Archives of Women's Mental Health

, Volume 16, Issue 6, pp 499–509 | Cite as

Association study of the estrogen receptor gene ESR1 with postpartum depression—a pilot study

  • Julia K. Pinsonneault
  • Danielle Sullivan
  • Wolfgang Sadee
  • Claudio N. Soares
  • Elizabeth Hampson
  • Meir Steiner
Original Article

Abstract

Perinatal mood disorders, such as postpartum depression (PPD), are costly for society, with potentially serious consequences for mother and child. While multiple genes appear to play a role in PPD susceptibility, the contributions of specific genetic variations remain unclear. Previously implicated as a candidate gene, the estrogen receptor alpha gene (ESR1) is a key player in mediating hormonal differences during pregnancy and the postpartum period. This study addresses genetic factors in perinatal mood disorders, testing nine polymorphisms in ESR1. Two hundred fifty-seven postpartum women were screened for mood disorders, including 52 women with PPD and 32 without any symptoms of mood disorders. We detected a significant association for the upstream TA microsatellite repeat with Edinburgh Postnatal Depression Scale scores (p = 0.007). The same variant was also associated with the occurrence of PPD. Separately, 11 candidate functional polymorphisms in 7 additional genes were genotyped to investigate gene–gene interaction with the ESR1 TA repeat, identifying a potential interaction with the serotonin transporter. Our results support a role for ESR1 in the etiology of PPD, possibly through the modulation of serotonin signaling. Our findings for ESR1 could have broad implications for other disorders and therapies that involve estrogens.

Keywords

Postpartum depression Edinburgh postnatal depression scale ESR1 estrogen receptor Genetic variation SNP 

List of abbreviations

PPD

postpartum depression

SNP

single nucleotide polymorphism

LD

linkage disequilibrium

MAF

minor allele frequency

MADRS

Montgomery–Asberg Depression Rating Scale

EPDS

Edinburgh Postnatal Depression Scale

SCID

Stuctured Clinical Interview for DSM Disorders

MINI

Mini International Neuropsychiatric Interview

MDD

Major depressive disorder

GAD

Generalized anxiety disorder

Supplementary material

737_2013_373_MOESM1_ESM.pdf (140 kb)
Figure S1A): A histogram of EPDS score distribution.): The Q-Q plot of linear regression with ‘EPDS’ as the outcome. All residuals appeared fine (plots C and D), and any log-transform of the outcome made the residuals significantly worse. C): A Q-Q plot for the residuals from the interaction model showing that normality is not violated. D): Residuals vs. fitted values demonstrating that the assumption of constant variance is not violated, and they also appear, for the most part, centered at zero. All model assumptions appear satisfied. (PDF 139 kb)
737_2013_373_MOESM2_ESM.pdf (27 kb)
Table S1Genes represented by SNP genotyping in our analysis. (PDF 26 kb)
737_2013_373_MOESM3_ESM.pdf (23 kb)
Table S2Genotyping primers for non-ESR1 variants except COMT rs4680, which was genotyped with a commercially available TaqMan assay (Life Technologies). (PDF 24 kb) (PDF 23 kb)
737_2013_373_MOESM4_ESM.pdf (23 kb)
Table S3Additional SNP information (PDF 22 kb)
737_2013_373_MOESM5_ESM.pdf (24 kb)
Table S4Genetic association summary of functional polymorphisms in the additional seven candidate genes with EPDS score. (PDF 24 kb)

References

  1. Ahokas A, Aito M, Rimon R (2000) Positive treatment effect of estradiol in postpartum psychosis: a pilot study. J Clin Psychiatry 61:166–169PubMedCrossRefGoogle Scholar
  2. Albrecht E, Pepe G (1990) Placental steroid hormone biosynthesis in primate pregnancy. Endocrinol Rev 11:124–150CrossRefGoogle Scholar
  3. Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL, Epperson CN (2006) The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacol Biochem Behav 84(4):635–643PubMedCrossRefGoogle Scholar
  4. Anghel A, Narita D, Seclaman E, Popovici E, Anghel M, Tamas L (2010) Estrogen receptor alpha polymorphisms and the risk of malignancies. Pathol Oncol Res 16(4):485–496. doi:10.1007/s12253-010-9263-9 PubMedCrossRefGoogle Scholar
  5. Anguelova M, Benkelfat C, Turecki G (2003a) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 8(6):574–591PubMedCrossRefGoogle Scholar
  6. Anguelova M, Benkelfat C, Turecki G (2003b) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 8(7):646–653PubMedCrossRefGoogle Scholar
  7. Bell A, Land N, Milne S, Hassanyeh F (1994) Long-term outcome of post-partum psychiatric illness requiring admission. J Affect Disord 31:67–70PubMedCrossRefGoogle Scholar
  8. Bellivier F, Szoke A, Henry C, Lacoste J, Bottos C, Nosten-Bertrand M, Hardy P, Rouillon F, Launay JM, Laplanche JL, Leboyer M (2000) Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biol Psychiatry 48(4):319–322PubMedCrossRefGoogle Scholar
  9. Bethea CL, Lu NZ, Gundlah C, Streicher JM (2002) Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol 23(1):41–100. doi:10.1006/frne.2001.0225 PubMedCrossRefGoogle Scholar
  10. Beyer C, Pawlak J, Karolczak M (2003) Membrane receptors for oestrogen in the brain. J Neurochem 87:545–550PubMedCrossRefGoogle Scholar
  11. Binder EB, Jeffrey Newport D, Zach EB, Smith AK, Deveau TC, Altshuler LL, Cohen LS, Stowe ZN, Cubells JF (2010) A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort. J Psychiatr Res 44(10):640–646. doi:10.1016/j.jpsychires.2009.12.001 PubMedCrossRefGoogle Scholar
  12. Bloch M, Schmidt P, Danaceau M, Murphy J, Nieman L, Rubinow D (2000) Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 157:924–930PubMedCrossRefGoogle Scholar
  13. Caspi A, Sugden K, Moffitt T, Taylor A, Craig I, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003a) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389PubMedCrossRefGoogle Scholar
  14. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003b) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301(5631):386–389PubMedCrossRefGoogle Scholar
  15. Cervilla JA, Rivera M, Molina E, Torres-Gonzalez F, Bellon JA, Moreno B, de Dios LJ, Lorente JA, de Diego-Otero Y, King M, Nazareth I, Gutierrez B (2006) The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: the PREDICT-gene study. Am J Med Genet B Neuropsychiatr Genet 141B(8):912–917PubMedCrossRefGoogle Scholar
  16. Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH (2013) Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493(7433):532–536. doi:10.1038/nature11713 PubMedCrossRefGoogle Scholar
  17. Comings D, Muhleman D, Johnson P, MacMurray J (1999) Potential role of the estrogen receptor gene (ESR1) in anxiety. Mol Psychiatr 4(4):374–377CrossRefGoogle Scholar
  18. Costas J, Gratacos M, Escaramis G, Martin-Santos R, de Diego Y, Baca-Garcia E, Canellas F, Estivill X, Guillamat R, Guitart M, Gutierrez-Zotes A, Garcia-Esteve L, Mayoral F, Molto MD, Phillips C, Roca M, Carracedo A, Vilella E, Sanjuan J (2010) Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women. J Psychiatr Res 44(11):717–724. doi:10.1016/j.jpsychires.2009.12.012 PubMedCrossRefGoogle Scholar
  19. Cox J, Holden J, Sagovsky R (1987) Detection of postnatal depression: Development of the 10-item Edinburgh Postnatal depression scale. Br J Psychiatry 150:782–786PubMedCrossRefGoogle Scholar
  20. Deecher D, Andree TH, Sloan D, Schechter LE (2008) From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes. Psychoneuroendocrinology 33(1):3–17PubMedCrossRefGoogle Scholar
  21. Domschke K, Dannlowski U, Ohrmann P, Lawford B, Bauer J, Kugel H, Heindel W, Young R, Morris P, Arolt V, Deckert J, Suslow T, Baune BT (2008) Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. Eur Neuropsychopharmacol 18(10):751–759PubMedCrossRefGoogle Scholar
  22. Doornbos B, Dijck-Brouwer DA, Kema IP, Tanke MA, van Goor SA, Muskiet FA, Korf J (2009) The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. Prog Neuropsychopharmacol Biol Psychiatry 33(7):1250–1254. doi:10.1016/j.pnpbp.2009.07.013 PubMedCrossRefGoogle Scholar
  23. Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF (2006) Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology (Berlin) 186(3):425–433CrossRefGoogle Scholar
  24. Figueira P, Malloy-Diniz L, Campos SB, Miranda DM, Romano-Silva MA, De Marco L, Neves FS, Correa H (2010) An association study between the Val66Met polymorphism of the BDNF gene and postpartum depression. Arch Womens Ment Health 13(3):285–289. doi:10.1007/s00737-010-0146-6 PubMedCrossRefGoogle Scholar
  25. Fink G, Sumner BE, McQueen JK, Wilson H, Rosie R (1998) Sex steroid control of mood, mental state and memory. Clin Exp Pharmacol Physiol 25(10):764–775PubMedCrossRefGoogle Scholar
  26. Forty L, Jones L, Macgregor S, Caesar S, Cooper C, Hough A, Dean L, Dave S, Farmer A, McGuffin P, Brewster S, Craddock N, Jones I (2006) Familiality of postpartum depression in unipolar disorder: results of a family study. Am J Psychiatry 163(9):1549–1553PubMedCrossRefGoogle Scholar
  27. Gade-Andavolu R, Macmurray J, Comings DE, Calati R, Chiesa A, Serretti A (2009) Association between the estrogen receptor TA polymorphism and Harm avoidance. Neurosci Lett 467(2):155–158. doi:10.1016/j.neulet.2009.10.028 PubMedCrossRefGoogle Scholar
  28. Halbreich U, Rojansky N, Palter S, Tworek H, Hissin P, Wang K (1995) Estrogen augments serotonergic activity in postmenopausal women. Biol Psychiatry 37(7):434–441. doi:10.1016/0006-3223(94)00181-2 PubMedCrossRefGoogle Scholar
  29. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66(6):2621–2624PubMedCrossRefGoogle Scholar
  30. Kugaya A, Epperson CN, Zoghbi S, van Dyck CH, Hou Y, Fujita M, Staley JK, Garg PK, Seibyl JP, Innis RB (2003) Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women. Am J Psychiatry 160(8):1522–1524PubMedCrossRefGoogle Scholar
  31. Kunnas TA, Holmberg-Marttila D, Karhunen PJ (1999) Analysis of estrogen receptor dinucleotide polymorphism by capillary gel electrophoresis with a population genetic study in 180 Finns. Hum Hered 49(3):142–145PubMedCrossRefGoogle Scholar
  32. Lazinski M, Shea A, Steiner M (2008) Effects of maternal stress on offspring development. Arch Womens Ment Health 11:363–375PubMedCrossRefGoogle Scholar
  33. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274(5292):1527–1531PubMedCrossRefGoogle Scholar
  34. Lim J, Papp A, Pinsonneault J, Sadee W, Saffen D (2006) Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR. Mol Psychiatry 11:649–662PubMedCrossRefGoogle Scholar
  35. Lim J, Pinsonneault J, Sadee W, Saffen D (2007) Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Mol Psychiatry 12(5):491–501PubMedGoogle Scholar
  36. Lokuge S, Frey B, Foster J, Soares C, Steiner M (2011a) Neurobiological basis of depression in women: new insights into the link between estrogen and serotonin. J Clin Psychiatry 72:e1563–e1569PubMedCrossRefGoogle Scholar
  37. Lokuge S, Frey BN, Foster JA, Soares CN, Steiner M (2010) The rapid effects of estrogen: a mini-review. Behav Pharmacol 21(5–6):465–472. doi:10.1097/FBP.0b013e32833da5c3 PubMedCrossRefGoogle Scholar
  38. Lokuge S, Frey BN, Foster JA, Soares CN, Steiner M (2011b) Depression in women: windows of vulnerability and new insights into the link between estrogen and serotonin. J Clin Psychiatry 72(11):e1563–1569. doi:10.4088/JCP.11com07089 Google Scholar
  39. Mahon PB, Payne JL, MacKinnon DF, Mondimore FM, Goes FS, Schweizer B, Jancic D, Coryell WH, Holmans PA, Shi J, Knowles JA, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Zandi PP, Potash JB (2009) Genome-wide linkage and follow-up association study of postpartum mood symptoms. Am J Psychiatry 166(11):1229–1237. doi:10.1176/appi.ajp.2009.09030417 PubMedCrossRefGoogle Scholar
  40. McEwen B (2001) Estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol 91:2785–2801PubMedGoogle Scholar
  41. McQueen JK, Wilson H, Fink G (1997) Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain Res Mol Brain Res 45(1):13–23PubMedCrossRefGoogle Scholar
  42. McQueen JK, Wilson H, Sumner BE, Fink G (1999) Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids. Brain Res Mol Brain Res 63(2):241–247PubMedCrossRefGoogle Scholar
  43. Mehta D, Quast C, Fasching PA, Seifert A, Voigt F, Beckmann MW, Faschingbauer F, Burger P, Ekici AB, Kornhuber J, Binder EB, Goecke TW (2012) The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptoms. J Affect Disord 136(3):1192–1197. doi:10.1016/j.jad.2011.11.042 PubMedCrossRefGoogle Scholar
  44. Michopoulos V, Berga SL, Wilson ME (2011) Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. Exp Clin Psychopharmacol 19(6):401–408. doi:10.1037/a0025008 2011-17877-001 PubMedCrossRefGoogle Scholar
  45. Mill J, Kiss E, Baji I, Kapornai K, Daróczy G, Vetró A, Kennedy J, Kovacs M, Barr C (2008) Association study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet 147B:1323–1326PubMedCrossRefGoogle Scholar
  46. Miller S, Dykes D, Polesky H (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215PubMedCrossRefGoogle Scholar
  47. Montgomery S, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389PubMedCrossRefGoogle Scholar
  48. Mrazek DA, Rush AJ, Biernacka JM, O’Kane DJ, Cunningham JM, Wieben ED, Schaid DJ, Drews MS, Courson VL, Snyder KA, Black JL, 3rd, Weinshilboum RM (2008) SLC6A4 variation and citalopram response. Am J Med Genet B Neuropsychiatr GenetGoogle Scholar
  49. Murphy-Eberenz K, Zandi PP, March D, Crowe RR, Scheftner WA, Alexander M, McInnis MG, Coryell W, Adams P, DePaulo JR Jr, Miller EB, Marta DH, Potash JB, Payne J, Levinson DF (2006) Is perinatal depression familial? J Affect Disord 90(1):49–55PubMedCrossRefGoogle Scholar
  50. Murphy GM Jr, Hollander SB, Rodrigues HE, Kremer C, Schatzberg AF (2004) Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Arch Gen Psychiatry 61(11):1163–1169PubMedCrossRefGoogle Scholar
  51. Nott P, Franklin M, Armitage C, Gelder M (1976) Hormonal changes and mood in the puerperium. Br J Psychiatry 128:379–383PubMedCrossRefGoogle Scholar
  52. Payne JL, Roy PS, Murphy-Eberenz K, Weismann MM, Swartz KL, McInnis MG, Nwulia E, Mondimore FM, MacKinnon DF, Miller EB, Nurnberger JI, Levinson DF, DePaulo JR Jr, Potash JB (2007) Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder. J Affect Disord 99(1–3):221–229PubMedCrossRefGoogle Scholar
  53. Pecins-Thompson M, Brown NA, Bethea CL (1998) Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques. Brain Res Mol Brain Res 53(1–2):120–129PubMedCrossRefGoogle Scholar
  54. Peter I, Kelley-Hedgepeth A, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GF (2009) Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens 23(10):636–644. doi:10.1038/jhh.2009.1 jhh20091 PubMedCrossRefGoogle Scholar
  55. Pinsonneault J, Papp A, Sadee W (2006) Allelic expression of monoamine oxidase A (MAOA) in human brain: Evidence for cis-acting genetic and epigenetic factors. Hum Mol Gen 15(17):2636–2649PubMedCrossRefGoogle Scholar
  56. Pinsonneault JK, Han DD, Burdick KE, Kataki M, Bertolino A, Malhotra AK, Gu HH, Sadee W (2011) Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology 36(8):1644–1655. doi:10.1038/npp.2011.45 npp201145 PubMedCrossRefGoogle Scholar
  57. Ryan J, Scali J, Carriere I, Peres K, Rouaud O, Scarabin PY, Ritchie K, Ancelin ML (2011) Oestrogen receptor polymorphisms and late-life depression. Br J Psychiatry 199(2):126–131. doi:10.1192/bjp.bp.111.091751 PubMedCrossRefGoogle Scholar
  58. Ryan J, Scali J, Carriere I, Peres K, Rouaud O, Scarabin PY, Ritchie K, Ancelin ML (2012) Estrogen receptor alpha gene variants and major depressive episodes. J Affect Disord 136(3):1222–1226. doi:10.1016/j.jad.2011.10.010 PubMedCrossRefGoogle Scholar
  59. Sanjuan J, Martin-Santos R, Garcia-Esteve L, Carot JM, Guillamat R, Gutierrez-Zotes A, Gornemann I, Canellas F, Baca-Garcia E, Jover M, Navines R, Valles V, Vilella E, de Diego Y, Castro JA, Ivorra JL, Gelabert E, Guitart M, Labad A, Mayoral F, Roca M, Gratacos M, Costas J, van Os J, de Frutos R (2008) Mood changes after delivery: role of the serotonin transporter gene. Br J Psychiatry 193(5):383–388. doi:10.1192/bjp.bp.107.045427 PubMedCrossRefGoogle Scholar
  60. Sano M, Inoue S, Hosoi T, Ouchi Y, Emi M, Shiraki M, Orimo H (1995) Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis. Biochem Biophys Res Commun 217(1):378–383. doi:10.1006/bbrc.1995.2787 PubMedCrossRefGoogle Scholar
  61. Scheid JM, Holzman CB, Jones N, Friderici KH, Nummy KA, Symonds LL, Sikorskii A, Regier MK, Fisher R (2007) Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype. Genes Brain Behav 6(5):453–464. doi:10.1111/j.1601-183X.2006.00272 PubMedCrossRefGoogle Scholar
  62. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33, quiz 34–57PubMedGoogle Scholar
  63. Smith RM, Papp AC, Webb A, Ruble CL, Munsie LM, Nisenbaum LK, Kleinman JE, Lipska BK, Sadee W (2012) Multiple Regulatory Variants Modulate Expression of 5-Hydroxytryptamine 2A Receptors in Human Cortex. Biol Psychiatry. doi:S0006-3223(12)00854-2 [pii] 10.1016/j.biopsych.2012.09.028Google Scholar
  64. Spitzer RL, Williams JB, Gibbon M, First MB (1992) The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Arch Gen Psychiatry 49(8):624–629PubMedCrossRefGoogle Scholar
  65. Stahl S (2001) Effects of estrogen on the central nervous system. J Clin Psychiatry 62:317–318PubMedCrossRefGoogle Scholar
  66. Steiner M (1998) Perinatal mood disorders: position paper. Psychopharmacol Bull 34:301–306PubMedGoogle Scholar
  67. Steiner M, Dunn E, Born L (2003) Hormones and mood: from menarche to menopause and beyond. J Affect Disord 74(1):67–83PubMedCrossRefGoogle Scholar
  68. Sun HS, Tsai HW, Ko HC, Chang FM, Yeh TL (2004) Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Genes Brain Behav 3(6):328–336PubMedCrossRefGoogle Scholar
  69. Treloar SA, Martin NG, Bucholz KK, Madden PA, Heath AC (1999) Genetic influences on post-natal depressive symptoms: findings from an Australian twin sample. Psychol Med 29(3):645–654PubMedCrossRefGoogle Scholar
  70. Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K (2013) Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493(7433):537–541. doi:10.1038/nature11740 nature11740 PubMedCrossRefGoogle Scholar
  71. Xie L, Innis SM (2009) Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study. J Nutrigenet Nutrigenomics 2(4–5):243–250. doi:10.1159/000255636 PubMedCrossRefGoogle Scholar
  72. Yu YW, Tsai SJ, Chen TJ, Lin CH, Hong CJ (2002) Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Mol Psychiatry 7(10):1115–1119PubMedCrossRefGoogle Scholar
  73. Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee M, Xiao T, Papp A, Wang D, Sadée W (2007) Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci U S A 104(51):20552–20557PubMedCrossRefGoogle Scholar
  74. Zill P, Engel R, Baghai TC, Juckel G, Frodl T, Muller-Siecheneder F, Zwanzger P, Schule C, Minov C, Behrens S, Rupprecht R, Hegerl U, Moller HJ, Bondy B (2002) Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. Neuropsychopharmacology 26(4):489–493PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Julia K. Pinsonneault
    • 1
  • Danielle Sullivan
    • 1
    • 2
  • Wolfgang Sadee
    • 1
  • Claudio N. Soares
    • 3
  • Elizabeth Hampson
    • 4
  • Meir Steiner
    • 3
  1. 1.Department of Pharmacology and Program in PharmacogenomicsThe Ohio State University College of MedicineColumbusUSA
  2. 2.The Department of Biostatistics, College of Public HealthThe Ohio State UniversityColumbusUSA
  3. 3.Women’s Health Concerns Clinic, St. Joseph’s Healthcare, Department of Psychiatry & Behavioral Neurosciences and Obstetrics & GynecologyMcMaster UniversityHamiltonCanada
  4. 4.Department of Psychology and Graduate Program in NeuroscienceUniversity of Western OntarioLondonCanada

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