Abstract
Als systemischer Entzündungsprozess ist die Arteriosklerose charakterisiert durch die Entstehung von Plaques, Plaqueruptur und/oder Plaqueerosion, die zum Myokardinfarkt führen. Intravaskulärer Ultraschall, MRT und drei-dimensionaler Carotis-Ultraschall sind in der Lage, Plaques auf der Basis ihrer Morphologie und Zusammensetzung darzustellen, können aber nur bedingt die molekulare Typisierung bzw. zuverlässige Unterscheidung zwischen vulnerablen, rupturgefährdeten und stabilen Plaques erreichen. Die molekulare Bildgebung stellt nun in vielerlei Hinsicht eine wichtige komplementäre Säule der modernen präklinischen und klinischen Bildgebung dar (Abb. 1).
References
Stary HC et al.: A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis. American Heart Association. Circulation 85(1), 391–405 (1992)
Rudd JH, Davies JR, Weissberg PL.: Imaging of atherosclerosis – can we predict plaque rupture?. Trends Cardiovasc Med 15(1), 17–24 (2005)
Tawakol A et al.: In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol. 48(9), 1818–24 (2006)
Tahara N et al.: Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol. 48(9), 1825–31 (2006)
Kooi ME et al.: Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 107(19), 2453–8 (2003)
Trivedi RA et al.: In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 35(7), 1631–5 (2004)
Deguchi JO et al.: Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation 114(1), 55–62 (2006)
Winter PM et al.: Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol 26(9), 2103–9 (2006)
Briley-Saebo KC et al.: Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation 117(25), 3206–15 (2008)
Hansson EM, Lindsay ME, Chien KR: Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell 5(4), 364–77 (2009)
Segers VF, Lee RT.: Stem-cell therapy for cardiac disease. Nature 451(7181), 937–42 (2008)
Lipinski MJ et al.: Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol 50(18), 1761–7 (2007)
Terrovitis J et al.: Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by singlephoton emission computed tomography or positron emission tomography. J Am Coll Cardiol 52(20), 1652–60 (2008)
Wu JC et al.: Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation 108(11), 1302–5 (2003)
Liu J et al.: Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter. Tissue Eng Part C Methods 15(4), 739–47 (2009)
Chen IY et al.: Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery. Circulation 109(11), 1415–20 (2004)
Hofmann M et al.: Monitoring of bone marrow cell homing into the inarcted human myocardium. Circulation 111(17), 2198–202 (2005)
Karpov RS et al.: Autologous mononuclear bone marrow cells during reparative regeneratrion after acute myocardial infarction. Bull Exp Biol Med 140(5), 640–3 (2005)
Kang WJ et al.: Tissue distribution of 18FFDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction. J Nucl Med 47(8), 1295–301 (2006)
Brott T, Bogousslavsky J.: Treatment of acute ischemic stroke. N Engl J Med 343(10), 710–22 (2000)
Virmani R et al.: Vulnerable plaque: the pathology of unstable coronary lesions. J Interv Cardiol 15(6), 439–46 (2002)
Terai T, Nagano T.: Fluorescent probes for bioimaging applications. Curr Opin Chem Biol 12(5), 515–21 (2008)
Jaffer FA, Libby P, Weissleder R.: Optical and multimodality molecular imaging: insights into atherosclerosis. Arterioscler Thromb Vasc Biol 29(7), 1017–24 (2009)
Aikawa M, Libby P.: The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol 13(3), 125–38 (2004)
Virmani R et al. Pathology of the vulnerable plaque. J Am Coll Cardiol, 2006. 47(8 Suppl): p. C13–8
Papaspyridonos M et al.: Novel candidate genes in unstable areas of human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 26(8), 1837–44 (2006)
Chen J et al.: In vivo imaging of proteolytic activity in atherosclerosis. Circulation 105(23), 2766–71 (2002)
Winter PM et al.: Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles. Circulation 108(18), 2270–4 (2003)
Sarai M et al.: Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging. J Am Coll Cardiol 50(24), 2305–12 (2007)
Zhu Y, Carmeliet P, Fay WP.: Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. Circulation 99(23), 3050–5 (1999)
Stassen JM, Arnout J, Deckmyn H.: The hemostatic system. Curr Med Chem 11(17), 2245–60 (2004)
Jaffer FA et al.: Molecular imaging of factor XIIIa activity in thrombosis using a novel, nearinfrared fluorescent contrast agent that covalently links to thrombi. Circulation 110(2), 170–6 (2004)
Levy LM, Hallett M.: Impaired brain GABA in focal dystonia. Ann Neurol 51(1), 93–101 (2002)
Schmidt KE et al.: Striatal activation during blepharospasm revealed by fMRI. Neurology 60(11), 1738–43 (2003)
de Vries PM et al.: Changed patterns of cerebral activation related to clinically normal hand movement in cervical dystonia. Clin Neurol Neurosurg 110(2), 120–8 (2008)
Peller M et al. The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer’s cramp. Brain, 2006. 129(Pt 10): p. 2697–708
Bassareo V, Di Chiara G.: Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. Eur J Neurosci 11(12), 4389–97 (1999)
Wang GJ et al.: Brain dopamine and obesity. Lancet 357(9253), 354–7 (2001)
Small DM et al. Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain, 2001. 124(Pt 9): p. 1720–33
Stoeckel LE et al.: Widespread reward-system activation in obese women in response to pictures of high-calorie foods. Neuroimage 41(2), 636–47 (2008)
Villemagne VL et al.: Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias. J Nucl Med 52(8), 1210–7 (2011)
Sourbron S et al.: Quantification of cerebral blood flow, cerebral blood volume, and bloodbrain-barrier leakage with DCE-MRI. Magn Reson Med 62(1), 205–17 (2009)
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Cyran, C.C., Rist, C., Paprottka, P.M. et al. Funktionelle und Molekulare Bildgebung – Aktueller Stand. Wien klin Mag 14, 12–16 (2011). https://doi.org/10.1007/s00740-011-419-3
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DOI: https://doi.org/10.1007/s00740-011-419-3