Amino Acids

, Volume 50, Issue 3–4, pp 383–395 | Cite as

Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine

  • Olga Golubnitschaja
  • Nora Filep
  • Kristina Yeghiazaryan
  • Henricus Johannes Blom
  • Martin Hofmann-Apitius
  • Walther Kuhn
Original Article


Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a particularly aggressive type of breast cancer lacking clear diagnostic approach and targeted therapies. Consequently, more than 50% of the TNBC patients die of the metastatic BC within the first 6 months of the diagnosis. In the current study we have hypothesised that multi-omic approach utilising blood samples may lead to discovery of a unique molecular signature of the TNBC subtype. The results achieved demonstrate, indeed, multi-omics as highly promising approach that could be of great clinical utility for development of predictive diagnosis, targeted prevention and treatments tailored to the person—overall advancing the management of the TNBC.


Breast cancer Triple-negative breast cancer Menopause *Omics Predictive diagnosis Biomarker pattern 



The authors thank Dr. M. Fountoulakis for his great contribution to the proteomic part of the project. Further, authors thank Ms. G. Windisch-Schuster for performing the “Western-blot” analysis.

Compliance with ethical standards


The study funding has been performed by the Breast Cancer Research Centre, University of Bonn, Bonn, Germany. KY has been awarded with corresponding fellowship by the European Association for Predictive, Preventive and Personalised Medicine (EPMA, Belgium).

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

All the patient investigations conformed to the principles outlined in the Declaration of Helsinki and have been performed with the permission (Nr. 148/05) released by the responsible Ethic’s Committee of the Medical Faculty, Rheinische Friedrich-Wilhelms- University of Bonn. Human rights’ have been obligatory protected during the entire duration of the project according to the European standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of RadiologyRheinische Friedrich-Wilhelms-Universität BonnBonnGermany
  2. 2.Breast Cancer Research CentreRheinische Friedrich-Wilhelms-Universität BonnBonnGermany
  3. 3.Centre for Integrated OncologyCologne-Bonn, Rheinische Friedrich-Wilhelms-Universität BonnBonnGermany
  4. 4.Department of BioinformaticsFraunhofer Institute for Algorithms and Scientific Computing (SCAI)Sankt AugustinGermany
  5. 5.Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and NeonatologyUniversity Medical Centre FreiburgFreiburgGermany
  6. 6.Centre for Obstetrics and GynaecologyRheinische Friedrich-Wilhelms-Universität BonnBonnGermany

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