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The efficacy of classical massage on stress perception and cortisol following primary treatment of breast cancer

Abstract

To investigate the efficacy of classical massage on stress perception and mood disturbances, 34 women diagnosed with primary breast cancer were randomized into an intervention or control group. For a period of 5 weeks, the intervention group (n = 17) received biweekly 30-min classical massages. The control group (n = 17) received no additional treatment to their routine health care. The Perceived Stress Questionnaire (PSQ) and the Berlin Mood Questionnaire (BSF) were used and the patients’ blood was collected at baseline (T1), at the end of the intervention period (T2), and 6 weeks after T2 (T3). Compared with control group, women in the intervention group reported significantly lower mood disturbances, especially for anger (p = 0.048), anxious depression (p = 0.03) at T2, and tiredness at T3 (p = 0.01). No group differences were found in PSQ scales, cortisol and serotonin concentrations at T2 and T3. However, perceived stress and cortisol serum levels (p = 0.03) were significantly reduced after massage therapy (T2) compared with baseline in the intervention group. Further research is needed to validate our findings.

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References

  • Ahles TA, Tope DM, Pinkson B, Walch S, Hann D, Whedon M, Dain B, Weiss JE, Mills L, Silberfarb PM (1999) Massage therapy for patients undergoing autologous bone marrow transplantation. J Pain Symptom Manage 18:157–163

    Article  CAS  PubMed  Google Scholar 

  • Alder J, Bitzer J (2003) Retrospective evaluation of the treatment for breast cancer: how does the patient’s personal experience of the treatment affect later adjustment to the illness? Arch Womens Ment Health 6:91–97

    Article  CAS  PubMed  Google Scholar 

  • Bost N, Wallis M (2006) The effectiveness of a 15 minute weekly massage in reducing physical and psychological stress in nurses. Aust J Adv Nurs 23:28–33

    PubMed  Google Scholar 

  • Burgess C, Cornelius V, Love S, Graham J, Richards M, Ramirez A (2005) Depression and anxiety in women with early breast cancer: five year observational cohort study. BMJ 330:702

    Article  PubMed  Google Scholar 

  • Cambron JA, Dexheimer J, Coe P, Swenson R (2007) Side-effects of massage therapy: a cross-sectional study of 100 clients. J Altern Complement Med 13:793–796

    Article  PubMed  Google Scholar 

  • Chida Y, Steptoe A (2009) Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol 80:265–278

    Article  PubMed  Google Scholar 

  • Corbin L (2005) Safety and efficacy of massage therapy for patients with cancer. Cancer Control 12:158–164

    PubMed  Google Scholar 

  • Corner J, Cawley N, Hildebrand S (1995) An evaluation of the use of massage and essential oils on the wellbeing of cancer patients. Int J Palliat Nurs 1:67–73

    Google Scholar 

  • Diego MA, Field T, Sanders C, Hernandez-Reif M (2004) Massage therapy of moderate and light pressure and vibrator effects on EEG and heart rate. Int J Neurosci 114:31–44

    Article  PubMed  Google Scholar 

  • Diego MA, Field T, Hernandez-Reif M (2005) Vagal activity, gastric motility, and weight gain in massaged preterm neonates. J Pediatr 147:50–55

    Article  PubMed  Google Scholar 

  • Ernst E (2003) The safety of massage therapy. Rheumatology (Oxford) 42:1101–1106

    Article  CAS  Google Scholar 

  • Field T, Henteleff T, Hernandez-Reif M, Martinez E, Mavunda K, Kuhn C, Schanberg S (1998) Children with asthma have improved pulmonary functions after massage therapy. J Pediatr 132:854–858

    Article  CAS  PubMed  Google Scholar 

  • Field T, Diego MA, Hernandez-Reif M, Schanberg S, Kuhn C (2004) Massage therapy effects on depressed pregnant women. J Psychosom Obstet Gynaecol 25:115–122

    Article  CAS  PubMed  Google Scholar 

  • Fliege H, Rose M, Arck P, Walter OB, Kocalevent RD, Weber C, Klapp BF (2005) The Perceived Stress Questionnaire (PSQ) reconsidered: validation and reference values from different clinical and healthy adult samples. Psychosom Med 67:78–88

    Article  PubMed  Google Scholar 

  • Fobair P, Stewart SL, Chang S, D'Onofrio C, Banks PJ, Bloom JR (2006) Body image and sexual problems in young women with breast cancer. Psychooncology 15:579–594

    Article  PubMed  Google Scholar 

  • Gold PW, Chrousos GP (2002) Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry 7:254–275

    Article  CAS  PubMed  Google Scholar 

  • Grealish L, Lomasney A, Whiteman B (2000) Foot massage. A nursing intervention to modify the distressing symptoms of pain and nausea in patients hospitalized with cancer. Cancer Nurs 23:237–243

    Article  CAS  PubMed  Google Scholar 

  • Hart S, Field T, Hernandez-Reif M, Nearing G, Shaw S, Schanberg S, Kuhn C (2001) Anorexia nervosa symptoms are reduced by massage therapy. Eat Disord 9:289–299

    Article  CAS  PubMed  Google Scholar 

  • Hecheltjen K-G, Mertesdorf F (1973) Entwicklung eines mehrdimensionalen Stimmungsfragebogen. Gruppendynamik 40:110–122

    Google Scholar 

  • Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U (2003) Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54:1389–1398

    Article  CAS  PubMed  Google Scholar 

  • Hernandez-Reif M, Ironson G, Field T, Hurley J, Katz G, Diego M, Weiss S, Fletcher MA, Schanberg S, Kuhn C, Burman I (2004) Breast cancer patients have improved immune and neuroendocrine functions following massage therapy. J Psychosom Res 57:45–52

    Article  PubMed  Google Scholar 

  • Hernandez-Reif M, Field T, Ironson G, Beutler J, Vera Y, Hurley J, Fletcher MA, Schanberg S, Kuhn C, Fraser M (2005) Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy. Int J Neurosci 115:495–510

    Article  PubMed  Google Scholar 

  • Hörhold M, Klapp BF (1993) Testing the invariance and hierarchy of a multidimensional model of mood by means of repeated measurement with student and patient sample. Z Med Psychol 1:27–35

    Google Scholar 

  • Ironson G, Field T, Scafidi F, Hashimoto M, Kumar M, Kumar A, Price A, Goncalves A, Burman I, Tetenman C, Patarca R, Fletcher MA (1996) Massage therapy is associated with enhancement of the immune system’s cytotoxic capacity. Int J Neurosci 84:205–217

    Article  CAS  PubMed  Google Scholar 

  • Leonard BE (2005) The HPA and immune axes in stress: the involvement of the serotonergic system. Eur Psychiatry 20(Suppl 3):S302–S306

    Article  PubMed  Google Scholar 

  • Levenstein S, Prantera C, Varvo V, Scribano ML, Berto E, Luzi C, Andreoli A (1993) Development of the Perceived Stress Questionnaire: a new tool for psychosomatic research. J Psychosom Res 37:19–32

    Article  CAS  PubMed  Google Scholar 

  • Listing M, Voigt B, Neumann M, Klapp BF, Rauchfuss M (2007) Massage for breast cancer patients. Geburtshilfe Frauenheilkd 67:182

    Article  Google Scholar 

  • Listing M, Reisshauer A, Krohn M, Voigt B, Tjahono G, Becker J, Klapp BF, Rauchfuss M (2009) Massage therapy reduces physical discomfort and improves mood disturbances in women with breast cancer. Psychooncology 18(12):1290–1299

    Article  PubMed  Google Scholar 

  • Lorr M, McNair DM, Fisher SU (1982) Evidence for bipolar mood states. J Pers Assess 46:432–436

    Article  CAS  PubMed  Google Scholar 

  • Mehnert A, Koch U (2007) Prevalence of acute and post-traumatic stress disorder and comorbid mental disorders in breast cancer patients during primary cancer care: a prospective study. Psychooncology 16:181–188

    Article  PubMed  Google Scholar 

  • Moyer CA, Rounds J, Hannum JW (2004) A meta-analysis of massage therapy research. Psychol Bull 130:3–18

    Article  PubMed  Google Scholar 

  • Nowlis V (1965) Research with the mood adjective list. In: Tomkins SS, Jzard CE (eds) Affect, Cognition and Personality. Springer, New York

    Google Scholar 

  • Ouchi Y, Kanno T, Okada H, Yoshikawa E, Shinke T, Nagasawa S, Minoda K, Doi H (2006) Changes in cerebral blood flow under the prone condition with and without massage. Neurosci Lett 407:131–135

    Article  CAS  PubMed  Google Scholar 

  • Palesh OG, Collie K, Batiuchok D, Tilston J, Koopman C, Perlis ML, Butler LD, Carlson R, Spiegel D (2007) A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer. Biol Psychol 75:37–44

    Article  PubMed  Google Scholar 

  • Pariante CM, Miller AH (2001) Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49:391–404

    Article  CAS  PubMed  Google Scholar 

  • Post-White J, Kinney ME, Savik K, Gau JB, Wilcox C, Lerner I (2003) Therapeutic massage and healing touch improve symptoms in cancer. Integr Cancer Ther 2:332–344

    Article  PubMed  Google Scholar 

  • Reiche EM, Nunes SO, Morimoto HK (2004) Stress, depression, the immune system, and cancer. Lancet Oncol 5:617–625

    Article  CAS  PubMed  Google Scholar 

  • Rose M, Burkert U, Scholler G, Schirop T, Danzer G, Klapp BF (1998) Determinants of the quality of life of patients with diabetes under intensified insulin therapy. Diabetes Care 21:1876–1885

    Article  CAS  PubMed  Google Scholar 

  • Sehlen S, Hollenhorst H, Schymura B, Herschbach P, Aydemir U, Firsching M, Duhmke E (2003) Psychosocial stress in cancer patients during and after radiotherapy. Strahlenther Onkol 179:175–180

    Article  PubMed  Google Scholar 

  • Smith MC, Kemp J, Hemphill L, Vojir CP (2002) Outcomes of therapeutic massage for hospitalized cancer patients. J Nurs Scholarsh 34:257–262

    Article  PubMed  Google Scholar 

  • Soden K, Vincent K, Craske S, Lucas C, Ashley S (2004) A randomized controlled trial of aromatherapy massage in a hospice setting. Palliat Med 18:87–92

    Article  PubMed  Google Scholar 

  • Song RH, Kim DH (2006) The effects of foot reflexion massage on sleep disturbance, depression disorder, and the physiological index of the elderly. Taehan Kanho Hakhoe Chi 36:15–24

    PubMed  Google Scholar 

  • Stringer J, Swindell R, Dennis M (2008) Massage in patients undergoing intensive chemotherapy reduces serum cortisol and prolactin. Psychooncology 17(10):1024–1031

    Article  PubMed  Google Scholar 

  • Swaab DF, Bao AM, Lucassen PJ (2005) The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 4:141–194

    Article  CAS  PubMed  Google Scholar 

  • Taylor AG, Galper DI, Taylor P, Rice LW, Andersen W, Irvin W, Wang XQ, Harrell FE Jr (2003) Effects of adjunctive Swedish massage and vibration therapy on short-term postoperative outcomes: a randomized, controlled trial. J Altern Complement Med 9:77–89

    Article  PubMed  Google Scholar 

  • Uvnas-Moberg K, Petersson M (2005) Oxytocin, a mediator of anti-stress, well-being, social interaction, growth and healing. Z Psychosom Med Psychother 51:57–80

    PubMed  Google Scholar 

  • Wikstrom S, Gunnarsson T, Nordin C (2003) Tactile stimulus and neurohormonal response: a pilot study. Int J Neurosci 113:787–793

    Article  CAS  PubMed  Google Scholar 

  • Yau JL, Hibberd C, Noble J, Seckl JR (2002) The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats. Brain Res Mol Brain Res 106:117–123

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Miriam Listing.

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Listing, M., Krohn, M., Liezmann, C. et al. The efficacy of classical massage on stress perception and cortisol following primary treatment of breast cancer. Arch Womens Ment Health 13, 165–173 (2010). https://doi.org/10.1007/s00737-009-0143-9

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  • DOI: https://doi.org/10.1007/s00737-009-0143-9

Keywords

  • Breast cancer
  • Cortisol
  • Serotonin
  • Mood disturbances