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Anatomie und Pathologie der zentralen Gallengangstumoren

Anatomy and pathology of perihilar extrahepatic bile duct tumors (Klatskin tumors)

Der Onkologe volume 16, pages 841–848 (2010)Cite this article

Zusammenfassung

Adenokarzinome der Gallengänge (sog. Cholangiokarzinome) können von den intrahepatischen und extrahepatischen Gängen ausgehen und sind seltene Tumoren. Als besondere Tumorentität wurden Karzinome der perihilären oder zentralen extrahepatischen Gallengänge (sog. Klatskin-Tumoren) abgegrenzt. Patienten mit solchen Karzinomen haben eine schlechte Prognose. Da die operativen Möglichkeiten sich ebenso verbessert haben wie die konservat iven Therapieansätze, wurden differenzierte TNM-Klassifikationen für Karzinome der verschiedenen Abschnitte des Gallengangssystems eingeführt, um die anatomische Ausbreitung möglichst genau beschreiben zu können. Die in der 7. Auflage der TNM-Klassifikation maligner Tumoren eingeführten neuen Klassifikationen bzw. Änderungen bestehender Klassifikationen beruhen auf Daten aus Asien und den USA. Die neue Klassifikation soll ab 01.01.2010 verbindlich angewendet werden.

Abstract

Adenocarcinomas of the bile ducts (so-called cholangiocarcinomas) may originate from both intrahepatic and extrahepatic bile ducts and constitute a rare tumor entity. Carcinomas of the perihilar and central extrahepatic bile ducts (so-called Klatskin’s tumors) are demarcated as special tumor entities and patients with these carcinomas face a poor prognosis. As therapeutic options have improved with respect to both operative and conservative treatment strategies, sophisticated TNM classifications for the different parts of the bile duct system have been introduced in order to determine the anatomic spread as accurately as possible. The new classifications and modifications of the 7th edition are based on data from Asia and the U.S. Application of the new classifications is mandatory as of 1st January 2010.

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  1. Institut für Pathologie, Universitätklinikum Leipzig, Liebigstraße 26, 04103, Leipzig, Deutschland

    C. Wittekind & B. Oberschmid

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Wittekind, C., Oberschmid, B. Anatomie und Pathologie der zentralen Gallengangstumoren. Onkologe 16, 841–848 (2010). https://doi.org/10.1007/s00761-010-1878-7

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