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Virtuelle Mikroskopie in der onkologischen Diagnostik

Virtual microscopy in oncological diagnostics

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Der Onkologe Aims and scope

Zusammenfassung

Ähnlich wie die digitalen Verfahren die radiologische Bildgebung revolutioniert haben, wird die virtuelle Mikroskopie die Pathologie verändern. Dies gilt im besonderen Maße auch für die onkologische Diagnostik. Die Digitalisierung wird nicht nur die arbeitsteilige Kooperation der Pathologen vereinfachen und beschleunigen, sondern auch durch die verstärkte Nutzung quantitativer Methoden bei der Einschätzung morphologischer Veränderungen zu geringerer Variabilität und größerer Reproduzierbarkeit verhelfen. Die virtuelle Mikroskopie ermöglicht den Pathologen eine noch aktivere und unmittelbarere Teilnahme an interdisziplinären Tumorkonferenzen.

Abstract

Virtual microscopy will revolutionize pathology similar to the changes in radiological imaging by digitization and this holds especially true for oncological diagnostics. The digitization will simplify and speed up cooperation among pathologists. The intensified use of quantitative methods for the assessment of morphological changes will lead to less variability and increased reproducibility. Virtual microscopy offers pathologists the opportunity to take part in interdisciplinary tumor boards in a more active and direct manner.

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Literatur

  1. Fallon MA, Wilbur DC, Prasad M (2010) Ovarian frozen section diagnosis: use of whole-slide imaging shows excellent correlation between virtual slide and original interpretations in a large series of cases. Arch Pathol Lab Med 134:1020–1023

    PubMed  Google Scholar 

  2. Feldman MD (2008) Beyond morphology: Whole slide imaging, computer-aided detection, and other techniques. Arch Pathol Lab Med 132:758–763

    PubMed  Google Scholar 

  3. Foster K (2010) Medical education in the digital age: digital whole slide imaging as an e-learning tool. J Pathol Inform 1:14

    Article  PubMed  Google Scholar 

  4. Friedberg RC, Pantanowitz L (2009) Practice evolution: decentralized computer-assisted immunohistochemical image analysis. Arch Pathol Lab Med 133:597–600

    PubMed  Google Scholar 

  5. Gilbertson J, Yagi Y (2008) Histology, imaging and new diagnostic work-flows in pathology. Diagn Pathol (Suppl 1):14

    Google Scholar 

  6. Helin H, Lundin M, Lundin J et al (2005) Web-based virtual microscopy in teaching and standardizing Gleason grading. Hum Pathol 36(4):381–386

    Article  PubMed  Google Scholar 

  7. Hufnagl P, Schlüns K (2008) Virtuelle Mikroskopie und Routinediagnostik. Ein Diskussionspapier. Pathologe 29(Suppl 2):250–254

    Article  PubMed  Google Scholar 

  8. Kayser K, Görtler J, Goldmann T et al (2008) Image standards in tissue-based diagnosis (diagnostic surgical pathology). Diagn Pathol 18(3):17

    Article  Google Scholar 

  9. Kayser K, Görtler J, Borkenfeld S, Kayser G (2011) Interactive and automated application of virtual microscopy. Diagn Pathol 6(Suppl 1):10

    Article  Google Scholar 

  10. Ozluk Y, Blanco PL, Mengel M et al (2011) Superiority of virtual microscopy versus light microscopy in transplantation pathology. Clin Transplant. doi: 10.1111/j.1399-0012.2011.01506

  11. Pantanowitz L, Valenstein PN, Evans AJ et al (2011) Review of the current state of whole slide imaging in pathology. J Pathol Inform 2:36

    Article  PubMed  Google Scholar 

  12. Patterson ES, Rayo M, Gill C, Gurcan MN (2011) Barriers and facilitators to adoption of soft copy interpretation from the user perspective: Lessons learned from filmless radiology for slideless pathology. J Pathol Inform 2:1

    Article  PubMed  Google Scholar 

  13. Roßner M, Roßner F, Zwönitzer R et al (2012) Pathowiki. Eine freie Wissensbank für Pathologie. Pathologe 33:1–5

    Article  Google Scholar 

  14. Saeger K, Schlüns K, Hamann K et al (2006) Digitale Virtuelle Mikroskopie als modernes Kommunikationsmedium in der Pathologie. In: Jäckel A (Hrsg) Telemedizinführer D. 2006 7. Ausgabe. Minerva, Darmstadt, S 104–108

  15. Schrader T, Hufnagl P, Schlake W, Dietel M (2005) Study of efficiancy of teleconsultation: the telepathology consultation service of the Professional Assoziation of German Pathologists for the screening program of breast carcinoma. Verh Dtsch Ges Pathol 89:211–218

    PubMed  CAS  Google Scholar 

  16. Sinn HP, Andrulis M, Mogler C, Schirmacher P (2008) Virtual microscopy in pathology teaching and postgraduate training (continuing education). Pathologe 29(2 Suppl):255–258

    Article  PubMed  Google Scholar 

  17. Tecotzky R (2009) Digital pathology enhances hospital’s tumor board meetings. Medical Laboratory Observer, S 60

  18. Thorstenson S (2010) Digital routine histopathology. The future is here! 10th European Congress on Telepathology and 4th International Congress on Virtual Microscopy. Vilnius, Lithuania 1–3 July, http://www.telepathology2010.com/uploads/_fck/1_vilnius_digital_routine_histopathology_[compatibility_mode].pdf

  19. Tuominen VJ, Isola J (2009) The application of JPEG2000 in virtual microscopy. J Digit Imaging 22:250–258

    Article  PubMed  Google Scholar 

  20. Weinstein RS, Graham AR, Richter LC et al (2009) Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 40:1057–1069

    Article  PubMed  Google Scholar 

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Interessenkonflikt

Der korrespondierende Autor weist auf folgenden Beziehungen hin: Prof. Dr. Hufnagl und Dr. Schlüns sind Gesellschafter der VMscope GmbH Berlin.

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Correspondence to P. Hufnagl.

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Hufnagl, P., Zerbe, N. & Schlüns, K. Virtuelle Mikroskopie in der onkologischen Diagnostik. Onkologe 18, 409–418 (2012). https://doi.org/10.1007/s00761-012-2233-y

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