  Google Scholar 

  20. Unni KK, Inwards CY (2010) Dahlin’s bone tumors: general aspects and data on 11,087 cases, 6. Aufl. Lippincott Williams & Williams, Philadelphia, S 179–183, 310–316

  21. Verdegaal SH, Bovée JV, Pansuriya TC et al (2011) Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist 16(12):1771–1779

    Article  PubMed  Google Scholar 

  22. Wick MR, Siegal GP, Unni KK et al (1981) Sarcomas of bone complicating osteitis deformans (Paget’s disease): fifty years‘ experience. Am J Surg Pathol 5(1):47–59

    Article  PubMed  CAS  Google Scholar 

  23. Wiklund TA, Blomqvist CP, Räty J et al (1991) Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer 68(3):524–531

    Article  PubMed  CAS  Google Scholar 

  24. Wicklund CL, Pauli RM, Johnston D, Hecht JT (1995) Natural history study of hereditary multiple exostoses. Am J Med Genet 55(1):43–46

    Article  PubMed  CAS  Google Scholar 

Download references

Einhaltung der ethischen Richtlinien

Interessenkonflikt. U. Titze und G. Köhler geben an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Gerhard-Domagk-Institut für Pathologie, UK Münster, Albert-Schweitzer-Campus 1, Gebäude D17, Domagkstr. 17, 48149, Münster, Deutschland

    U. Titze & G. Köhler

Authors
  1. U. Titze
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Köhler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to U. Titze.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Titze, U., Köhler, G. Pathomorphologie von Knochensarkomen. Onkologe 19, 620–628 (2013). https://doi.org/10.1007/s00761-013-2511-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00761-013-2511-3

Schlüsselwörter

Keywords

Search

Navigation