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Mammakarzinom in der Schwangerschaft

Breast cancer during pregnancy

  • Leitthema
  • Published:
Der Onkologe Aims and scope

Zusammenfassung

Zirka 1% aller Mammakarzinome werden während der Schwangerschaft diagnostiziert. Aufgrund der Seltenheit und der besonderen Umstände stammen die meisten Daten aus Fallserien und Kohortenstudien. Die Frauen sollen und können so nah wie möglich am Standard für junge, nichtschwangere Mammakarzinompatientinnen behandelt werden. Alle Patientinnen mit Mammakarzinom in der Schwangerschaft sollten in der Registerstudie der GBG gemeldet werden (http://www.germanbreastgroup.de/pregnancy).

Abstract

Breast cancer occurs in 1% of pregnancies and due to the rarity and special circumstances most data are from case series and cohort studies. It is currently recommended to treat these patients as closely as possible to the standard procedure for non-pregnant young women. All patients with breast cancer during pregnancy should be included in the register study of the German Breast Group (http://www.germanbreastgroup.de/pregnancy).

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Literatur

  1. Stensheim H, Moller B, Dijk T van, Fossa SD (2009) Cause specific survival for women diagnosed with cancer during pregnancy and lactation: a registry based cohort study. J Clin Oncol 27:45–51

    Article  PubMed  Google Scholar 

  2. Loibl S, Amant F, Kaufmann M et al (2010) 313 patients with breast cancer during pregnancy-a prospective and retrospective registry (GBG-20/BIG02–03). Cancer Res Cancer Res 70(No 24 Suppl):S6–S2, Page: 91s, Abstract

  3. Petrek JA, Dukoff R, Rogatko A (1991) Prognosis of pregnancy associated breast cancer. Cancer 67:869–872

    Article  PubMed  CAS  Google Scholar 

  4. Anders CK, Hsu DS, Broadwater G et al (2008) Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 26:3324–3330

    Article  PubMed  Google Scholar 

  5. Loibl S, Minckwitz von, Gwyn K et al (2006) Breast carcinoma during pregnancy. Recommendations from an International Expert Meeting. Cancer 106:237–246

    Article  PubMed  Google Scholar 

  6. Amant F, Deckers S, Van Calsteren K et al (2010) Breast cancer in pregnancy: recommendations of an international consensus meeting. Eur J Cancer 46:3158–3168

    Article  PubMed  Google Scholar 

  7. Dominici LS, Kuerer HM, Babiera G et al (2010) Wound complications from surgery in pregnancy-associated breast cancer (PABC). Breast Dis 31:1–5

    PubMed  Google Scholar 

  8. http://www.ago-online.de

  9. Gentilini O, Cremonesi M, Trifiro G (2004) Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 15:1348–1351

    Article  PubMed  CAS  Google Scholar 

  10. Mondi MM, Cuenca RE, Ollila DW et al (2007) Sentinel lymph node biopsy during pregnancy: initial clinical experience. Ann Surg Oncol 14:218–221

    Article  PubMed  Google Scholar 

  11. Gentilini O, Cremonesi M, Trifiro G et al (2004) Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 15:1348–51

    Article  PubMed  CAS  Google Scholar 

  12. Gentilini O, Cremonesi M, Toesca A et al (2010) Sentinel lymph node biopsy in pregnant patients with breast cancer. Eur J Nucl Med Mol Imaging 37:78–83

    Article  PubMed  Google Scholar 

  13. Crivellaro M, Senna G, Dama A et al (2003) Anaphylaxis due to patent blue dye during lymphography, with negative skin prick test. J Investig Allergol Clin Immunol 13:71–72

    PubMed  Google Scholar 

  14. Kal HB, Struikmans H (2005) Radiotherapy during pregnancy: fact and fiction. Lancet Oncol 6:328–333

    Article  PubMed  Google Scholar 

  15. Hebert-Croteau N, Freeman CR, Latreille J et al (2004) A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer. Breast Cancer Res Treat 88:187–196

    Article  PubMed  Google Scholar 

  16. Berry DL, Theriault RL, Holmes FA et al (1999) Management of breast cancer during pregnancy using a standardized protocol. J Clin Oncol 17:855–861

    PubMed  CAS  Google Scholar 

  17. Ring AE, Smith IE, Jones A et al (2005) Chemotherapy for breast cancer during pregnancy: an 18-year experience from five London teaching hospitals. J Clin Oncol 23:4192–4197

    Article  PubMed  Google Scholar 

  18. Aviles A, Neri N (2001) Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma 2:173–177

    Article  PubMed  CAS  Google Scholar 

  19. Hahn KM, Johnson PH, Gordon N et al (2006) Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer 107:1219–1226

    Article  PubMed  Google Scholar 

  20. Loibl S (2008) New therapeutic options for breast cancer during pregnancy. Breast Care 3:171–176

    Article  PubMed  Google Scholar 

  21. Mir O, Berveiller P, Goffinet F et al (2010) Taxanes for breast cancer during pregnancy: a systematic review. Ann Oncol 21:425–426

    Article  PubMed  CAS  Google Scholar 

  22. Smit JW, Huisman MT, Tellingen O van et al (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest 104:1441–1447

    Article  PubMed  CAS  Google Scholar 

  23. Cunha GR, Taguchi O, Namikawa R et al (1987) Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract. Hum Pathol 18:1132–1143

    Article  PubMed  CAS  Google Scholar 

  24. Aebi S, Loibl S (2008) Breast Cancer during pregnancy. Recent Results Cancer Res 178:45–55

    Article  PubMed  CAS  Google Scholar 

  25. Diel IJ, Solomayer EF, Costa SD et al (1998) Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl J Med 339:357–363

    Article  PubMed  CAS  Google Scholar 

  26. Halaska MJ, Pentheroudakis G, Strnad P et al (2009) Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study. Breast J 15:461–467

    Article  PubMed  Google Scholar 

  27. Ibrahim EM, Ezzat AA, Baloush A et al (2000) Pregnancy-associated breast cancer: a case-control study in a young population with a high-fertility rate. Med Oncol 17:293–300

    Article  PubMed  CAS  Google Scholar 

  28. Zhang J, Liu G, Wu J et al (2003) Pregnancy-associated breast cancer: a case control and long-term follow-up study in China. J Exp Clin Cancer Res 22:23–27

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. German Breast Group Neu-Isenburg und Stadtkrankenhaus Offenbach, Martin-Behaim-Straße 12, 63263, Neu-Isenburg, Deutschland

    S. Loibl

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  1. S. Loibl
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Correspondence to S. Loibl.

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Weitere Informationen zu diesem Beitrag erhalten Sie unter http://www.germanbreastgroup.de/pregnancy oder bei der Autorin.

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Loibl, S. Mammakarzinom in der Schwangerschaft. Onkologe 18, 338–343 (2012). https://doi.org/10.1007/s00761-012-2219-9

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  • DOI: https://doi.org/10.1007/s00761-012-2219-9

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