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Archives of Women's Mental Health

, Volume 17, Issue 3, pp 213–219 | Cite as

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

  • Monique Robinson
  • Andrew J. O. Whitehouse
  • John P. Newnham
  • Shelley Gorman
  • Peter Jacoby
  • Barbara J. Holt
  • Michael Serralha
  • Jessica E. Tearne
  • Pat G. Holt
  • Prue H. Hart
  • Merci M. H. Kusel
Original Article

Abstract

Pregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with depressive symptoms. However, the link between 25(OH)-vitamin D status in pregnancy and altered risk of postnatal depressive symptoms has not been examined. We hypothesise that low levels of 25(OH)-vitamin D in maternal serum during pregnancy will be associated with a higher incidence of postpartum depressive symptoms. We prospectively collected sera at 18 weeks gestation from 796 pregnant women in Perth (1989–1992) who were enrolled in the Western Australian Pregnancy Cohort (Raine) Study and measured levels of 25(OH)-vitamin D. Women reported postnatal depressive symptoms at 3 days post-delivery. Women in the lowest quartile for 25(OH)-vitamin D status were more likely to report a higher level of postnatal depression symptoms than women who were in the highest quartile for vitamin D, even after accounting for a range of confounding variables including season of birth, body mass index and sociodemographic factors. Low vitamin D during pregnancy is a risk factor for the development of postpartum depression symptoms.

Keywords

Vitamin D Postpartum blues Perinatal mental health Environmental exposure Postnatal depression 

Notes

Acknowledgments

We acknowledge the support via core funding from the Raine Medical Research Foundation, The University of Western Australia (UWA), the Telethon Institute for Child Health Research, the UWA Faculty of Medicine, Dentistry and Health Science, the Women and Infants Research Foundation and Curtin University. The Raine Study is also funded by the National Health and Medical Research Council of Australia (NHMRC; Grant Nos. 963209, 211912, 003209 and 353514), Australian Health Management, the Telstra Foundation, the Western Australian Health Promotion Foundation, the National Heart Foundation of Australia and Beyond Blue. Dr. Robinson is funded for this research by Australian Rotary Health and the NHMRC. A/Prof Whitehouse is supported by a NHMRC Career Development Fellowship (no. 1004065). We thank biostatistician Patrick Fitzgerald for his assistance with the paper. We are extremely grateful to all the families who took part in this study and the Raine Study team, which includes data collectors, cohort managers, data managers, clerical staff, research scientists and volunteers.

Conflict of interest

The authors have no conflicts of interest to declare.

References

  1. Bertone-Johnson ER (2009) Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr Rev 67(8):481–492PubMedCentralPubMedCrossRefGoogle Scholar
  2. Blair E, Liu Y, de Klerk N, Lawrence D (2005) Optimal fetal growth for the Caucasian singleton and assessment of appropriateness of fetal growth: an analysis of a total population perinatal database. BMC Pediatr 5(1):13PubMedCentralPubMedCrossRefGoogle Scholar
  3. Cannell JJ (2008) Autism and vitamin D. Med Hypotheses 70(4):750–759PubMedCrossRefGoogle Scholar
  4. Carter GD (2011) Accuracy of 25-hydroxyvitamin D assays: confronting the issues. Curr Drug Targets 12(1):19–28PubMedCrossRefGoogle Scholar
  5. Corder EH, Guess HA, Hulka BS, Friedman GD, Sadler M, Vollmer RT, Lobaugh B, Drezner MK, Vogelman JH, Orentreich N (1993) Vitamin D and prostate cancer: a prediagnostic study with stored sera. Cancer Epidemiol Biomarkers Prev 2(5):467–472PubMedGoogle Scholar
  6. Cox JL, Holden JM, Sagovsky R (1987) Detection of postnatal depression—development of the 10-item Edinburgh postnatal depression scale. Br J Psychiatry 150:782–786. doi: 10.1192/bjp.150.6.782 PubMedCrossRefGoogle Scholar
  7. Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62(1):68–77PubMedCentralPubMedCrossRefGoogle Scholar
  8. Ganji V, Milone C, Cody MM, McCarty F, Wang YT (2010) Serum vitamin D concentrations are related to depression in young adult US population: the Third National Health and Nutrition Examination Survey. Int Arch Med 3:29PubMedCentralPubMedCrossRefGoogle Scholar
  9. Ginde AA, Sullivan AF, Mansbach JM, Camargo CA Jr (2010) Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol 202(5):e431–438, 436Google Scholar
  10. Henshaw C, Foreman D, Cox J (2004) Postnatal blues: a risk factor for postnatal depression. J Psychosom Obstet Gynecol 25(3–4):267–272CrossRefGoogle Scholar
  11. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281PubMedCrossRefGoogle Scholar
  12. Holmes VA, Barnes MS, Alexander HD, McFaul P, Wallace JM (2009) Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 102(6):876–881PubMedCrossRefGoogle Scholar
  13. Howland RH (2011) Vitamin D and depression. J Psychosoc Nurs Ment Health Serv 49(2):15–18PubMedCrossRefGoogle Scholar
  14. Maunsell Z, Wright DJ, Rainbow SJ (2005) Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3. Clin Chem 51(9):1683–1690PubMedCrossRefGoogle Scholar
  15. McCann JC, Ames BN (2008) Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 22(4):982–1001PubMedCrossRefGoogle Scholar
  16. McGrath JJ, Burne TH, Feron F, Mackay-Sim A, Eyles DW (2010) Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 36(6):1073–1078PubMedCentralPubMedCrossRefGoogle Scholar
  17. Milman N, Hvas AM, Bergholt T (2011) Vitamin D status during normal pregnancy and postpartum. A longitudinal study in 141 Danish women. J Perinat Med 40(1):57–61. doi: 10.1515/JPM.2011.120 PubMedGoogle Scholar
  18. Murphy PK, Wagner CL (2008) Vitamin D and mood disorders among women: an integrative review. J Midwifery Womens Health 53(5):440–446PubMedCrossRefGoogle Scholar
  19. Murphy PK, Mueller M, Hulsey TC, Ebeling MD, Wagner CL (2010) An exploratory study of postpartum depression and vitamin D. J Am Psychiatr Nurses Assoc 16(3):170–177PubMedCrossRefGoogle Scholar
  20. Najman J, Williams GM, Nikles J, Spence S, Bor W, O'Callaghan M, Le Brocque R, Andersen M, Shuttlewood G (2001) Bias influencing maternal reports of child behaviour and emotional state. Soc Psychiatry Psychiatr Epidemiol 36(4):186–194PubMedCrossRefGoogle Scholar
  21. Newnham JP, Evans SF, Michael CA, Stanley FJ, Landau LI (1993) Effects of frequent ultrasound during pregnancy: a randomised controlled trial. Lancet 342:887–891PubMedCrossRefGoogle Scholar
  22. Nomura AM, Stemmermann GN, Lee J, Kolonel LN, Chen TC, Turner A, Holick MF (1998) Serum vitamin D metabolite levels and the subsequent development of prostate cancer (Hawaii, United States). Cancer Causes Control 9(4):425–432PubMedCrossRefGoogle Scholar
  23. Nowson CA, Margerison C (2002) Vitamin D intake and vitamin D status of Australians. Med J Aust 177(3):149–152PubMedGoogle Scholar
  24. Robinson M, Oddy WH, Li J, Kendall GE, de Klerk NH, Silburn SR, Zubrick SR, Newnham JP, Stanley FJ, Mattes E (2008) Pre- and postnatal influences on preschool mental health: a large-scale cohort study. J Child Psychol Psychiatry 49(10):1118–1128PubMedCrossRefGoogle Scholar
  25. Robinson M, Kendall GE, Jacoby P, Hands B, Beilin LJ, Silburn SR, Zubrick SR, Oddy WH (2011) Lifestyle and demographic correlates of poor mental health in early adolescence. J Paediatr Child Health 47(1):54–61PubMedGoogle Scholar
  26. Sanders KM, Stuart AL, Williamson EJ, Jacka FN, Dodd S, Nicholson G, Berk M (2011) Annual high-dose vitamin D3 and mental well-being: randomised controlled trial. Br J Psychiatry 198(5):357–364. doi: 10.1192/bjp.bp.110.087544 PubMedCrossRefGoogle Scholar
  27. Shipowick CD, Moore CB, Corbett C, Bindler R (2009) Vitamin D and depressive symptoms in women during the winter: a pilot study. Appl Nurs Res 22(3):221–225. doi: 10.1016/j.apnr.2007.08.001 PubMedCrossRefGoogle Scholar
  28. SPSS Inc. (2006) SPSS 15.0 for Windows. ChicagoGoogle Scholar
  29. Tare M, Parkington HC, Morley R (2006) Vitamin D in pregnancy and offspring health. In: Wintour EM, Owens JA (eds) Early life origins of health and disease. Springer, New YorkGoogle Scholar
  30. van der Mei IAF, Ponsonby AL, Dwyer T, Blizzard L, Taylor BV, Kilpatrick T, Butzkueven H, McMichael AJ (2007) Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. J Neurol 254(5):581–590PubMedCrossRefGoogle Scholar
  31. Viljakainen HT, Saarnio E, Hytinantti T, Miettinen M, Surcel H, Makitie O, Andersson S, Laitinen K, Lamberg-Allardt C (2010) Maternal vitamin D status determines bone variables in the newborn. J Clin Endocrinol Metab 95(4):1749–1757. doi: 10.1210/jc.2009-1391 jc.2009-1391 PubMedCrossRefGoogle Scholar
  32. Whitehouse AJO, Holt BJ, Serralha M, Holt PG, Kusel MMH, Hart PH (2012) Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics 129(3):485–493PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Monique Robinson
    • 1
  • Andrew J. O. Whitehouse
    • 1
    • 2
  • John P. Newnham
    • 3
  • Shelley Gorman
    • 1
  • Peter Jacoby
    • 1
  • Barbara J. Holt
    • 1
  • Michael Serralha
    • 1
  • Jessica E. Tearne
    • 1
    • 2
  • Pat G. Holt
    • 1
  • Prue H. Hart
    • 1
  • Merci M. H. Kusel
    • 1
  1. 1.Telethon Kids InstituteThe University of Western AustraliaPerthAustralia
  2. 2.School of PsychologyThe University of Western AustraliaPerthAustralia
  3. 3.School of Women’s and Infants’ HealthThe University of Western AustraliaPerthAustralia

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