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Differences in degree of trapping between AR-R15896 and other uncompetitive NMDA receptor antagonists

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NMDA antagonists like AR-R15896 have been selected on the basis of their good therapeutic indices. As Dr. Rogawski has pointed out, there may be a number of molecular factors which can improve the therapeutic index of NMDA antagonists. In this paper we will consider three factors; use-dependence, low affinity/fast kinetics, and partial trapping.

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Received August 31, 1999 Accepted September 3, 1999

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Lanthorn, T., Mealing, G. & Morley, P. Differences in degree of trapping between AR-R15896 and other uncompetitive NMDA receptor antagonists. Amino Acids 19, 173–175 (2000). https://doi.org/10.1007/s007260070046

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  • DOI: https://doi.org/10.1007/s007260070046

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