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Dopamin-Dysregulations-Syndrom bei Morbus Parkinson

Der zwanghafte Missbrauch der dopaminergen Therapie

Dopaminergic dysregulation syndrome in Parkinson’s disease

The compulsive abuse of dopaminergic therapy

  • Neurologie
  • Published:
psychopraxis. neuropraxis Aims and scope Submit manuscript

Zusammenfassung

Morbus Parkinson ist eine neurodegenerative Erkrankung mit den Kardinalsymptomen Bradykinese, Rigor und Tremor. Bereits 1817 beschrieb James Parkinson in seinem „Essay on the shaking palsy“ zusätzlich zu den motorischen Symptomen auch autonome und kognitive Störungen sowie Verhaltensauffälligkeiten (Parkinson, An essay on the shaking palsy. Sherwood, Nealy and Jones, London, 1817). Deren Einfluss auf die Lebensqualität der Patienten wurde jedoch lange Zeit unterschätzt. Das dopaminerge Dysregulationssysndrom (DDS) ist eine iatrogene Störung, wobei es zu einem zwanghaften Medikamentenmissbrauch in der dopaminergen Therapie kommt. Trotz objektiv guter Beweglichkeit fühlen sich diese Patienten oft untertherapiert und steigern die dopaminerge Therapie weit über die erforderliche Dosis. In weiterer Folge kommt es zu Verhaltensauffälligkeiten sowie sozialen und beruflichen Problemen.

Abstract

Parkinson’s disease is a neurodegenerative disease with the cardinal symptoms bradykinesia, rigidity and tremor. In 1817, James Parkinson already described in his "Essay on the Shaking Palsy" in addition to the motor symptoms also autonomic, cognitive and behavioral disturbances (Parkinson, An essay on the shaking palsy. Sherwood, Nealy and Jones, London, 1817). Their impact on quality of life has been underestimated until more recent times. Dopamine dysregulation syndrome is an iatrogenic disturbance, characterized by an addictive pattern of dopamine replacement therapy use. Despite good control of motor symptoms, patients often increase doses of dopamine replacement therapy in excess of those normally required. Consequently these behavioral disorders may also result in social and professional problems.

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C. Weber gibt an, dass kein Interessenskonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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  1. Univ.-Klinik für Neurologie, Medizinische Universität Wien, Währinger Gürtel 18–20, 1090, Wien, Österreich

    Corinna Weber

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  1. Corinna Weber
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Correspondence to Corinna Weber.

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Weber, C. Dopamin-Dysregulations-Syndrom bei Morbus Parkinson. psychopraxis. neuropraxis 17, 19–22 (2014). https://doi.org/10.1007/s00739-014-0191-4

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  • DOI: https://doi.org/10.1007/s00739-014-0191-4

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