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Histopathologie des Endometriumkarzinoms

Histopathology of endometrial carcinoma

Der Onkologe volume 15, pages 1239–1242 (2009)Cite this article

Zusammenfassung

Das Endometriumkarzinom ist ein häufiger Tumor mit vielen histopathologischen Varianten. Die meisten Fälle werden als Typ-I-Tumoren klassifiziert, zeigen eine endometrioide Morphologie, sind von niedrigem Grad und Stadium, und die Fünfjahresüberlebensrate ist ausgezeichnet. Typ-II-Tumoren sind viel seltener, es handelt sich hauptsächlich um seröse Karzinome, und die Typ-II-Tumoren sind ohne Ausnahme hoch aggressiv. Die klinische Zweiteilung zeigt sich auch anhand der reproduzierbaren molekulargenetischen Alterationen, die für jeden Typ spezifisch sind. Über die den Typ-II-Tumoren zugrunde liegenden Genmutationen ist weniger bekannt, und es bleibt abzuwarten, ob die Klarzellkarzinome des Endometriums als Typ I oder II eingestuft werden können oder ob sie sich dieser Klassifikation weiterhin entziehen.

Abstract

Endometrial carcinoma is a common malignancy with numerous histopathologic variants. The majority of cases are classified as type I tumors, show endometrioid morphology, are low grade and low stage and have excellent 5-year survival. Type II tumors are much less common, are predominantly serous carcinomas and are uniformly highly aggressive. This clinical dichotomy is reflected in and supported by reproducible molecular genetic alterations specific to each type. Less is known about the underlying genetic mutations for the rarer type II tumors and it is yet to be determined if clear cell carcinoma of the endometrium will be classifiable as type I, type II or will remain an outlier in this classification.

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Authors and Affiliations

  1. Departments of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine and Hospital, Weinberg 2242, 21231, Baltimore, MD, USA

    R.J. Kurman M.D.

  2. Departments of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD, USA

    R.J. Kurman M.D. & T.G. McConnell

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  1. R.J. Kurman M.D.
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  2. T.G. McConnell
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Kurman, R., McConnell, T. Histopathologie des Endometriumkarzinoms. Onkologe 15, 1239–1242 (2009). https://doi.org/10.1007/s00761-009-1728-7

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  • DOI: https://doi.org/10.1007/s00761-009-1728-7

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