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Pathogenese, Klassifikation und Histologie von Schilddrüsenkarzinomen

Pathogenesis, classification, and histology of thyroid cancer

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Zusammenfassung

Schilddrüsenkarzinome machen ca. 1% aller menschlichen Malignome aus und werden aufgrund ihrer Morphologie in Karzinome mit Follikelzell- und C-Zell-Differenzierung sowie seltene Karzinomformen unterteilt. Umfassende molekulargenetische Erkenntnisse unterstützen die morphologische Diagnostik und erlauben Einsicht in die Entstehungs- und Progressionsmechanismen dieser Tumoren. Der vorliegende Übersichtsartikel beschreibt die Pathogenese, Klassifikation und Histologie der unterschiedlichen Karzinomentitäten der Schilddrüse. Eine exakte histologische Klassifikation der Schilddrüsenkarzinome, ggf. unter Anwendung immunhistochemischer und/oder molekulargenetischer Untersuchungen, ist für das therapeutische Management der Patienten nach wie vor unabdingbar.

Abstract

Thyroid cancer makes up approximately 1% of all human malignancies. Morphologically thyroid cancer can be subdivided into carcinomas with follicular cell differentiation, C cell differentiation and other rare carcinoma types. Recent molecular genetic discoveries provide insight into the mechanisms of the development and progression of thyroid carcinoma and furthermore offer perfect tools to support the morphological diagnosis. Exact histological classification of thyroid carcinomas is still the gold standard for the therapeutic management of thyroid carcinoma patients, if necessary based on immunohistochemical and/or molecular pathological findings.

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  1. Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    K.W. Schmid

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Schmid, K. Pathogenese, Klassifikation und Histologie von Schilddrüsenkarzinomen. Onkologe 16, 644–656 (2010). https://doi.org/10.1007/s00761-010-1872-0

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